Lifeboat Foundation

BioAge Labs, a clinical-stage biotech developing therapeutics that target the molecular causes of aging to extend healthy human lifespan, today announced positive Phase 1b clinical data for BGE-105, a highly selective, potent, orally available small-molecule agonist of the apelin receptor APJ.

BGE-105 treatment resulted in statistically significant prevention of muscle atrophy relative to placebo in healthy volunteers aged 65 or older after 10 days of strict bed rest.

Longevity. Technology: Muscle atrophy – loss of muscle mass and strength – is a universal feature of human aging that increases the risk of multiple morbidities, shortens lifespan and diminishes quality of life. Hospitalisation and periods of forced inactivity greatly accelerate this loss in older people.

Spermidine is a popular longevity supplement – and with good reason, as it has antiaging properties and can suppress inflammation and oxidation. Studies have shown the interestingly-named polyamine can increase lifespan in animal models, and research indicates that its decline with aging is linked to the onset of age-related diseases.

Longevity. Technology: All this background is useful if you are wondering if supplements are right for you and if so, which ones to take. However, having a professional perspective is always useful, and founder of Impact Health Dr Halland Chen MD is a Double Board-Certified doctor who is a Partnered Practitioner of spermidineLIFE. We caught up with Dr Chen to find out what it is like practising at the cutting edge of longevity medicine, and what are some of the most promising interventions he recommends to his patients.

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Growing miniature organ-like tissues in the lab is already within our reach. Now, researchers from Japan have developed a new approach that enables intestinal mini-organs to be grown more easily and efficiently in the lab. This holds immense promise for regenerative medicine.

In a study published in November in Cell Reports Methods, researchers from Tokyo Medical and Dental University (TMDU) reveal that applying a few specialized lab techniques yields intestine-like tissues of predictable size and composition.

Organoids are organ-like balls of cells that are grown in the lab from spheroids (even smaller balls) of human cells and mimic the properties of the organ from which the “seed” cell was taken. Organoids are used for studying organ function in a lab setting and are also promising tools in the field of regenerative medicine.

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The artificial intelligence tool, known as FRAN, can make someone look a different age in five seconds.

Researchers at Disney have built an artificial intelligence tool that can make it easier for an actor to appear a different age on screen. Although digital artists can still make necessary modifications to make the effects in a scene look as realistic as possible, the artificial intelligence system can handle most of the aging effects.

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A lot of anti-ageing vids lately. Good. This concerns Turn.bio. Though not in this vid, MH does have a habit of asking ‘When?” at some point. Previously Turn.bio said they have a first working treatment in just a few years so we’ll see what happens in vids to come of this interview.

In this video Professor Sebastiano introduces ERA, Epigenetic Reprogramming of Age technology and talks about his thoughts on some of the causes of aging.

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Patrick Burgermeister of KIZOO Technology Ventures presents at Investing in the Age of Longevity 2022. In his talk, Patrick gives an overview of KIZOO Technology Ventures’ investment strategy, with a particular focus on misson-driven investments in early stage companies that open new categories of treatment. Patrick showcases six biotech startups that form part of the company’s key investments: Cellvie, Revel, Cyclarity, LIfT BioSciences, Elastrin, and Mogling Bio.

Download the presentation slides: https://bit.ly/IAL22-Patrick-Burgermeister.

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Ray Kurzweil is an author, computer scientist, inventor, futurist and a director of engineering at Google. Kurzweil is a public advocate for the futurist and transhumanist movements, and gives public talks to share his optimistic outlook on life extension technologies and the future of nanotechnology, robotics, and biotechnology.

Recorded 2013

Aging inevitably increases the risk of disease, as exemplified by CAD, AD, and cancer. Monitoring the aging process and understanding its mechanisms will not only enhance early diagnoses, it may also provide strategies for the early prevention and treatment of diseases. While biomarkers for cellular senescence in in vitro cultured mammalian cells are already well-defined, those that define in vivo senescence/aging at the systemic level remain scarce. Here, we generated a targeted Glb1^+/m allele at the Glb1 locus that encodes β-galactosidase. The GAC signal indicates Glb1 level. The results reveal that the live-imaged GAC signal is linearly correlated with chronological age, but only in middle-aged mice (9–13 months). High GAC at the MA stage was associated with cardiac hypertrophy and shortened lifespan. Moreover, GAC signal was exponentially increased in pathological lung fibrosis induced by BLM. Thus, this in vivo reporter mouse can faithfully monitor systemic aging and organ functional decline in a manner closely associated with lifespan, and provides an ideal system for studying aging mechanisms and developing anti-aging manipulations.

The upregulation of p16^Ink4a transcription and elevated SAβ-gal staining are both well-established and widely used biomarkers for cellular senescence¹⁷, and the former led to the generation of live-imaging aging reporter mice^20,22,23. Intriguingly, high level of p16^Ink4a, indicated by luciferase activity, predicts cancer initiation rather than lifespan. Similarly, the in vivo application of SAβ-gal as a senescence marker at the tissue level is also limited. Positive SAβ-gal-staining is easy to obtain in kidney and adipose tissue sections but difficult to obtain in blood vessel and heart sections. By SAβ-gal staining, not many positive cells were detected in old individuals²⁶. It raises the question of whether SAβ-gal labels in vivo senescence or if the percentage of in vivo senescent cells is indeed very low.