Loss of epigenetic information can drive aging, restoration can reverse it.
Sources:
Continue reading “How to Reverse Aging? David Sinclair — Epigenetic Information” »
We take a look at and why some researchers think it could be useful in combating aging.
Rapamycin is a macrolide, a class of antibiotic that includes erythromycin, roxithromycin, azithromycin, and clarithromycin. exhibits potent antitumor and immunosuppressive activity.
Where is found?
Aging is characterized by changes in cellular identity and function over time. This process is driven by changes in chromatin factor localization during DNA break repair, which alters the epigenome and advances the epigenetic clock. Expression of a subset of Yamanka factors, OSK, can reverse these changes and modulate aging.
The rebooting came in the form of a gene therapy involving three genes that instruct cells to reprogram themselves—in the case of the mice, the instructions guided the cells to restart the epigenetic changes that defined their identity as, for example, kidney and skin cells, two cell types that are prone to the effects of aging. These genes came from the suite of so-called Yamanaka stem cells factors—a set of four genes that Nobel scientist Shinya Yamanaka in 2006 discovered can turn back the clock on adult cells to their embryonic, stem cell state so they can start their development, or differentiation process, all over again. Sinclair didn’t want to completely erase the cells’ epigenetic history, just reboot it enough to reset the epigenetic instructions. Using three of the four factors turned back the clock about 57%, enough to make the mice youthful again.
“We’re not making stem cells, but turning back the clock so they can regain their identity,” says Sinclair. “I’ve been really surprised by how universally it works. We haven’t found a cell type yet that we can’t age forward and backward.”
Rejuvenating cells in mice is one thing, but will the process work in humans? That’s Sinclair’s next step, and his team is already testing the system in non-human primates. The researchers are attaching a biological switch that would allow them to turn the clock on and off by tying the activation of the reprogramming genes to an antibiotic, doxycycline. Giving the animals doxycycline would start reversing the clock, and stopping the drug would halt the process. Sinclair is currently lab-testing the system with human neurons, skin, and fibroblast cells, which contribute to connective tissue.
This might be important. It might not be over for metformin just yet though as a mice study showed that rapamycin combined with metformin removed each other’s side effects.
If you are a non-diabetic who takes metformin for longevity, I highly recommend you stop immediately. Hear me out, and at the end of the video I’ll share what to do instead.
Continue reading “Metformin For Anti-Aging: Disproved & Dangerous!” »
https://www.youtube.com/shorts/0ouF5Tv6y7E
https://www.youtube.com/watch?v=UI-h9mfdiN0
@houseoflongevity Full Longevity Escape Velocity video: https://www.youtube.com/watch?v=UI-h9mfdiN0&t=10s Rich Roll Podcast interview:
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An international study 13 years in the making demonstrates for the first time that degradation in the way DNA is organized and regulated — known as epigenetics — can drive aging in an organism, independently of changes to the genetic code itself.
This is a timeline of transhumanism, attempting to decribe significant events related to the movement. Topics directly related to transhumanism, including extropianism, life extension and eradication of suffering, are also described.
