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Programmable Macrophage Mimics for Inflammatory Meniscus Regeneration via Nanotherapy

JUST PUBLISHED: programmable macrophage mimics for inflammatory meniscus regeneration via nanotherapy

Click here to read the latest free, Open Access Article from Research.

The meniscus is a fibrocartilaginous tissue and organ in the human knee joint that serves critical functions, including load transmission, shock absorption, joint stability, and lubrication. Meniscal injuries are among the most common knee injuries, typically caused by acute trauma or age-related degeneration [1– 3]. Minor meniscal injuries are usually treated with in situ arthroscopic procedures or conservative methods, whereas larger or more severe injuries often necessitate total meniscus replacement. Recent advances in materials science and manufacturing techniques have enabled transformative tissue-engineering strategies for meniscal therapy [4, 5]. Several stem cell types, including synovium-derived mesenchymal stem cells, bone-marrow-derived mesenchymal stem cells, and adipose-derived stem cells (ADSCs), have been investigated as candidate seed cells for meniscal regeneration and repair. Notably, ADSCs are clinically promising because of their ease of harvest, high inducibility, innate anti-inflammatory properties, and potential to promote fibrocartilage regeneration [6– 8]. Our group has developed a series of decellularized matrix scaffolds for auricular, nasal, tracheal, and articular cartilage repair using 3-dimensional (3D) bioprinting techniques, successfully repairing meniscus defects and restoring physiological function [9– 12]. However, current tissue-engineering strategies for meniscus defect repair commonly rely on a favorable regenerative microenvironment. Pathological conditions such as osteoarthritis (OA) [13 – 16], the most prevalent joint disorder, often create inflammatory environments that severely hinder meniscus regeneration [17 – 21]. Moreover, meniscal injury exacerbates the local inflammatory milieu, further impeding tissue healing and inevitably accelerating OA progression. Therefore, there is an urgent need to establish a cartilaginous immune microenvironment that first mitigates early-stage inflammation after meniscal injury and then sequentially promotes later-stage fibrocartilage regeneration [22 – 25].

Currently, targeted regulation using small-molecule drug injections is commonly employed to treat inflammatory conditions in sports medicine [26,27]. Most of these drugs exhibit broad-spectrum anti-inflammatory effects and inevitably cause varying degrees of side effects by activating nonspecific signaling pathways. Polyethyleneimine is a highly cationic polymer. It is widely used to modulate inflammation by adsorbing and removing negatively charged proinflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6), via electrostatic interactions [28–31]. Notably, modifying polyethyleneimine into its branched form (branched polyethyleneimine [BPEI]) has been shown to improve cytocompatibility and enhance in vivo metabolic cycling.

Dr. Marco de Baar, Ph.D. — DIFFER & TU/e — How Plasma Control Will Make Fusion Power Possible

How Plasma Control Will Make Fusion Power Possible — Dr. Marco De Baar Ph.D. — Dutch Institute for Fundamental Energy Research (DIFFER) / TU Eindhoven.

Dr. Marco de Baar, Ph.D. is a full professor and Chair of Plasma Fusion Operation and Control at the Mechanical Engineering Faculty of Eindhoven University of Technology (TU/e — https://www.tue.nl/en/research/resear…

In addition to his work at TU/e, Dr. de Baar is also head of fusion research at the Dutch Institute for Fundamental Energy Research (DIFFER — https://www.differ.nl/) located on the TU/e campus. As member of DIFFER’s management team, he has also served as the Dutch representative in the European fusion research consortium EUROfusion (https://euro-fusion.org/).

From 2004 to 2007, Dr. de Baar headed the operations department at JET (Joint European Torus), Europe’s largest fusion experiment to date, where he was responsible for the successful operation and development of the reactor. From 2007, he was deputy project leader in the international consortium that develops the upper port launcher. He is program-leader for the Magnetohydrodynamics stabilization work package in ITER-NL (International Thermonuclear Experimental Reactor — https://www.iter.org/).

Dr. de Baar’s main scientific interest is the control of nuclear fusion plasmas, with a focus on control of Magnetohydrodynamics modes (for plasma stability) and current density profile (for performance optimization). In his research program, all elements of the control loops are considered, including actuator and sensor design, and advanced control oriented modelling. He also has a keen interest in the operations and the remote maintainability of nuclear fusion reactors.

Continue reading “Dr. Marco de Baar, Ph.D. — DIFFER & TU/e — How Plasma Control Will Make Fusion Power Possible” | >

Modeling human embryo implantation in vitro

The new 3D model system looks to replicate the complex physiological properties and cellular composition of the endometrium. The model is built in a step-by-step process by bringing together the different components of endometrial tissue. The team isolated two essential cell types that form endometrial tissue – epithelial cells and stromal cells – from tissue donated by healthy people who had endometrial biopsies.

As well as the cell types, the researchers sought to recreate the structure of the womb lining. Information from donated endometrial tissue was used to identify the tissue components that give the womb lining its structure. The researchers were able to incorporate these components together with the stromal cells into a special type of gel to support the growth of the cells in a thick layer. On top of this, they added the epithelial cells, which spread out over the surface of the stromal cells.

Once assembled, this formed an advanced replica of the womb lining, matching a biopsy of endometrial tissue in terms of cellular architecture, and showing responses to hormone stimulation that indicate the engineered womb lining’s receptivity for embryo implantation.

The team tested their model using donated early-stage human embryos from IVF procedures, and found that the embryo – at this point a compact ball of cells – underwent the expected stages expected of adhesion and invasion into the endometrial scaffold. Following implantation, the embryos increased secretion of human chorionic gonadotropin (hCG), a biochemical marker used in pregnancy tests to confirm pregnancy, and other pregnancy-associated proteins.

Furthermore, the system supported post-implantation development of the embryo, enabling the analysis of embryo stages (12−14 days post fertilisation) that have been largely unexplored. The researchers observed that implanted embryos reached several developmental milestones, such as the appearance of specialist cell types in the embryo and also the establishment of precursor cell types important for the development of the placenta.

Using single cell analysis of implantation sites, the researchers were able to profile cells at the interface between the embryo and endometrium model, effectively listening in to the molecular communication between the tissues. Their results provide new insight into the complex interactions between the embryo and endometrial environment that underpin embryo development immediately after implantation.

Continue reading “Modeling human embryo implantation in vitro” | >

Quantum calculations expose hidden chemistry of ice

When ultraviolet light hits ice—whether in Earth’s polar regions or on distant planets—it triggers a cascade of chemical reactions that have puzzled scientists for decades.

Now, researchers at the University of Chicago Pritzker School of Molecular Engineering (UChicago PME) and collaborators at the Abdus Salam International Center for Theoretical Physics (ICTP) have used quantum mechanical simulations to reveal how tiny imperfections in ice’s crystal structure dramatically alter how ice absorbs and emits light. The findings, published in Proceedings of the National Academy of Sciences, pave the way for scientists to better understand what happens at a sub-atomic scale when ice melts, which has implications including improving predictions of the release of greenhouse gases from thawing permafrost.

“No one has been able to model what happens when UV light hits ice with this level of accuracy before,” said Giulia Galli, Liew Family Professor of Molecular Engineering and one of the senior authors of the new work. “Our paper provides an important starting point to understand the interaction of light with ice.”

Two-step flash Joule heating method recovers lithium‑ion battery materials quickly and cleanly

A research team at Rice University led by James Tour has developed a two-step flash Joule heating-chlorination and oxidation (FJH-ClO) process that rapidly separates lithium and transition metals from spent lithium-ion batteries. The method provides an acid-free, energy-saving alternative to conventional recycling techniques, a breakthrough that aligns with the surging global demand for batteries used in electric vehicles and portable electronics.

Published in Advanced Materials, this research could transform the recovery of critical battery materials. Traditional recycling methods are often energy intensive, generate wastewater and frequently require harsh chemicals. In contrast, the FJH-ClO process achieves high yields and purity of lithium, cobalt and graphite while reducing energy consumption, chemical usage and costs.

“We designed the FJH-ClO process to challenge the notion that battery recycling must rely on acid leaching,” said Tour, the T.T. and W.F. Chao Professor of Chemistry and professor of materials science and nanoengineering. “FJH-ClO is a fast, precise way to extract valuable materials without damaging them or harming the environment.”

Stem cell engineering breakthrough paves way for next-generation living drugs

For the first time, researchers at UBC have demonstrated how to reliably produce an important type of human immune cell — known as helper T cells — from stem cells in a controlled laboratory setting. The findings, published today in Cell Stem Cell, overcome a major hurdle that has limited the development, affordability and large-scale manufacturing of cell therapies. The discovery could pave the way for more accessible and effective off-the-shelf treatments for a wide range of conditions like cancer, infectious diseases, autoimmune disorders and more.

“This is a major step forward in our ability to develop scalable and affordable immune cell therapies.”

Dr. Peter Zandstra

Ranked among the world’s top medical schools with the fifth-largest MD enrollment in North America, the UBC Faculty of Medicine is a leader in both the science and the practice of medicine. Across British Columbia, more than 12,000 faculty and staff are training the next generation of doctors and health care professionals, making remarkable discoveries, and helping to create the pathways to better health for our communities at home and around the world.

OLED lighting: Corrugated panel design extends longevity and efficiency

The organic light emitting diodes—known widely as OLEDs—that create vibrant smartphone displays could illuminate rooms, but current designs burn out too quickly at the high brightness needed for room lighting. A new approach overcomes this tradeoff by building OLEDs on a corrugated surface, packing more emitting material into a given lighting panel area to produce the same amount of light while operating the OLED itself at lower brightness.

This corrugated panel strategy increased device lifespan by a factor of 2.7 compared to flat panels operated at the same current, according to a study led by the University of Michigan in collaboration with OLEDWorks and The Pennsylvania State University.

“While the problems we solved along the way were daunting, in the end the new device performed tremendously better than predecessors. It’s rewarding to see our ideas point towards a valid path to improve the efficiency and lifetime of OLED lighting,” said Max Shtein, a professor of materials science and engineering and chemical engineering at U-M and co-corresponding author of the study published in Nature Communications.

Entanglement enhances the speed of quantum simulations, transforming long-standing obstacles into a powerful advantage

Researchers from the Faculty of Engineering at The University of Hong Kong (HKU) have made a significant discovery regarding quantum entanglement. This phenomenon, which has long been viewed as a significant obstacle in classical quantum simulations, actually enhances the speed of quantum simulations. The findings are published in Nature Physics in an article titled “Entanglement accelerates quantum simulation.”

Simulating the dynamic evolution of matter is fundamental to understanding the universe, yet it remains one of the most challenging tasks in physics and chemistry. For decades, “entanglement”—the complex correlation between quantum particles—has been viewed as a formidable barrier. In classical computing, high entanglement makes simulations exponentially harder to perform, often acting as a bottleneck for studying complex quantum systems.

Led by Professor Qi Zhao from the School of Computing and Data Science at HKU, the research team collaborated with Professor You Zhou from Fudan University and Professor Andrew M. Childs from the University of Maryland, and overturned this long-held belief. They discovered that while entanglement hinders classical computers, it actually accelerates quantum simulations, turning a former obstacle into a powerful resource.

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