When a gene is turned on in a cell, it creates a ripple effect along the DNA strand, changing the physical structure of the strand. A new study by MIT researchers, appearing in Science, shows that these ripples can stimulate or suppress neighboring genes. These effects, which result from the winding or unwinding of neighboring DNA, are determined by the order of genes along a strand of DNA. Genes upstream of the active gene are usually turned up, while those downstream are inhibited.

The new findings offer guidance that could make it easier to control the output of synthetic gene circuits. By altering the relative ordering and arrangement of genes (gene syntax), researchers could create circuits that synergize to maximize their output, or that alternate the output of two different genes.

“This is really exciting because we can coordinate gene expression in ways that just weren’t possible before,” says Katie Galloway, an assistant professor of chemical engineering at MIT. “Syntax will be really useful for dynamic circuits. Now we have the ability to select not only the biochemistry of circuits, but also the physical design to support dynamics.”

Researchers in the University of Minnesota Twin Cities have discovered a powerful new way to control the electronic behavior of a metal—by manipulating the atomic properties of materials where they meet. The study, published in Nature Communications, demonstrates that interfacial polarization can tune the surface work function of metallic ruthenium dioxide (RuO₂) by more than 1 electron volt (eV)—a tiny amount of energy—simply by adjusting film thickness at the nanometer scale.

“We often think of polarization as something that belongs to insulators or ferroelectrics—not metals,” said Bharat Jalan, professor and Shell Chair in the Department of Chemical Engineering and Materials Science at the University of Minnesota. “Our work shows that, through careful interface design, you can stabilize polarization in a metallic system and use it as a knob to tune electronic properties. This opens an entirely new way of thinking about controlling metals.”

This specific change is most powerful when the metal layer is about 4 nanometers thick—roughly the width of a single strand of DNA. At this precise size, the metal shifts from being “stretched” by the material underneath it to a more “relaxed” state. This transition proves that the physical way atoms are packed together has a direct, measurable impact on how the metal handles electricity.