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Category: engineering

Hair-thin fiber can control thousands of brain neurons simultaneously

Fiber-optic technology revolutionized the telecommunications industry and may soon do the same for brain research.

A group of researchers from Washington University in St. Louis in both the McKelvey School of Engineering and WashU Medicine have created a new kind of fiber-optic device to manipulate neural activity deep in the brain. The device, called PRIME (Panoramically Reconfigurable IlluMinativE) fiber, delivers multi-site, reconfigurable optical stimulation through a single, hair-thin implant.

“By combining fiber-based techniques with optogenetics, we can achieve deep-brain stimulation at unprecedented scale,” said Song Hu, a professor of biomedical engineering at McKelvey Engineering, who collaborated with the laboratory of Adam Kepecs, a professor of neuroscience and of psychiatry at WashU Medicine.

Adapting Next-Generation Sequencing to in Process CRISPR-Cas9 Genome Editing of Recombinant AcMNPV Vectors: From Shotgun to Tiled-Amplicon Sequencing

The alphabaculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is the most commonly used virus in the Baculovirus Expression Vector System (BEVS) and has been utilized for the production of many human and veterinary biologics. AcMNPV has a large dsDNA genome that remains understudied, and relatively unmodified from the wild-type, especially considering how extensively utilized it is as an expression vector. Previously, our group utilized CRISPR-Cas9 genome engineering that revealed phenotypic changes when baculovirus genes are targeted using either co-expressed sgRNA or transfected sgRNA into a stable insect cell line that produced the Cas9 protein.

Protein-based gel restores dental enamel and could advance tooth repair

Scientists from the University of Nottingham’s School of Pharmacy and Department of Chemical and Environmental Engineering, in collaboration with an international team of researchers, have developed a bio-inspired material that has the potential to regenerate demineralized or eroded enamel, strengthen healthy enamel, and prevent future decay. The findings have been published in Nature Communications.

The gel can be rapidly applied to teeth in the same way dentists currently apply standard fluoride treatments. However, this new protein-based gel is fluoride free and works by mimicking key features of the natural proteins that guide the growth of dental enamel in infancy.

When applied, the gel creates a thin and robust layer that impregnates teeth, filling holes and cracks in them. It then functions as a scaffold that takes calcium and phosphate ions from saliva and promotes the controlled growth of new mineral in a process called epitaxial mineralization. This enables the new mineral to be organized and integrated into the underlying natural tissue while recovering both the structure and properties of natural healthy enamel.

Climate intervention may not be enough to save coffee, chocolate and wine

A new study published in Environmental Research Letters reveals that even advanced climate intervention strategies may not be enough to secure the future of wine grapes, coffee and cacao.

These crops are vital to many economies and provide livelihoods for farmers worldwide. However, they are increasingly vulnerable to the effects of . Rising temperatures and changing cause big variations in from year to year, meaning that farmers cannot rely on the stability of their harvest, and their produce is at risk.

The researchers specifically investigated Stratospheric Aerosol Injection (SAI) as a way of mitigating climate change in the top grape, coffee and cacao growing regions of western Europe, South America and West Africa. SAI is a hypothetical solar geoengineering method that involves releasing reflective particles into the stratosphere to cool Earth’s surface, mimicking the natural cooling effects of volcanic eruptions.

“This Is From a Meteorite”: Scientist Stunned by Water Inside 400-Million-Year-Old Plant

The research, led by Zachary Sharp, a professor in UNM’s Department of Earth and Planetary Sciences, was recently published in the Proceedings of the National Academy of Sciences (PNAS). The study centers on horsetails, a family of hollow-stemmed plants that have survived on Earth for more than 400 million years.

The researchers found that water moving through these plants experiences such a powerful natural purification process that its oxygen isotope composition closely matches that of meteorites and other materials from beyond our planet.

“It’s a meter-high cylinder with a million holes in it, equally spaced. It’s an engineering marvel,” Sharp said. “You couldn’t create anything like this in a laboratory.”

Menstrual cup upgrades: Self-cleaning and sustainable design adjustments could make them easier to use

Reusable menstrual cups reduce waste and are more cost-effective than single-use pads and tampons. But some people avoid the cups because they require thorough cleaning and are sometimes messy to empty. To solve these problems, researchers coated a commercially available silicone cup in silicone oil and created a plant-based, absorbent tablet. These design adjustments could make menstrual cups safer and easier to use, according to a study published in ACS Applied Materials & Interfaces.

“This research bridges advanced engineering and women’s health, creating a menstrual product that is not only self-cleaning and sustainable, but also opens doors for future health monitoring,” says Tohid Didar, one of the senior researchers of this study from McMaster University.

Nearly 2 billion people menstruate, and their desire for sustainable, reusable options—menstrual cups, disks and period underwear—is rising. Menstrual cups are designed to hold more fluid than tampons, allowing longer wear than the disposable option, and they can be cleaned and reused for years.

Engineered Immune Cells Improves Anti-Cancer Response

Scientists have developed a way to engineer immune cells that specifically target tumors. The application of engineering cells first appeared in the 1980s, but the concept has significantly progressed over the last few decades. This approach of engineering a patient’s cells as a form of therapy allow the immune system to specifically target the tumor and limit off-target affects.

Chimeric antigen receptor (CAR) T cells is an immunotherapy that takes patient T cells and edits them to target the tumor. The cells are then reinfused to accurately and effectively eliminate tumor growth. Immunotherapy is a general classification of cancer treatments that refers to the redirection of the immune system toward a disease or infection. T cells are responsible for the identification and elimination of infected cells and other diseases. Therefore, they are the optimal cell to engineer for robust and durable antitumor immunity. While scientists are working to engineer other cell types, CAR T cell therapy have been shown to have improved efficacy in multiple types of blood or hematological malignancies.

CAR T cell therapy in solid tumors is less effective. Unfortunately, the environment around the tumor has a complex network of various cell types combined with proteins and other molecules that inhibit CAR T cell efficacy. As a result, these CAR T cells cannot function and contribute to tumor progression. Scientists are currently working to improve CAR T cell therapy and develop stronger anti-cancer treatments.

A new dimension for spin qubits in diamond

The path toward realizing practical quantum technologies begins with understanding the fundamental physics that govern quantum behavior—and how those phenomena can be harnessed in real materials.

In the lab of Ania Jayich, Bruker Endowed Chair in Science and Engineering, Elings Chair in Quantum Science, and co-director of UC Santa Barbara’s National Science Foundation Quantum Foundry, that material of choice is laboratory-grown diamond.

Working at the intersection of materials science and quantum physics, Jayich and her team explore how engineered defects in diamond—known as spin qubits—can be used for quantum sensing. Among the lab’s standout researchers, Lillian Hughes, who recently earned her Ph.D. and will soon begin postdoctoral work at the California Institute of Technology, has achieved a major advance in this effort.

Molecular engineering strategy boosts efficiency of inverted perovskite solar cells

Solar cells, devices that can directly convert radiation emitted from the sun into electricity, have become increasingly widespread and are contributing to the reduction of greenhouse gas emissions worldwide. While existing silicon-based solar cells have attained good performances, energy engineers have been exploring alternative designs that could be more efficient and affordable.

Perovskites, a class of materials with a characteristic crystal structure, have proved to be particularly promising for the development of low-cost and energy-efficient solar energy solutions. Recent studies specifically highlighted the potential of inverted perovskite solar cells, devices in which the extraction charge layers are arranged in the reverse order compared to traditional designs.

Inverted perovskite solar cells could be more stable and easier to manufacture on a large-scale than conventional perovskite-based cells. Nonetheless, most inverted cells developed so far were found to exhibit low energy-efficiencies, due to the uncontrolled formation of crystal grains that can produce defects and adversely impact the transport of charge carriers generated by sunlight.

Lignin increases the stability and effectiveness of herbicide nanoparticles, study shows

A recent study has shown that a fraction obtained from lignin, an organic polymer responsible for the rigidity of plant cell walls, was able to improve the performance of nanoparticles with herbicide.

The work is published in the journal ACS Sustainable Chemistry & Engineering and was recently featured on its cover.

The study was conducted by researchers from three research institutions in the state of São Paulo, Brazil: São Paulo State University (UNESP), the State University of Campinas (UNICAMP), and the Federal University of São Carlos (UFSCar).

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