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Category: engineering

Composite metal foam could lead to safer hazmat transportation

A new study finds that composite metal foam (CMF) can withstand tremendous force—enough to punch a hole in a railroad tank car—at much lower weight than solid steel. The finding raises the possibility of creating a safer generation of tanker cars for transporting hazardous materials.

The researchers have also developed a that can be used to determine what thickness of CMF is needed in order to provide the desired level of protection necessary for any given application. The paper, “Numerical Model and Experimental Validation of Composite Metal Foam in Protecting Carbon Steel Against Puncture,” is published in Advanced Engineering Materials.

“Railroad tank cars are responsible for transporting a wide range of hazardous materials, from acids and chemicals to petroleum and liquefied ,” says Afsaneh Rabiei, corresponding author of a paper on the work and a professor of mechanical and aerospace engineering at North Carolina State University.

Breakthrough could connect quantum computers at 200X the distance

Quantum computers are powerful, lightning-fast and notoriously difficult to connect to one another over long distances.

Previously, the maximum distance two quantum computers could connect through a was a few kilometers. This means that, even if fiber cable were run between them, quantum computers in the University of Chicago’s South Side campus and downtown Chicago’s Willis Tower would be too far apart to communicate with each other.

Research published today in Nature Communications from University of Chicago Pritzker School of Molecular Engineering (UChicago PME) Asst. Prof. Tian Zhong would theoretically extend that maximum to 2,000 km (1,243 miles).

Asymmetric stress engineering advances current-carrying performance of iron-based superconducting wires

A collaborative research team led by Prof. Ma Yanwei from the Institute of Electrical Engineering (IEE) of the Chinese Academy of Sciences (CAS), has shattered records in the current-carrying performance of iron-based superconducting wires.

Their breakthrough, enabled by a novel strategy to engineer high-density flux pinning centers via an asymmetric stress field, is published in Advanced Materials.

The Steady High Magnetic Field Facility (CHMFL), the Hefei Institutes of Physical Science of CAS, played a pivotal role in this achievement, with its water-cooled magnet WM5 providing critical experimental support for validating the wires.

Hair-thin fiber can control thousands of brain neurons simultaneously

Fiber-optic technology revolutionized the telecommunications industry and may soon do the same for brain research.

A group of researchers from Washington University in St. Louis in both the McKelvey School of Engineering and WashU Medicine have created a new kind of fiber-optic device to manipulate neural activity deep in the brain. The device, called PRIME (Panoramically Reconfigurable IlluMinativE) fiber, delivers multi-site, reconfigurable optical stimulation through a single, hair-thin implant.

“By combining fiber-based techniques with optogenetics, we can achieve deep-brain stimulation at unprecedented scale,” said Song Hu, a professor of biomedical engineering at McKelvey Engineering, who collaborated with the laboratory of Adam Kepecs, a professor of neuroscience and of psychiatry at WashU Medicine.

Adapting Next-Generation Sequencing to in Process CRISPR-Cas9 Genome Editing of Recombinant AcMNPV Vectors: From Shotgun to Tiled-Amplicon Sequencing

The alphabaculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is the most commonly used virus in the Baculovirus Expression Vector System (BEVS) and has been utilized for the production of many human and veterinary biologics. AcMNPV has a large dsDNA genome that remains understudied, and relatively unmodified from the wild-type, especially considering how extensively utilized it is as an expression vector. Previously, our group utilized CRISPR-Cas9 genome engineering that revealed phenotypic changes when baculovirus genes are targeted using either co-expressed sgRNA or transfected sgRNA into a stable insect cell line that produced the Cas9 protein.

Protein-based gel restores dental enamel and could advance tooth repair

Scientists from the University of Nottingham’s School of Pharmacy and Department of Chemical and Environmental Engineering, in collaboration with an international team of researchers, have developed a bio-inspired material that has the potential to regenerate demineralized or eroded enamel, strengthen healthy enamel, and prevent future decay. The findings have been published in Nature Communications.

The gel can be rapidly applied to teeth in the same way dentists currently apply standard fluoride treatments. However, this new protein-based gel is fluoride free and works by mimicking key features of the natural proteins that guide the growth of dental enamel in infancy.

When applied, the gel creates a thin and robust layer that impregnates teeth, filling holes and cracks in them. It then functions as a scaffold that takes calcium and phosphate ions from saliva and promotes the controlled growth of new mineral in a process called epitaxial mineralization. This enables the new mineral to be organized and integrated into the underlying natural tissue while recovering both the structure and properties of natural healthy enamel.

Climate intervention may not be enough to save coffee, chocolate and wine

A new study published in Environmental Research Letters reveals that even advanced climate intervention strategies may not be enough to secure the future of wine grapes, coffee and cacao.

These crops are vital to many economies and provide livelihoods for farmers worldwide. However, they are increasingly vulnerable to the effects of . Rising temperatures and changing cause big variations in from year to year, meaning that farmers cannot rely on the stability of their harvest, and their produce is at risk.

The researchers specifically investigated Stratospheric Aerosol Injection (SAI) as a way of mitigating climate change in the top grape, coffee and cacao growing regions of western Europe, South America and West Africa. SAI is a hypothetical solar geoengineering method that involves releasing reflective particles into the stratosphere to cool Earth’s surface, mimicking the natural cooling effects of volcanic eruptions.

“This Is From a Meteorite”: Scientist Stunned by Water Inside 400-Million-Year-Old Plant

The research, led by Zachary Sharp, a professor in UNM’s Department of Earth and Planetary Sciences, was recently published in the Proceedings of the National Academy of Sciences (PNAS). The study centers on horsetails, a family of hollow-stemmed plants that have survived on Earth for more than 400 million years.

The researchers found that water moving through these plants experiences such a powerful natural purification process that its oxygen isotope composition closely matches that of meteorites and other materials from beyond our planet.

“It’s a meter-high cylinder with a million holes in it, equally spaced. It’s an engineering marvel,” Sharp said. “You couldn’t create anything like this in a laboratory.”

Menstrual cup upgrades: Self-cleaning and sustainable design adjustments could make them easier to use

Reusable menstrual cups reduce waste and are more cost-effective than single-use pads and tampons. But some people avoid the cups because they require thorough cleaning and are sometimes messy to empty. To solve these problems, researchers coated a commercially available silicone cup in silicone oil and created a plant-based, absorbent tablet. These design adjustments could make menstrual cups safer and easier to use, according to a study published in ACS Applied Materials & Interfaces.

“This research bridges advanced engineering and women’s health, creating a menstrual product that is not only self-cleaning and sustainable, but also opens doors for future health monitoring,” says Tohid Didar, one of the senior researchers of this study from McMaster University.

Nearly 2 billion people menstruate, and their desire for sustainable, reusable options—menstrual cups, disks and period underwear—is rising. Menstrual cups are designed to hold more fluid than tampons, allowing longer wear than the disposable option, and they can be cleaned and reused for years.

Engineered Immune Cells Improves Anti-Cancer Response

Scientists have developed a way to engineer immune cells that specifically target tumors. The application of engineering cells first appeared in the 1980s, but the concept has significantly progressed over the last few decades. This approach of engineering a patient’s cells as a form of therapy allow the immune system to specifically target the tumor and limit off-target affects.

Chimeric antigen receptor (CAR) T cells is an immunotherapy that takes patient T cells and edits them to target the tumor. The cells are then reinfused to accurately and effectively eliminate tumor growth. Immunotherapy is a general classification of cancer treatments that refers to the redirection of the immune system toward a disease or infection. T cells are responsible for the identification and elimination of infected cells and other diseases. Therefore, they are the optimal cell to engineer for robust and durable antitumor immunity. While scientists are working to engineer other cell types, CAR T cell therapy have been shown to have improved efficacy in multiple types of blood or hematological malignancies.

CAR T cell therapy in solid tumors is less effective. Unfortunately, the environment around the tumor has a complex network of various cell types combined with proteins and other molecules that inhibit CAR T cell efficacy. As a result, these CAR T cells cannot function and contribute to tumor progression. Scientists are currently working to improve CAR T cell therapy and develop stronger anti-cancer treatments.

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