Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: life extension – Page 130

Researchers at the University of Rochester have successfully exported a longevity gene from naked mole rats to mice – a transfer that resulted in both improved health and an extension of the mouse’s lifespan [1].

Longevity. Technology: Naked mole rats, which are known for their long lifespans and exceptional resistance to age-related diseases, have been a focus of longevity research for some time. By introducing a specific gene responsible for improved cellular repair and protection into mice, the Rochester researchers have created promising opportunities to better understand the mechanisms behind aging and potentially increase human lifespan.

“Our study provides a proof of principle that unique longevity mechanisms that evolved in long-lived mammalian species can be exported to improve the lifespans of other mammals,” says Vera Gorbunova, the Doris Johns Cherry Professor of biology and medicine at Rochester [2].

Read more | >

Scientists from the University of Rochester have had the naked mole-rat (Heterocephalus glaber) in their crosshairs for some time, previously identifying how their unique cellular aging mechanisms lay the foundation for their long lifespans – up to 41 years, during which the females also remain fertile – and resistance to age-related diseases.

The modification directly led to the improved overall health of the aging mice and an approximate 4.4% increase in median lifespan.

They weigh about an ounce, spend their lives underground in sub-Saharan Africa and are unlikely to be making the shortlist for any cute animal calendars, but the naked mole-rat continues to show scientists it has incredible age-resistant biology beneath its pale, wrinkly skin.

Building on that knowledge, the researchers genetically modified mice to produce the naked mole-rat version of the hyaluronan synthase 2 gene, which makes a protein that produces high molecular weight hyaluronic acid (HMW-HA). While all mammals have hyaluronan synthase 2, the naked mole-rat’s version is somehow enhanced, driving stronger gene expression.

Read more | >

Personalized regenerative medicine company Aspen Neuroscience has joined forces with Emerald Innovations and Rune Labs to integrate digital health monitoring technology into its Trial Ready Screening Cohort Study. The study, which began in 2022, seeks to identify potential patient candidates for a future clinical trial of Aspen’s personalized cell therapy (ANPD001) in Parkinson’s disease.

Aspen’s approach targets Parkinson’s disease by replenishing lost dopamine neurons, addressing both motor and non-motor symptoms of the disease. By combining cutting-edge biosensors, software analytics, and cellular therapies, the new collaboration aims to significantly improve the quality of life for those living with Parkinson’s disease.

Harnessing the capabilities of Emerald Innovations’ ‘invisible’ off-body sensors and Rune Labs’ precision neurology software, Aspen intends to bolster the collection of objective measures of motor function. The company says the partnership will enable long-term symptom capture, providing useful data on disease progression before treatment.

Read more | >

Hypotension is a common complication during general anesthesia associated with increased postoperative mortality and morbidity. Every episode of intraoperative hypotension, regardless of duration, is linked to the risk of acute kidney injury and cardiovascular events. The vulnerability to hemodynamic disturbances increases with age, underscoring the need for prompt interventions for elderly patients who experience hypotension during anaesthesia.

Using ephedrine resulted in a notable rise in mean arterial pressure (MAP) and cardiac output (CO). Still, no meaningful correlation with age was detected in patients aged 45 years or older. These results imply that ephedrine is reliable for managing low blood pressure during general anaesthesia, even in elderly patients, says Yuta Uemura in a recent study published in BMC Anesthesiology.

Ephedrine is a mixed α- and β-agonist vasopressor for correcting hypotension during general anaesthesia. β-responsiveness decreases with age; therefore, this study aimed to determine whether ageing would reduce the pressor effect of ephedrine on hypotension during general anaesthesia.

Read more | >

Scientists have found a way to reprogram human cells so that they mimic the highly plastic embryonic stem cells that have so much promise for use in regenerative medicine. By essentially wiping the cell’s “memory”, the team have created so-called induced pluripotent stem (iPS) cells, which could be used to regenerate or repair diseased tissue and organs.

IPS cells are a type of pluripotent cell that can be obtained by reprogramming mature human adult cells (“somatic” cells) into an embryonic stem cell-like state. This means that they have the capacity to differentiate into any cell of the body. They were first demonstrated in 2006, and have myriad potential biomedical and therapeutic uses, including disease modeling, drug screening, and cell-based therapies.

Despite this promise, researchers have continually hit a stumbling block that has prevented iPS cells from realizing their potential. “A persistent problem with the conventional reprograming process is that iPS cells can retain an epigenetic memory of their original somatic state, as well as other epigenetic abnormalities,” Professor Ryan Lister, lead author of a paper presenting the latest breakthrough, said in a statement.

Read more | >

In this video, we’ll dive deep into the cutting-edge research on how Artificial Intelligence (AI) and Artificial General Intelligence (AGI) are helping us to better understand the aging process and unlock the secrets to living forever.

We’ll discuss the latest breakthroughs in AI and AGI and how they are enabling researchers to analyze vast amounts of data, identify patterns, and make predictions that were once impossible. We’ll also explore how AI and AGI are being used to develop new treatments and therapies to prevent or reverse aging-related diseases within the Longevity Industry.

Read more | >