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Category: health

Mechanoluminescent sensors with dual-function polymer shell offer eco-friendly, high-resolution control

Mechanoluminescent (ML) materials are attractive for haptic interface sensors for next-generation technologies, including bite-controlled user interface, health care motion monitoring, and piconewton sensing, because they emit light under mechanical stimulation without an external power source. However, their intrinsically broad emission spectra can degrade resolution and introduce noise in sensing applications, necessitating further technological development.

Addressing this knowledge gap, a team of researchers from the Republic of Korea and the UK, led by Hyosung Choi, a Professor at the Department of Chemistry at Hanyang University, and including Nam Woo Kim, a master’s student at Hanyang University, recently employed a chromatic filtration strategy to pave the way to high-resolution ML haptic sensors. Their findings are published in the journal Advanced Materials.

In this study, the team coated the conjugated polymer poly(9,9-dioctylfluorene-alt-benzothiadiazole) (F8BT) onto ZnS: Cu to selectively suppress emission below 490 nm, narrowing the full width at half maximum from 94 nm to 55 nm.

As brain organoids grow increasingly complex, leading scientists and bioethicists call for global oversight

In an effort to address these ethical grey areas, 17 leading scientists and bioethicists from five countries are urging the establishment of an international oversight body to monitor advances in the rapidly expanding field of human neural organoids and to provide ethical and policy guidance as the science continues to evolve. The call to action, published Thursday in Science, comes as U.S. government agencies are making new investments in organoid science aimed at accelerating drug discovery and reducing reliance on animal models of disease.

In September, the National Institutes of Health announced $87 million in initial contracts to establish a new center dedicated to standardizing organoid research. The move followed an earlier pledge by both the NIH and the Food and Drug Administration to reduce, and possibly replace, testing on mice, primates, and other animals with other methods — including organoids and organ-on-a-chip technologies — for developing certain medicines.

Government promotion of human stem cell models more broadly will only increase the recruitment of new researchers into the field of neural organoids, which has seen an explosion from a few dozen labs a decade ago to hundreds around the world now, said Sergiu Pasca, a pioneering neuroscientist and stem cell biologist at Stanford University who co-authored the Science commentary.

Coordinating health AI to prevent defensive escalation

Artificial intelligence (AI) systems that can analyse medical images, records, and claims are becoming accessible to everyone. Although these systems outperform physicians at specific tasks, such as detecting cancer on CT scans, they are still imperfect. But as AI performance progresses from occasionally correct to reliably superior, there will be increasing pressure to conform to algorithmic outputs.

United Nations General Assembly’s AUDACITY 100 Disruptors Summit

face_with_colon_three Fungi can save all life on earth. This lecture teaches that mushrooms are outperforming even age old medicines.

Watch my 15 minute speech at the United Nations General Assembly’s AUDACITY 100 Disruptors Summit was a powerful reminder of how interconnected we all are.

I spoke about how fungal mycelium can help heal ecosystems, strengthen food systems, and strengthens the health.
of the residents of the planet. Mycelium supports our collective immunity.

When Mycelium Running: How Mushrooms Can Help Save the World was published in 2005, it foretold the mycelial revolution that continues to sweep the planet. This book is as relevant today as it was then. What has happened since? The scientific community continues to verify that mycelium is essential for our collective health, whether as nutritional supplements, or as the core fabric of our food webs.

Common Sweetener Could Damage Critical Brain Barrier, Risking Stroke

Found in everything from protein bars to energy drinks, erythritol has long been considered a safe alternative to sugar.

But research suggests this widely used sweetener may be quietly undermining one of the body’s most crucial protective barriers – with potentially serious consequences for heart health and stroke risk.

A study from the University of Colorado suggests erythritol may damage cells in the blood-brain barrier, the brain’s security system that keeps out harmful substances while letting in nutrients.

New antibiotic for drug-resistant bacteria found hiding in plain sight

Chemists from the University of Warwick and Monash University have discovered a promising new antibiotic that shows activity against drug-resistant bacterial pathogens, including MRSA and VRE.

Antimicrobial resistance (AMR) is one of the world’s most urgent health challenges, with the WHO’s new report showing there are ‘too few antibacterials in the pipeline’. Most of the ‘low-hanging fruit’ has already been found, and the limited commercial incentives deter investment in antibiotic discovery.

In a new study published in the Journal of the American Chemical Society, researchers from the Monash Warwick Alliance Combatting Emerging Superbug Threats Initiative have discovered a promising new antibiotic — pre-methylenomycin C lactone. The newly discovered antibiotic was ‘hiding in plain sight’ – as an intermediate chemical in the natural process that produces the well-known antibiotic methylenomycin A.

Precision medicine intervention found to ease symptoms of a depression biotype

Depression is one of the most widespread mental health disorders worldwide, characterized by persistent feelings of sadness, a loss of interest in everyday activities, dysregulated sleep or eating patterns and other impairments. Some individuals diagnosed with depression also report being unable to pay attention during specific tasks, while also experiencing difficulties in planning and making decisions.

Recent studies have uncovered different biotypes of depression, subgroups of patients diagnosed with the condition that exhibit similar neural circuit patterns and behaviors. One of these subtypes is the so-called “cognitive biotype,” which is linked to a reduced ability to focus attention and inhibit distractions or unhelpful thinking patterns.

Researchers at Stanford University School of Medicine and the VA Palo Alto Health Care System recently carried out a study assessing the potential of guanfacine immediate release (GIR), a medication targeting known to be impaired in people with the cognitive biotype of depression.

Ultra-thin 3D display delivers wide-angle, highly-detailed images

Researchers have developed an ultra-thin 3D display with a wide viewing angle, clear image quality and vivid display depth. By overcoming tradeoffs that typically limit glasses-free 3D displays, the advance could open new possibilities for highly detailed interactive experiences in health care, education and entertainment.

“The new display is just 28 mm thick, dramatically slimmer than conventional directional backlight systems, which typically exceed 500 mm,” said research team leader Xu Liu, from Zhejiang University in China. “This level of compactness, combined with the substantial boost in resolution we achieved, represents an important step toward making the technology practical for real-world products.”

In Optica, the researchers demonstrate an ultra-slim 32-inch directional backlight-based prototype based on the new display design. The prototype is roughly the size of a large computer monitor, has a wide viewing angle of over 120° and a large 3D display volume of 28 × 16 × 39 inches.

Experts warn of wider health impact of tropical cyclones in a warming climate

Beyond direct injuries, exposure to tropical cyclones is associated with higher risks of death across a range of causes including kidney, heart and lung diseases, neuropsychiatric conditions, and diabetes, finds a study published in The BMJ’s climate issue.

Risks were substantially higher in deprived communities and areas that have previously experienced fewer tropical cyclones, suggesting an urgent need to integrate more evidence on into disaster response plans, say the authors.

Tropical cyclones are one of the most devastating and costly extreme weather events, affecting an average of 20.4 million people a year with direct economic losses of US$51.5 billion over the past decade.

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