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Apical periodontitis, a chronic and hard-to-treat dental infection, affects more than half of the population worldwide and is the leading cause of tooth loss. Root canal is the standard treatment, but existing approaches to treat the infection have many limitations that can cause complications, leading to treatment failure.

Now, researchers at the School of Dental Medicine, Perelman School of Medicine, and School of Engineering and Applied Sciences have identified a promising new therapeutic option that could potentially disrupt current treatments. The team of researchers is part of the Center for Innovation & Precision Dentistry, a joint research center between Penn Dental Medicine and Penn Engineering that leverages engineering and computational approaches to advance oral and craniofacial health care innovation.

In a paper published in the Journal of Clinical Investigation, they show that ferumoxytol, an FDA-approved iron oxide nanoparticle formulation, greatly reduces infection in patients diagnosed with apical periodontitis.

Dr. Douglas Colquhoun: “Inhaled anesthetics are a natural area to pursue reductions in emissions because, as greenhouse gases, they are so disproportionately bad for the environment.”


How can greener anesthesia help both patients and the environment? This is what a recent study published in The Lancer Planetary Health hopes to address as a team of researchers at the University of Michigan (U-M) Medical School investigated a multitude of benefits regarding the use of anesthesia free of pollutants and greenhouse gases, which they are traditionally known to contain. This study has the potential to help researchers, medical professionals, legislators, and the public better understand the benefits of providing patients with “greener” anesthesia, along with the environmental benefits, as well.

For the study, the researchers started the Green Anesthesia Initiative (GAIA) in March 2022 to monitor the use of pollutant-free—such as nitrous oxide—anesthesia aged 1 year and older between March 1, 2021, and February 28, 2023. The goal of GAIA was to ascertain patient health and environmental impact resulting from this new anesthetic treatment. In the end, the researchers monitored 45,692 patients (50.8 percent women and 49.2 percent men) before GAIA and 47,199 patients (also 50.8 percent women and 49.2 percent men) after GAIA, with results showing a 14.38 kilograms (31.7 pounds) per patient reduction in carbon dioxide emissions.

“Tens of thousands of people undergo general anesthesia at Michigan Medicine every year,” said Dr. Douglas Colquhoun, who is an assistant professor of anesthesiology at U-M Medical School and lead author of the study. “Inhaled anesthetics are a natural area to pursue reductions in emissions because, as greenhouse gases, they are so disproportionately bad for the environment. We’ve shown that small changes in our practice lead to big changes for the environment and, importantly, no changes for the patients.”

The future is coming and much faster than we think. Let’s do an exercise of imagination, imagine, for a moment, being able to send information from one point to another without the need for cables, Wi-Fi or traditional signals, more or less like something telepathic, right? Well, that is precisely what scientists have recently achieved at the University of Oxford: teleporting data between two quantum computers. Although it may seem like science fiction or just news, the world.

Although, let’s lower the hype a little, the transmission distance of this experiment was less than two meters, but that doesn’t matter, what matters is having achieved this milestone of sharing information without the need for connections.

Summary: New research reveals the heart has its own complex nervous system, or “mini-brain,” capable of regulating the heartbeat independently of the brain. Conducted on zebrafish, the study identified specialized neurons within the heart, including some with pacemaker properties, challenging traditional views of heartbeat control.

This discovery provides new insights into heart diseases and potential treatments for conditions like arrhythmias. Researchers aim to explore how this cardiac nervous system interacts with the brain during stress, exercise, or disease to identify novel therapeutic targets.

New in JNeurosci: Researchers identified a new subset of neurons in mice that morphine may interact with to influence behavior. This neuron population could be a promising new opioid addiction treatment target.

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Opioid use disorder constitutes a major health and economic burden, but our limited understanding of the underlying neurobiology impedes better interventions. Alteration in the activity and output of dopamine (DA) neurons in the ventral tegmental area (VTA) contributes to drug effects, but the mechanisms underlying these changes remain relatively unexplored. We used translating ribosome affinity purification and RNA sequencing to identify gene expression changes in mouse VTA DA neurons following chronic morphine exposure. We found that expression of the neuropeptide neuromedin S (Nms) is robustly increased in VTA DA neurons by morphine. Using an NMS-iCre driver line, we confirmed that a subset of VTA neurons express NMS and that chemogenetic modulation of VTA NMS neuron activity altered morphine responses in male and female mice. Specifically, VTA NMS neuronal activation promoted morphine locomotor activity while inhibition reduced morphine locomotor activity and conditioned place preference (CPP). Interestingly, these effects appear specific to morphine, as modulation of VTA NMS activity did not affect cocaine behaviors, consistent with our data that cocaine administration does not increase VTA Nms expression. Chemogenetic manipulation of VTA neurons that express glucagon-like peptide, a transcript also robustly increased in VTA DA neurons by morphine, does not alter morphine-elicited behavior, further highlighting the functional relevance of VTA NMS-expressing neurons. Together, our current data suggest that NMS-expressing neurons represent a novel subset of VTA neurons that may be functionally relevant for morphine responses and support the utility of cell type-specific analyses like TRAP to identify neuronal adaptations underlying substance use disorder.

Significance Statement The opioid epidemic remains prevalent in the U.S., with more than 70% of overdose deaths caused by opioids. The ventral tegmental area (VTA) is responsible for regulating reward behavior. Although drugs of abuse can alter VTA dopaminergic neuron function, the underlying mechanisms have yet to be fully explored. This is partially due to the cellular heterogeneity of the VTA. Here, we identify a novel subset of VTA neurons that express the neuropeptide neuromedin S (NMS). Nms expression is robustly increased by morphine and alteration of VTA NMS neuronal activity is sufficient to alter morphine-elicited behaviors. Our findings are the first to implicate NMS-expressing neurons in drug behavior and thereby improve our understanding of opioid-induced adaptations in the VTA.

Glaciers separate from the continental ice sheets in Greenland and Antarctica covered a global area of approximately 706,000 km2 around the year 200019, with an estimated total volume of 158,170 ± 41,030 km3, equivalent to a potential sea-level rise of 324 ± 84 mm (ref. 20). Glaciers are integral components of Earth’s climate and hydrologic system1. Hence, glacier monitoring is essential for understanding and assessing ongoing changes21,22, providing a basis for impact2,3,4,5,6,7,8,9,10 and modelling11,12,13 studies, and helping to track progress on limiting climate change23. The four main observation methods to derive glacier mass changes include glaciological measurements, digital elevation model (DEM) differencing, altimetry and gravimetry. Additional concepts include hybrid approaches that combine different observation methods. In situ glaciological measurements have been carried out at about 500 unevenly distributed glaciers24, representing less than 1% of Earth’s glaciers19. Glaciological time series provide seasonal-to-annual variability of glacier mass changes25. Although these are generally well correlated regionally, long-term trends of individual glaciers might not always be representative of a given region. Spaceborne observations complement in situ measurements, allowing for glacier monitoring at global scale over recent decades. Several optical and radar sensors allow the derivation of DEMs, which reflect the glacier surface topography. Repeat mapping and calculation of DEM differences provide multi-annual trends in elevation and volume changes26 for all glaciers in the world27. Similarly, laser and radar altimetry determine elevation changes along linear tracks, which can be extrapolated to calculate regional estimates of glacier elevation and volume change28. Unlike DEM differencing, altimetry provides spatially sparse observations but has a high (that is, monthly to annual) temporal resolution26. DEM differencing and altimetry require converting glacier volume to mass changes using density assumptions29. Satellite gravimetry estimates regional glacier mass changes at monthly resolution by measuring changes in Earth’s gravitational field after correcting for solid Earth and hydrological effects30,31. Although satellite gravimetry provides high temporal resolution and direct estimates of mass, it has a spatial resolution of a few hundred kilometres, which is several orders of magnitude lower than DEM differencing or altimetry26.

The heterogeneity of these observation methods in terms of spatial, temporal and observational characteristics, the diversity of approaches within a given method, and the lack of homogenization challenged past assessments of glacier mass changes. In the Intergovernmental Panel on Climate Change (IPCC)’s Sixth Assessment Report (AR6)16, for example, glacier mass changes for the period from 2000 to 2019 relied on DEM differencing from a limited number of global27 and regional studies16. Results from a combination of glaciological and DEM differencing25 as well as from gravimetry30 were used for comparison only. The report calculated regional estimates over a specific baseline period (2000–2019) and as mean mass-change rates based on selected studies per region, which only partly considered the strengths and limitations of the different observation methods.

The spread of reported results—many outside uncertainty margins—and recent updates from different observation methods afford an opportunity to assess regional and global glacier mass loss with a community-led effort. Within the Glacier Mass Balance Intercomparison Exercise (GlaMBIE; https://glambie.org), we collected, homogenized and combined regional results from the observation methods described above to yield a global assessment towards the upcoming IPCC reports of the seventh assessment cycle. At the same time, GlaMBIE provides insights into regional trends and interannual variabilities, quantifies the differences among observation methods, tracks observations within the range of projections, and delivers a refined observational baseline for future impact and modelling studies.

Ancient texts warn of love turning into hatred, as seen in stories like Cain and Abel or “Et tu, Brute?” This talk explores the neurobiology of hatred based on the biology of love: the oxytocin system, attachment networks, and biobehavioral synchrony, which mature through mother-infant bonding and later support group solidarity and out-group hostility. Using this model, we developed Tools of Dialogue© for Israeli and Palestinian youth. After 8 sessions, participants showed reduced hostility, increased empathy, hormonal changes (lower cortisol, higher oxytocin), and lasting attitudes of compromise. Seven years later, these changes supported their peacebuilding efforts, showing how social synchrony can transform hatred into reciprocity and cooperation. Recorded on 02/14/2025. [Show ID: 40386]

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Learn more about anthropogeny on CARTA’s website:
https://carta.anthropogeny.org/

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Forever chemicals affect your genes, according to a recent study.

Scientists have identified 11 genes that are consistently impacted by exposure to harmful chemicals that are found in everything from drinking water to food packaging.

Forever chemicals, also known as PFAS, are a global health concern. PFAS or “per-and poly-fluorinated alkyl substances” are also found in common household objects such as non-stick pans, stain or water-resistant materials as well as paints, carpets and clothes.

They are persistent in the environment and can accumulate in our bodies over time. They have been linked to a range of negative health outcomes, including impacting our genes. Some of the 11 genes that were impacted by PFAS are vital for neuronal health, and they showed altered expression levels after exposure to PFAS compounds. This discovery suggests these genes could serve as potential markers for detecting and monitoring PFAS-induced neurotoxicity.

However, the study also revealed that hundreds of other genes responded differently depending on the exact PFAS compound. While PFAS are known to accumulate in the brain due to their ability to cross the blood-brain barrier, this research provides new insights into the intricate ways these chemicals can interfere with gene expression and potentially disrupt our health. Concerns about PFAS stem from their potential health effects, which may include immune deficiency, liver cancer, and thyroid abnormalities. Due to their persistence and potential health risks, many governments are taking steps to regulate or ban the use of PFAS in various products.

Researchers have developed a new, highly effective “gene switch” to deliver targeted cell therapy.

The ETH Zurich team states that this cell therapy has the potential to offer a more precise and personalized treatment for diabetes.

Diabetes is a major global health concern, classified as a metabolic disease and affecting about one in ten individuals.