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Single enzyme streamlines production of all four RNA building blocks

A single enzyme that can generate all four nucleoside triphosphates, the building blocks of ribonucleic acid (RNA), has been identified by researchers at the Institute of Science Tokyo. The study was published online in the journal Nature Communications.

By using polyphosphate as a phosphate donor, the enzyme efficiently converts inexpensive nucleotide precursors into the active forms required for RNA synthesis. Overall, the method dramatically simplifies the process of nucleotide production—offering a low-cost, efficient option for the in vitro synthesis of RNA.

Not just a pain in the bone

In a new Science study, researchers report an unexpected role for sensory nerves in bone healing, providing insights into communication between the nervous system and the cells responsible for bone repair.

Learn more in a new Science Perspective.


Growth factors secreted by sensory nerves promote fracture healing.

Vicki Rosen and Francesca Gori Authors Info & Affiliations

Science

Vol 391, Issue 6781

A Very Stable Mirror

To make an ultrastable laser beam for applications such as gravitational-wave detectors, the frequency of a beam confined within an optical cavity is locked to the cavity’s resonant frequency. This frequency is determined by the cavity’s length. The stability of the laser beam’s frequency and the quality of the cavity’s resonance depend on the thermal noise of the mirrors that define that length. Dahyeon Lee at JILA and the University of Colorado Boulder and his colleagues have now demonstrated a crystalline mirror coating with superior thermomechanical properties compared to conventional coatings [1]. The new coating could lead to ultrastable cavities for optical clocks and next-generation interferometers.

Recently, mirrors coated with crystalline alloys of gallium arsenide (GaAs) have emerged as promising candidates to replace those with conventional amorphous dielectric coatings. GaAs-coated mirrors have excellent optical qualities and exhibit low thermal noise at room temperature. But previous studies found that these crystalline coatings suffer from additional noise contributions, which undermine their potential usefulness.

The origins of some of those noise contributions remain unclear. Nevertheless, Lee and colleagues have demonstrated that crystalline GaAs-based coatings can still be superior at cryogenic temperatures. The researchers constructed a 6-cm-long cavity bounded by two mirrors made of alternating layers of GaAs and aluminum gallium arsenide on silicon substrates. They used more layers compared to previous experiments, which reduced photon loss. Operating the cavity at 17 K, where the thermal expansion coefficient of the silicon substrate is zero, they achieved a frequency stability of 2.5 × 10−17. This stability is 4 times better than the expected limit for conventional coatings and sets a new record for cavity-stabilized lasers.

2.8 Days to Disaster: Low Earth Orbit Could Collapse Without Warning

A new analysis suggests modern satellite networks could suffer catastrophic collisions within days of losing control during a major solar storm. The phrase “House of Cards” is often associated today with a Netflix political drama, but its original meaning refers to a structure that is inherently

Gigantic Wave in The Pacific Was The Most Extreme ‘Rogue Wave’ on Record

In November 2020, a freak wave appeared, lifting a lone buoy off the coast of British Columbia 17.6 meters (58 feet) high.

A few years later, the four-story wall of water was confirmed to be the most extreme rogue wave ever recorded.

Such an extraordinary event is thought to happen only once every 1,300 years. And if the buoy hadn’t been taken for a ride, we might never have known it had occurred.

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