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Microgravity rewires microbial metabolism, limiting space-based manufacturing efficiency

Scientists at the U.S. Naval Research Laboratory (NRL) have completed a spaceflight biology investigation aboard the International Space Station (ISS) that reveals how microgravity fundamentally alters microbial metabolism, limiting the efficiency of biological manufacturing processes critical to future long-duration space missions. The findings were recently published in the journal npj Microgravity.

The Melanized Microbes for Multiple Uses in Space Project (MELSP), launched to the space station in November 2023, examined how microgravity affects the ability of engineered microbes to produce melanin, a multifunctional biopolymer known for its radiation-shielding, antioxidant, and thermal stable properties.

Results from the completed mission show that while microbes remain capable of producing melanin in space, microgravity significantly interferes with substrate transport, cellular stress responses, and metabolic balance, ultimately reducing production efficiency.

Sloshing liquefied natural gas in cargo tanks causes higher impact forces than expected

What happens if liquefied natural gas (LNG) hits the wall of the cargo tanks in a ship? New research from the team of physicist Devaraj van der Meer from the University of Twente, published in the Proceedings of the National Academy of Sciences, shows that much higher pressure peaks can occur during impact than previously assumed. This insight is important for the design and safety of LNG ships and future liquid hydrogen transport systems.

Normally, a thin layer of air prevents a liquid from hitting a surface directly. The gas acts as a cushion and dampens the blow. In LNG ships, that air has been replaced by vapor from the LNG itself. And that vapor can condense back into liquid during impact. As a result, the cushion disappears, and the load on the wall increases sharply.

Morphological characteristics of healthy and aneurysmal internal carotid artery bifurcations

Internal carotid artery (ICA) bifurcation (ICAB) aneurysms carry high rupture risk, treatment challenges, and recurrence due to complex morphology and origination patterns. Given their relatively low incidence, research on ICAB morphology is limited. This study analyzed ICAB morphology in aneurysmal, contralateral, and healthy bifurcations, highlighting bilateral differences, anterior cerebral artery (ACA) dominance, and deviations from the vascular optimality principle (VOP).

A total of 194 angiographic volumes (40 aneurysmal, 28 contralateral, 126 healthy) were evaluated. ICAB morphology included parent/daughter vessel diameters and angle between the ICA and middle cerebral artery (MCA; ФMCA), angle between the ICA and ACA (ФACA), total ICAB angle (ФICAB; ФMCA + ФACA). Aneurysm characteristics (size, neck, origination) and VOP parameters (radius ratio [RR] and junction exponent [n]) were evaluated. Bilateral analysis accounted for ACA dominance.

Compared with controls, aneurysmal ICABs exhibited wider ΦMCA (57.22° ± 12.22° vs 43.74° ± 9.41°, p < 0.001; area under the curve [AUC] = 0.83) and ΦICAB (160.27° ± 16.16° vs 143.66° ± 10.74°, p < 0.001; AUC = 0.79), but not ΦACA, in univariate, multivariate (AUC = 0.85), and bilateral analyses. Angle thresholds of 51.7° for ΦMCA and 152.4° for ΦICAB were identified. Aneurysms originated predominantly off the apex (65%) and ACA (30%). Most occurred on ICABs with dominant (31%) and codominant (58%) A1 segments. Aneurysm neck, but not size, correlated with ΦMCA and ΦICAB, but not ΦACA. In controls, ΦMCA was larger and ΦACA smaller on the dominant A1 side, with no ΦICAB difference. There was no statistically significant difference in RR and n values regardless of aneurysm presence and dominance status.

Conscious AI: Conflations and Comparisons

Consciousness, like intelligence, is multi-faceted. This makes the future of AI more unpredictable and potentially even more hazardous.

When considering AIs that might be conscious, the first great conflation is to fail to distinguish between intelligence and consciousness. The suggestion is that something which is as generally intelligent as a human is bound to be as conscious as a human. General intelligence and consciousness are both intrinsic features of an advanced mind, right?

Well, no. Of course not. There’s no fundamental necessity for these two characteristics to be tightly bound together. A chatbot can provide a human companion with sparkling conversation without having its own inner sparkle of feeling. Like an actor, it can mimic expressions of emotional highs and lows whilst lacking any interior passion. It can talk persuasively about having an inner life without there being any inside inside.

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