Qu et al. identify HRD1 as a key negative regulator of autophagosome-lysosome fusion. They demonstrate that HRD1 interacts with the SNARE protein SNAP29 to suppress its liquid-liquid phase separation. This work establishes the regulation of SNARE complex assembly via phase separation as a critical control mechanism for autophagy progression.
🛰️Future Day is coming soon ⚡️
Participants include: Anders Sandberg, Ben Goertzel, Hugo de Garis, Roman Yampolskiy, Lev Lafayette, Adam Ford, Christine Peterson, Robin Hanson, Aubrey de Grey, Joscha Bach, James Hughes and Danica Dillion.
Live from Australia! This time we have Future Day spanning 3 days – from March 2nd to March 4nd AEDT – from March 1st to March 5th PST.
Why not celebrate the amazing future we are collectively creating?
Future Day 2026 -> where the future isn’t just discussed, but actively shaped.
It sits more than 2 miles (3.2 kilometers) down, so the current push likely comes from gases above it rather than fresh magma reaching the surface.
The pattern looks like a slow squeeze. First the ground rose, then it steadied as new cracks opened and some gas found exit paths.
Taftan volcano is a 12,927 foot (3,940 meter) stratovolcano, a steep volcano that is built of layers of lava and ash. It vents through summit fumaroles – volcanic vents that emit gas – which shows the system still moves.
Plant-derived THC extracts significantly reduced fibromyalgia pain in patients resistant to standard treatments. [ https://www.labroots.com/trending/cannabis-sciences/30219/pl…gia-pain-2](https://www.labroots.com/trending/cannabis-sciences/30219/pl…gia-pain-2)
How can cannabis oil help alleviate fibromyalgia pain? This is what a recent study published in the Journal of Anesthesia, Analgesia, and Critical Care hopes to address as a team of researchers from Italy investigated the benefits of using tetrahydrocannabinol (THC)-based medicine options, specifically cannabis oil, for treating fibromyalgia pain. This study has the potential to help researchers, medical professionals, legislators, and the public better understand the benefits of using cannabis products for treating chronic diseases over prescriptions medications, and the steps that can be taken to implement them.
For the study, the researchers analyzed data obtained from 65 adult patients comprised of 59 women and 6 men diagnosed with fibromyalgia for a minimum of 7 years and were treated with cannabis oil therapy with a concentration of 15 percent from 2021 to 2023. The goal of the study was to ascertain the effectiveness of cannabis oil on mitigating fibromyalgia pain compared to traditional methods, specifically prescription medication. In the end, the researchers found that not only did the patients report decreased fibromyalgia pain during cannabis oil therapy, but this pain reduction was greater with younger patients.
The study notes, “While these observations should not be interpreted as evidence of effectiveness, they contribute real-world insights into tolerability and adherence in routine care. We hope they may help inform future prospective research aimed at better defining the role of cannabis oil in fibromyalgia management.”
Developer Puck released the Pixelizer tool to add retro aesthetics to your 3D props.
Spinosaurs have sometimes been portrayed as swimmers or divers, but a new species of these dinosaurs bolsters the idea that they were more like gigantic herons
Online now: Wessendorf-Rodriguez et al. develop a pipeline for applying metabolic flux analysis to quantify lipid homeostasis. Lipid-MFA elucidates differences in synthesis and salvage fluxes in precision-cut lung slices harboring tumors with common driver mutations of lung adenocarcinoma. Application of Lipid-MFA reveals distinct trafficking of ceramide species into the sphingolipidome.