Researchers have developed very light and extremely strong material that can withstand extreme heat. The material could be useful for aerospace and other high-performance industries.
Developed by researchers from University of Toronto Engineering, the material can withstand temperatures up to 932°F (500° C).
The new composite material is made of various metallic alloys and nanoscale precipitates, and has a structure that mimics that of reinforced concrete, but on a microscopic scale.
Consciousness is fundamental; only thereafter do time, space and matter arise. This is the starting point for a new theoretical model of the nature of reality, presented by Maria Strømme, Professor of Materials Science at Uppsala University, in AIP Advances. The article has been selected as the best paper of the issue and featured on the cover.
Strømme, who normally conducts research in nanotechnology, here takes a major leap from the smallest scales to the very largest—and proposes an entirely new theory of the origin of the universe. The article presents a framework in which consciousness is not viewed as a byproduct of brain activity, but as a fundamental field underlying everything we experience—matter, space, time, and life itself.
Via OPG_BOEx: Clinical translation of photoacoustic imaging using exogenous molecular contrast agents [Invited] https://bit.ly/4occZgi
A team from Rice University examines the current status and future potential of contrast-enhanced PAI in human applications.
In their results, the team proposed neuro-oncology as a novel application, effectively addressing the limitations of intraoperative fluorescence imaging.
Photoacoustic imaging (PAI) combines optical contrast with acoustic detection to enable high-resolution, molecular imaging at clinically relevant depths. This review outlines the current status and future potential of contrast-enhanced PAI in human applications. We begin by discussing regulatory considerations surrounding both imaging devices and exogenous contrast agents, highlighting safety concerns, lack of standardized validation protocols, and barriers to the approval of novel agents. To accelerate clinical adoption, many studies have focused on repurposing FDA-approved agents such as indocyanine green, methylene blue, and clofazimine, which offer favorable optical properties and known safety profiles. We then review clinical applications of contrast-enhanced PAI across organ systems. In lymphatic imaging, PAI enables noninvasive visualization of lymphatic vessels and sentinel lymph nodes. Prostate imaging benefits from improved tumor delineation, and vascular applications leverage PAI to assess oxygen saturation and vascular remodeling. In gastrointestinal and hepatic imaging, PAI supports functional assessment and lesion detection with enhanced contrast. Emerging applications in neuro-oncology demonstrate the potential of PAI for intraoperative guidance and brain tumor imaging. Compared to fluorescence imaging, PAI provides deeper penetration and quantifiable contrast. Studies using both approved and investigational agents, including gold nanorods and targeted dye conjugates, highlight advances in imaging tumor margins. Progress in transcranial PAI and molecular probe design continues to broaden its capabilities. Together, these developments underscore the expanding clinical utility of contrast-enhanced PAI for real-time, functional, and molecular imaging.
Researchers discovered a new way to independently tune a nanoparticle’s speed and direction using different strength electric fields.
The new method could lead to better drug delivery technologies.
Read more.
A new method using a combination of strong and weak electric fields to change nanoparticle speed and direction could improve drug delivery and purification systems.
Rapidly expanding advances in computational prediction capabilities have led to the identification of many potential materials that were previously unknown, including millions of solid-state compounds and hundreds of nanoparticles with complex compositions and morphologies. Autonomous workflows are being developed to accelerate experimental validation of these bulk and nanoscale materials through synthesis. For colloidal nanoparticles, such strategies have focused primarily on compositionally simple systems, due in part to limitations in the generalizability of chemical reactions and incompatibilities between automated setups and mainstream laboratory methods. As a result, the scope of theoretical versus synthesizable materials is rapidly diverging. Here, we use a simple automated platform to drive a massively generalizable reaction capable of producing more than 651 quadrillion distinct core@multishell nanoparticles using a single set of reaction conditions. As a strategic model system, we chose a family of seven isostructural layered rare earth (RE) oxychloride compounds, REOCl (RE = La, Ce, Pr, Nd, Sm, Gd, Dy), which are well-known 2D materials with composition-dependent optical, electronic, and catalytic properties. By integrating a computer-driven, hobbyist-level pump system with a laboratory-scale synthesis setup, we could grow up to 20 REOCl shells in any sequence on a REOCl nanoparticle core. Reagent injection sequences were programmed to introduce composition gradients, luminescent dopants, and binary through high-entropy solid solutions, which expands the library to a near-infinite scope. We also used ChatGPT to randomly select several core@multishell nanoparticle targets within predefined constraints and then direct the automated setup to synthesize them. This platform, which includes both massively generalizable nanochemical reactions and laboratory-scale automated synthesis, is poised for plug-and-play integration into autonomous materials discovery workflows to expand the translation of prediction to realization through efficient synthesis.
Researchers at Washington University School of Medicine in St. Louis, along with collaborators at Northwestern University, have developed a noninvasive approach to treat one of the most aggressive and deadly brain cancers. Their technology uses precisely engineered structures assembled from nano-size materials to deliver potent tumor-fighting medicine to the brain through nasal drops. The novel delivery method is less invasive than similar treatments in development and was shown in mice to effectively treat glioblastoma by boosting the brain’s immune response.
In January, a team led by Jim Schuck, professor of mechanical engineering at Columbia Engineering, developed a method for creating entangled photon pairs, a critical component of emerging quantum technologies, using a crystalline device just 3.4 micrometers thick.
Now, in a paper published in Nature Photonics in October, Columbia Engineers have shrunk nonlinear platforms with high efficiency down to just 160 nanometers by introducing metasurfaces: artificial geometries etched into ultrathin crystals that imbue them with new optical properties.
“We’ve established a successful recipe to pattern ultrathin crystals at the nanoscale to enhance nonlinearity while maintaining their sub-wavelength-thickness,” said corresponding author Chiara Trovatello is currently an assistant professor at Politecnico di Milano and was a Marie Skłodowska-Curie Global Fellow at Columbia working with Schuck.
An environmental chemistry laboratory at Duke University has solved a longstanding mystery of the origin of high levels of PFAS—so-called “forever chemicals”—contaminating water sources in the Piedmont region of North Carolina.
By sampling and analyzing sewage in and around Burlington, NC, the researchers traced the chemicals to a local textile manufacturing plant. The source remained hidden for years because the facility was not releasing chemical forms of PFAS that are regulated and monitored. The culprit was instead solid nanoparticle PFAS “precursors” that degrade into the chemicals that current tests are designed to detect.
Incredibly, these precursors were being released into the sewer system at concentrations up to 12 million parts-per-trillion—approximately 3 million times greater than the Environmental Protection Agency’s recently-enacted drinking water regulatory limit for certain types of PFAS.