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Category: nanotechnology

AI-generated sensors open new paths for early cancer detection

Detecting cancer in the earliest stages could dramatically reduce cancer deaths because cancers are usually easier to treat when caught early. To help achieve that goal, MIT and Microsoft researchers are using artificial intelligence to design molecular sensors for early detection.

The researchers developed an AI model to design peptides (short proteins) that are targeted by enzymes called proteases, which are overactive in cancer cells. Nanoparticles coated with these peptides can act as sensors that give off a signal if cancer-linked proteases are present anywhere in the body.

Depending on which proteases are detected, doctors would be able to diagnose the particular type of cancer that is present. These signals could be detected using a simple urine test that could even be done at home.

Washing machine filter captures microfibers as small as 20 micrometers in size

A single laundry load containing synthetic clothing can release thousands of plastic microfibers from nylon, acrylic and polyester materials. Lab testing of an SA-made washing machine filter at Flinders University shows it can be a useful new way to help protect waterways from polyester and other synthetic microparticles.

Flinders researchers are also developing a novel approach to enhance nanoplastic capture on cellulose filters using a plasma polymer coating.

Microplastics are plastic particles less than 5 mm wide, and they break down further to nanoparticles.

Scientists outline how to control light at the atomic scale using polaritons

Controlling light at dimensions thousands of times smaller than the thickness of a human hair is one of the pillars of modern nanotechnology.

An international team led by the Quantum Nano-Optics Group of the University of Oviedo and the Nanomaterials and Nanotechnology Research Center (CINN/Principalty of Asturias-CSIC) has published a review article in Nature Nanotechnology detailing how to manipulate fundamental optical phenomena when light couples to matter in atomically thin materials.

The study focuses on polaritons, hybrid quasiparticles that emerge when light and matter interact intensely. By using low-symmetry materials, known as van der Waals materials, light ceases to propagate in a conventional way and instead travels along specific directions, a characteristic that gives rise to phenomena that challenge conventional optics.

Nanoparticle therapy reprograms tumor immune cells to attack cancer from within

Within tumors in the human body, there are immune cells (macrophages) capable of fighting cancer, but they have been unable to perform their roles properly due to suppression by the tumor. A KAIST research team led by Professor Ji-Ho Park of the Department of Bio and Brain Engineering have overcome this limitation by developing a new therapeutic approach that directly converts immune cells inside tumors into anticancer cell therapies.

In their approach, when a drug is injected directly into a tumor, macrophages already present in the body absorb it, produce CAR (a cancer-recognizing device) proteins on their own, and are converted into anticancer immune cells known as “CAR-macrophages.” The paper is published in the journal ACS Nano.

Solid tumors —such as gastric, lung, and liver cancers—grow as dense masses, making it difficult for immune cells to infiltrate tumors or maintain their function. As a result, the effectiveness of existing immune cell therapies has been limited.

Electromagnetic wireless remote control of mammalian transgene expression

An intriguing paper by Lin et al. where cells were engineered to express a signaling pathway that transcribes a gene of interest upon generation of reactive oxygen species (ROS) by CBCFO nanoparticles in response to applied electromagnetic fields. When implanted in a mouse model of diabetes, nanoparticle-treated genetically engineered cells produced insulin and decreased blood glucose levels in the mice after electromagnetic field application.

Wireless magnetic control of gene expression in mammalian cells has been developed based on intracellular nanointerface and ROS-mediated signalling. The approach allows remotely tunable insulin release and regulates blood glucose in diabetic mice.

New sensor measures strain, strain rate and temperature with single material layer

Researchers from the Institute of Metal Research (IMR) of the Chinese Academy of Sciences have developed an innovative flexible sensor that can simultaneously detect strain, strain rate, and temperature using a single active material layer, representing a significant advance in multimodal sensing technology.

The study, published in Nature Communications, addresses the longstanding challenge of conventional sensors requiring complex multilayer designs that integrate different materials for distinct sensing functions. These traditional approaches often involve complicated signal acquisition and external power supplies, limiting their reliability in continuous monitoring applications.

Led by Prof. Tai Kaiping, the researchers designed the sensor based on a specially designed network of tilted tellurium nanowires (Te-NWs). Through material and structural engineering, they overcame a fundamental limitation where thermoelectric and piezoelectric signals could not be collected in the same direction within conventional materials. In this unique architecture, both signals are simultaneously detected and output in the out-of-plane direction.

Science history: Richard Feynman gives a fun little lecture — and dreams up an entirely new field of physics — Dec. 29, 1959

In a short talk at Caltech, physicist Richard Feynman laid out a vision of manipulating and controlling atoms at the tiniest scale. It would precede the field of nanotechnology by decades.

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