Your brain begins as a single cell. When all is said and done, it will house an incredibly complex and powerful network of some 170 billion cells. How does it organize itself along the way? Cold Spring Harbor Laboratory neuroscientists have come up with a surprisingly simple answer that could have far-reaching implications for biology and artificial intelligence.
Stan Kerstjens, a postdoc in Professor Anthony Zador’s lab, frames the question in terms of positional information. “The only thing a cell ‘sees’ is itself and its neighbors,” he explains. “But its fate depends on where it sits. A cell in the wrong place becomes the wrong thing, and the brain doesn’t develop right. So, every cell must solve two questions: Where am I? And who do I need to become?”
In a study published in Neuron, Kerstjens, Zador, and colleagues at Harvard University and ETH Zürich put forward a new theory for how the brain organizes itself during development.





