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Category: chemistry

New antibiotic for drug-resistant bacteria found hiding in plain sight

Chemists from the University of Warwick and Monash University have discovered a promising new antibiotic that shows activity against drug-resistant bacterial pathogens, including MRSA and VRE.

Antimicrobial resistance (AMR) is one of the world’s most urgent health challenges, with the WHO’s new report showing there are ‘too few antibacterials in the pipeline’. Most of the ‘low-hanging fruit’ has already been found, and the limited commercial incentives deter investment in antibiotic discovery.

In a new study published in the Journal of the American Chemical Society, researchers from the Monash Warwick Alliance Combatting Emerging Superbug Threats Initiative have discovered a promising new antibiotic — pre-methylenomycin C lactone. The newly discovered antibiotic was ‘hiding in plain sight’ – as an intermediate chemical in the natural process that produces the well-known antibiotic methylenomycin A.

Stellar Giants Forged the Chemical Diversity of Ancient Clusters

“Extremely massive stars may have played a key role in the formation of the first galaxies,” said Dr. Paolo Padoan.

How did the extremely massive stars (EMS) in the early universe help form the oldest star clusters? This is what a recent study published in the Monthly Notices of the Royal Astronomical Society hopes to address as an international team of scientists investigated the role that EMS played in not only forming globular clusters (GCs), but how the latter were responsible for forming the first black holes. This study has the potential to help scientists better understand the conditions of the early universe and what this could mean to better understanding our existence.

For the study, the researchers presented a new computational model to help explain how EMS contributed to GC formation with bodies celestial objects being between 1,000 to 10,000 times as massive as our Sun and containing hundreds of thousands to millions of stars, respectively. Given the massive sizes and short lifetimes of EMS, they go supernova when they die, and the new model postulates they become black holes while releasing massive amounts of chemical and hydrogen that mixes with surrounding gas and dust, resulting in the formation of GCs. Additionally, data obtained from NASA’s James Webb Space Telescope (JWST) discovered nitrogen-rich galaxies had chemical signatures obtained from GCs.

This Awesome Periodic Table Shows The Origins of Every Atom in Your Body

Here’s something to think about: the average adult human is made up of-1 (7 octillion) atoms, and most of them are hydrogen — the most common element in the Universe, produced by the Big Bang 13.8 billion years ago.

The rest of those atoms were forged by ancient stars merging and exploding billions of years after the formation of the Universe, and a tiny amount can be attributed to cosmic rays — high-energy radiation that mostly originates from somewhere outside the Solar System.

As astronomer Carl Sagan once said in an episode of Cosmos, “The nitrogen in our DNA, the calcium in our teeth, the iron in our blood, the carbon in our apple pies were made in the interiors of collapsing stars. We are made of starstuff.”

Bisphenol A causes sex-specific changes in metabolism and the immune system, study reveals

Even small amounts of bisphenol A can lead to long-term health effects. When researchers studied adult rats exposed in the fetal stage, they found that females had developed a more masculine and males a more feminine gene expression pattern. This led to females progressing towards a cancer-like state, while males progressed towards metabolic syndrome, which can increase the risk of diabetes and heart disease.

Bisphenol A is a synthetic chemical with estrogen-like properties that is commonly used in food packaging materials. The substance is banned in many products, but is still present in some packaging. Levels of bisphenol A in people’s bodies are often above levels considered safe, with previous research showing that the substance can cause adverse health effects.

Females masculinized and males feminized In the current study, published in Communications Medicine, researchers investigated how bisphenol A affects the body during the fetal stage.

Physicists achieve high precision in measuring strontium atoms using rubidium neighbor

Having good neighbors can be very valuable—even in the atomic world. A team of Amsterdam physicists was able to determine an important property of strontium atoms, a highly useful element for modern applications in atomic clocks and quantum computers, to unprecedented precision. To achieve this, they made clever use of a nearby cloud of rubidium atoms. The results were published in the journal Physical Review Letters this week.

Strontium. It is perhaps not the most popularly known chemical element, but among a group of physicists it has a much better reputation—and rightfully so.

Strontium is one of six so-called alkaline earth metals, meaning that it shares properties with better-known cousins like magnesium, calcium and radium. Strontium atoms have 38 protons in their nucleus, and a varying number of neutrons—for the variations (or isotopes) of strontium that can be found in nature, either 46, 48, 49 or 50.

Protein-based gel restores dental enamel and could advance tooth repair

Scientists from the University of Nottingham’s School of Pharmacy and Department of Chemical and Environmental Engineering, in collaboration with an international team of researchers, have developed a bio-inspired material that has the potential to regenerate demineralized or eroded enamel, strengthen healthy enamel, and prevent future decay. The findings have been published in Nature Communications.

The gel can be rapidly applied to teeth in the same way dentists currently apply standard fluoride treatments. However, this new protein-based gel is fluoride free and works by mimicking key features of the natural proteins that guide the growth of dental enamel in infancy.

When applied, the gel creates a thin and robust layer that impregnates teeth, filling holes and cracks in them. It then functions as a scaffold that takes calcium and phosphate ions from saliva and promotes the controlled growth of new mineral in a process called epitaxial mineralization. This enables the new mineral to be organized and integrated into the underlying natural tissue while recovering both the structure and properties of natural healthy enamel.

CERN’s electrostatic trap ‘recycles’ anions to illuminate the heaviest elements

From the burning of wood to the action of medicines, the properties and behavior of matter are governed by the way chemical elements bond with one another. For many of the 118 known elements, the intricate electronic structures of the atoms that are responsible for chemical bonding are well understood. But for the superheavy elements lying at the far edge of the periodic table, measuring even a single property of these exotic species is a major challenge.

In a new paper published in Nature Communications, a team of researchers working at the ISOLDE facility at CERN report a novel technique that could help unlock the chemistry of (super)heavy elements and has potential applications in fundamental physics research and medical treatments.

Superheavy elements are highly unstable and can only be produced in accelerator laboratories in minute amounts. This is why researchers tend to first perfect their techniques on elements that are stable and lighter.

History of quantum mechanics

The history of quantum mechanics is a fundamental part of the history of modern physics. The major chapters of this history begin with the emergence of quantum ideas to explain individual phenomena—blackbody radiation, the photoelectric effect, solar emission spectra—an era called the Old or Older quantum theories. [ 1 ]

Building on the technology developed in classical mechanics, the invention of wave mechanics by Erwin Schrödinger and expansion by many others triggers the “modern” era beginning around 1925. Paul Dirac’s relativistic quantum theory work led him to explore quantum theories of radiation, culminating in quantum electrodynamics, the first quantum field theory. The history of quantum mechanics continues in the history of quantum field theory. The history of quantum chemistry, theoretical basis of chemical structure, reactivity, and bonding, interlaces with the events discussed in this article.

The phrase “quantum mechanics” was coined (in German, Quantenmechanik) by the group of physicists including Max Born, Werner Heisenberg, and Wolfgang Pauli, at the University of Göttingen in the early 1920s, and was first used in Born and P. Jordan’s September 1925 paper “Zur Quantenmechanik”. [ 2 ] [ 3 ] [ 4 ].

Scientists Unlock the Cancer-Fighting Power of the Rarest Element on Earth

Texas A&M researchers have unlocked a new way to harness astatine-211, a rare and powerful isotope that may revolutionize cancer treatment. Astatine is the rarest naturally occurring element on the planet and among the least explored in the periodic table, largely because its name, derived fr

Experimental proof of long-suspected atomic decay pathway adds new detail to ‘nuclear periodic table’

For the first time, a research team from the University of Cologne has observed the electron capture decay of technetium-98, an isotope of the chemical element technetium (Tc). Electron capture decay is a process in which an atomic nucleus “captures” an electron from its inner shell. The electron merges with a proton in the nucleus to form a neutron, turning the element into a different one. The working group from the Nuclear Chemistry department has thus confirmed a decades-old theoretical assumption.

The findings contribute to a more comprehensive understanding of technetium processes and extend the chart of nuclides—the “nuclear periodic table.” The study was published under the title “Electron-capture decay of 98 Tc” in the journal Physical Review C.

As early as the 1990s, researchers suspected that technetium-98 could also decay by capturing an electron, but no proof could be found, as the isotope only is available in extremely small quantities. For the current study, the Cologne research team used around three grams of technetium-99, which contains tiny traces of the rare isotope technetium-98 (around 0.06 micrograms).

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