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Archive for the ‘life extension’ category

Sep 27, 2020

Epigenetic Clocks: Which Has The Best Correlation For Aging and Age-Related Diseases?

Posted by in categories: biotech/medical, genetics, life extension

11 epigenetic clocks have been published since 2011, but which is best for predicting aging and age-related disease? In this video, I present findings from a recent publication, “Underlying features of epigenetic aging clocks in vitro and in vivo”, that compared data for 11 epigenetic clocks, and derived a new epigenetic clock, the meta-clock.

Sep 26, 2020

Blood Test Analysis: 100 — 111y (Centenarians, Semi- and Super-Centenarians)

Posted by in categories: biotech/medical, life extension

In order to slow aging, it’s important to know how circulating biomarkers change during aging, and how these biomarkers are associated with risk of death for all causes. In this video, I discuss blood test data for the oldest old, including centenarians (100 — 104y), semi-centenarians (105 — 109y), and super-centenarians (110y+).

Sep 26, 2020

Humans live much longer than chimps due to a slower epigenetic ‘clock’

Posted by in categories: biotech/medical, chemistry, genetics, life extension

Lil bits of info on DNA methylation, clocks.


Breakthrough advances in medicine and better nutrition have dramatically improved the longevity of the average human over the past two centuries. But that’s not to say that some couldn’t go on to live a long life even before the advent of modern medicine. As long as they were spared by disease, wars, and other risks that can bring an untimely death, humans could live to see their 70s, 80s, and even reach 100 years old as far back as ancient Rome.

The longevity of humans is somewhat exceptional among primates. Chimpanzees, our closest living relatives, rarely make it past age 50, despite them sharing over 99% of our DNA. In a new study, researchers think they’ve found our secret: chemical changes along our genome that occurred around 7–8 million years ago when our ancestors branched away from the lineage of chimps.

Continue reading “Humans live much longer than chimps due to a slower epigenetic ‘clock’” »

Sep 24, 2020

Diabetes Drug Metformin May Protect Aging Brains

Posted by in categories: biotech/medical, life extension, neuroscience

WEDNESDAY, Sept. 23, 2020 (HealthDay News) — A common type 2 diabetes drug called metformin may have an unexpected, but positive, side effect: New research suggests that people taking the drug appear to have significantly slower declines in thinking and memory as they age.

“Our six-year study of older Australians with type 2 diabetes has uncovered a link between metformin use and slower cognitive [mental] decline and lower dementia rates,” said study author Dr. Katherine Samaras. She’s the leader of the healthy aging research theme at the Garvan Institute of Medical Research in New South Wales, Australia.

“The findings provide new hope for a means of reducing the risk of dementia in individuals with type 2 diabetes, and potentially those without diabetes,” Samaras said.

Continue reading “Diabetes Drug Metformin May Protect Aging Brains” »

Sep 23, 2020

Targeting the Mechanisms of Aging Across Species

Posted by in categories: biotech/medical, life extension, neuroscience, transhumanism

Targeting Mechanisms of Aging Across Species — I am joined on this episode of ideaXme by Dr. Matt Kaeberlein, Professor of Pathology, Adjunct Professor of Genome Sciences, and Adjunct Professor of Oral Health Sciences, University of Washington, to discuss his research focus on cross-species mechanisms of aging, in order to facilitate interventions that extend healthspan and improve quality of life — #Ideaxme #Health #Wellness #Longevity #Aging #LifeExtension #Rapamycin #MTor #CElegans #ExtracellularVesicles #Geroscience #GenomicInstability #AlzheimersDisease #Neurodegeneration #Parkinsons #MitochondrialDysfunction #OralHealth #SystemsBiology #DogAgingProject #Science #Transhumanism #Innovation #Immortality #IraPastor #Bioquark #Regenerage The Dog Aging Project.


Ira Pastor, idea me life sciences ambassador and founder of Bioquark, interviews Dr. Matt Kaeberlein, Professor of Pathology, Adjunct Professor of Genome Sciences, and Adjunct Professor of Oral Health Sciences at the University of Washington.

Continue reading “Targeting the Mechanisms of Aging Across Species” »

Sep 23, 2020

Boxer George “Monk” Foreman III talks of Compassion and Everybody Fights!

Posted by in categories: business, life extension

Boxing, Business, and Well-Being — I am joined on this episode of ideaXme by George Foreman III; entrepreneur, professional boxer, trainer, coach, son / business partner of former two-time heavyweight boxing champion George Foreman, and founder of EverybodyFights, a rapidly expanding chain of high-end, state-of-the-art boxing and fitness gyms — #Ideaxme #Health #Wellness #Boxing #GeorgeForeman #Fitness #Gyms #Nutrition #Longevity #Aging #Healthspan #Lifespan #LifeExtension #Business #Entrepreneurship #Innovation #Startup #IraPastor #Bioquark #Regenerage


Ira Pastor, ideaXme life sciences ambassador, interviews George “Monk” Foreman III; entrepreneur, professional boxer, trainer, coach, and Founder of Everybody Fights.

Continue reading “Boxer George ‘Monk’ Foreman III talks of Compassion and Everybody Fights!” »

Sep 23, 2020

Is Aging a Disease You Can Reverse? A Look at the Science Behind the Longevity Movement

Posted by in categories: biotech/medical, life extension, science

We all want to know how to live longer, but is a prolonged life a healthy, happy one? One Vogue writer looks at the science that says it might be possible.

Sep 23, 2020

David Sinclair talks about human rejuvenation (Excerpt with S/T in Spanish)

Posted by in categories: biotech/medical, life extension

Short excerpt of a recent interview with Dr. David Sinclair published in the Youtube channel “Think Inc.”


Short excerpt of an interview with Dr. David Sinclair published in the Youtube channel “Think Inc.“
During the interview, Dr. Sinclair referres to the possibility of turning back the biological aging clock of the entire human body, through partial cellular reprograming in the not so distant future.

Continue reading “David Sinclair talks about human rejuvenation (Excerpt with S/T in Spanish)” »

Sep 20, 2020

Aubrey de Grey’s Prediction for 2020

Posted by in category: life extension

Aubrey de Grey, Chairman and Chief Science Officer of the Methuselah Foundation, presents a realistic scenario for 2020 in which everyone knows we will defeat the aging process.

Sep 15, 2020

Dr. Brian Kennedy — Preventive Medicine in an Aging Society

Posted by in categories: biotech/medical, life extension

At our first online conference, Ending Age-Related Diseases 2020, Dr. Brian Kennedy of the National University of Singapore discussed the aging population of Singapore, the need for comprehensive healthcare, alpha-ketoglutarate and its effects against frailty in mice, ongoing trials of ketoglutarate in humans, spermidine against obesity, the role of biomarkers, and the importance of keeping people well rather than simply treating them when they are sick.

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