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Mindscape 242 | David Krakauer on Complexity, Agency, and Information

Patreon: https://www.patreon.com/seanmcarroll.
Blog post with audio player, show notes, and transcript: https://www.preposterousuniverse.com/podcast/2023/07/10/242-…formation/

Complexity scientists have been able to make an impressive amount of progress despite the fact that there is not universal agreement about what “complexity” actually is. We know it when we see it, perhaps, but there are a number of aspects to the phenomenon, and different researchers will naturally focus on their favorites. Today’s guest, David Krakauer, is president of the Santa Fe Institute and a longtime researcher in complexity. He points the finger at the concept of agency. A ball rolling down a hill just mindlessly obeys equations of motion, but a complex system gathers information and uses it to adapt. We talk about what that means and how to think about the current state of complexity science.

David Krakauer received his D.Phil. in evolutionary biology from Oxford University. He is currently President and William H. Miller Professor of Complex Systems at the Santa Fe Institute. Previously he was at the University of Wisconsin, Madison, where he was the founding director of the Wisconsin Institute for Discovery and the Co-director of the Center for Complexity and Collective Computation. He was included in Wired magazine’s list of “50 People Who Will Change the World.”

Mindscape Podcast playlist: https://www.youtube.com/playlist?list=PLrxfgDEc2NxY_fRExpDXr87tzRbPCaA5x.
Sean Carroll channel: https://www.youtube.com/c/seancarroll.

#podcast #ideas #science #philosophy #culture

Association of blood-based DNA methylation of lncRNAs with Alzheimer’s disease diagnosis

DNA methylation has shown great potential in Alzheimer’s disease (AD) blood diagnosis. However, the ability of long non-coding RNAs (lncRNAs), which can be modified by DNA methylation, to serve as noninvasive biomarkers for AD diagnosis remains unclear.

We performed logistic regression analysis of DNA methylation data from the blood of patients with AD compared and normal controls to identify epigenetically regulated (ER) lncRNAs. Through five machine learning algorithms, we prioritized ER lncRNAs associated with AD diagnosis. An AD blood diagnosis model was constructed based on lncRNA methylation in Australian Imaging, Biomarkers, and Lifestyle (AIBL) subject and verified in two large blood-based studies, the European collaboration for the discovery of novel biomarkers for Alzheimer’s disease (AddNeuroMed) and the Alzheimer’s Disease Neuroimaging Initiative (ADNI). In addition, the potential biological functions and clinical associations of lncRNAs were explored, and their neuropathological roles in AD brain tissue were estimated via cross-tissue analysis.

We characterized the ER lncRNA landscape in AD blood, which is strongly related to AD occurrence and process. Fifteen ER lncRNAs were prioritized to construct an AD blood diagnostic and nomogram model. The receiver operating characteristic (ROC) curve and the decision and calibration curves show that the model has good prediction performance. We found that the targets and lncRNAs were correlated with AD clinical features. Moreover, cross-tissue analysis revealed that the lncRNA ENSG0000029584 plays both diagnostic and neuropathological roles in AD.

BrainBody-LLM algorithm helps robots mimic human-like planning and movement

Large language models (LLMs), such as the model underpinning the functioning of OpenAI’s platform ChatGPT, are now widely used to tackle a wide range of tasks, ranging from sourcing information to the generation of texts in different languages and even code. Many scientists and engineers also started using these models to conduct research or advance other technologies.

In the context of robotics, LLMs have been found to be promising for the creation of robot policies derived from a user’s instructions. Policies are essentially “rules” that a robot needs to follow to correctly perform desired actions.

Researchers at NYU Tandon School of Engineering recently introduced a new algorithm called BrainBody-LLM, which leverages LLMs to plan and refine the execution of a robot’s actions. The new algorithm, presented in a paper published in Advanced Robotics Research, draws inspiration from how the human brain plans actions and fine-tunes the body’s movements over time.

Laude × CSGE: Bill Joy — 50 Years of Advancements: Computing and Technology 1975–2025 (and beyond)

From the rise of numerical and symbolic computing to the future of AI, this talk traces five decades of breakthroughs and the challenges ahead.

Bill is the author of Berkeley UNIX, cofounder of Sun Microsystems, author of “Why the Future Doesn’t Need Us” (Wired 2000), ex-cleantech VC at Kleiner Perkins, investor in and unpaid advisor to Nodra. AI.

Talk Details.
50 Years of Advancements: Computing and Technology 1975–2025 (and beyond)

I came to UC Berkeley CS in 1975 as a graduate student expecting to do computer theory— Berkeley CS didn’t have a proper departmental computer, and I was tired of coding, having written a lot of numerical code for early supercomputers.

But it’s hard to make predictions, especially about the future. Berkeley soon had a Vax superminicomputer, I installed a port of UNIX and was upgrading the operating system, and the Internet and Microprocessor boom beckoned.

Continue reading “Laude × CSGE: Bill Joy — 50 Years of Advancements: Computing and Technology 1975–2025 (and beyond)” | >

Diamond quantum sensors improve spatial resolution of MRI

This accomplishment breaks the previous record of 48 qubits set by Jülich scientists in 2019 on Japan’s K computer. The new result highlights the extraordinary capabilities of JUPITER and provides a powerful testbed for exploring and validating quantum algorithms.

Simulating quantum computers is essential for advancing future quantum technologies. These simulations let researchers check experimental findings and experiment with new algorithmic approaches long before quantum hardware becomes advanced enough to run them directly. Key examples include the Variational Quantum Eigensolver (VQE), which can analyze molecules and materials, and the Quantum Approximate Optimization Algorithm (QAOA), used to improve decision-making in fields such as logistics, finance, and artificial intelligence.

Recreating a quantum computer on conventional systems is extremely demanding. As the number of qubits grows, the number of possible quantum states rises at an exponential rate. Each added qubit doubles the amount of computing power and memory required.

Although a typical laptop can still simulate around 30 qubits, reaching 50 qubits requires about 2 petabytes of memory, which is roughly two million gigabytes. ‘Only the world’s largest supercomputers currently offer that much,’ says Prof. Kristel Michielsen, Director at the Jülich Supercomputing Centre. ‘This use case illustrates how closely progress in high-performance computing and quantum research are intertwined today.’

The simulation replicates the intricate quantum physics of a real processor in full detail. Every operation – such as applying a quantum gate – affects more than 2 quadrillion complex numerical values, a ‘2’ with 15 zeros. These values must be synchronized across thousands of computing nodes in order to precisely replicate the functioning of a real quantum processor.

The JUPITER supercomputer set a new milestone by simulating 50 qubits. New memory and compression innovations made this breakthrough possible. A team from the Jülich Supercomputing Centre, working with NVIDIA specialists, has achieved a major milestone in quantum research. For the first time, they successfully simulated a universal quantum computer with 50 qubits, using JUPITER, Europe’s first exascale supercomputer, which began operation at Forschungszentrum Jülich in September.

Continue reading “Diamond quantum sensors improve spatial resolution of MRI” | >

Rules that Reality Plays By — Dr. Stephen Wolfram, DemystifySci #343

Stephen Wolfram is a physicist, mathematician, and programmer who believes he has discovered the computational rules that organize the universe at the finest grain. These rules are not physical rules like the equations of state or Maxwell’s equations. According to Wolfram, these are rules that govern how the universe evolves and operates at a level at least one step down below the reality that we inhabit. His computational principles are inspired by the results observed in cellular automata systems, which show that it’s possible to take a very simple system, with very simple rules, and end up at complex patterns that often look organic and always look far more intricate than the black and white squares that the game started with. He believes that the hyperspace relationships that emerge when he applies a computational rule over and over again represent the nature of the universe — and that the relationships that emerge contain everything from the seed of human experience to the equations for relativity, evolution, and black holes. We sit down with him for a conversation about the platonic endeavor that he has undertaken, where to draw the line between lived experience and the computational universe, the limits of physics, and the value of purpose and the source of consciousness.

MAKE HISTORY WITH US THIS SUMMER:
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PATREON
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PARADIGM DRIFT
https://demystifysci.com/paradigm-drift-show.

Material solutions to quantum spookiness: https://www.youtube.com/@MaterialAtomics.

00:00 Go!

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A new artificial muscle could let humanoid robots lift 4,400 times their weight

A new material bends that rule.

Researchers in South Korea say they have built a soft, magnetic artificial muscle that hits hard numbers without turning into a stiff piston. The material flexes, contracts and relaxes like flesh, yet ramps up stiffness on demand when asked to do real work. That mix has long sat out of reach for humanoid robots that need both agility and strength.

Most humanoids move with a cocktail of motors, gears and pneumatic lines. These systems deliver power, but they also add bulk and make contact risky. Soft actuators change the equation. They integrate into limbs, cushion impacts and tolerate misalignment. They also weigh far less than hydraulic stacks and slot neatly inside compact forms like hands, faces and torsos.

Biochemistry: Glucose Metabolism Overview Part II

GLUCOSE OXIDATION EQUATION Glucose + 6 O2 — 6 CO2 + 6 H2O + Energy (ATP + heat) • Most energy is generated in mitochondrial matrixCommon Abbreviations: • ATP: adenosine triphosphate • NADH: nicotinamide adenine dinucleotide • FADH2: flavin adenine dinucleotide • CoA: Coenzyme AKEY PROCESSES IN GLUCOSE OXIDATION • Glycolysis • Pyruvate decarboxylation • Citric acid cycle (also known as the Krebs’ cycle and the tri-carboxylic acid (TCA) cycle) • Oxidative phosphorylation (electron transport chain & chemiosmosis)CITRIC ACID CYCLE • 1 glucose molecule requires 2 citric acid cycle turns • Input for each turn: 1 Acetyl CoA • Output for each turn: 3 NADH + 2 CO2 + 1 ATP + 1 FADH2 • NADH & FADH2: electron transfer molecules for oxidative phosphorylation • Occurs in mitochondrial matrixSubstrate level phosphorylation • ATP generated from substrates in glycolysis and citric acid cycle • NOT from.

We’re (Probably) Not Alone Out Here… — YouTube

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Why haven’t we heard from aliens? That’s a question that sounds simple but turns into a mess the moment you try to answer it. Recently, a mathematician tried to simplify the equation by trying to calculate the odds that we’re the only intelligent life in the universe – according to his math, we shouldn’t be. Let’s take a look.

Paper: https://www.sciencedirect.com/science… Check out my new quiz app ➜ http://quizwithit.com/ 📚 Buy my book ➜ https://amzn.to/3HSAWJW 💌 Support me on Donorbox ➜ https://donorbox.org/swtg 📝 Transcripts and written news on Substack ➜ https://sciencewtg.substack.com/ 👉 Transcript with links to references on Patreon ➜ / sabine 📩 Free weekly science newsletter ➜ https://sabinehossenfelder.com/newsle… 👂 Audio only podcast ➜ https://open.spotify.com/show/0MkNfXl… 🔗 Join this channel to get access to perks ➜ / @sabinehossenfelder #science #sciencenews #aliens #maths.

🤓 Check out my new quiz app ➜ http://quizwithit.com/
📚 Buy my book ➜ https://amzn.to/3HSAWJW
💌 Support me on Donorbox ➜ https://donorbox.org/swtg.
📝 Transcripts and written news on Substack ➜ https://sciencewtg.substack.com/
👉 Transcript with links to references on Patreon ➜ / sabine.
📩 Free weekly science newsletter ➜ https://sabinehossenfelder.com/newsle…
👂 Audio only podcast ➜ https://open.spotify.com/show/0MkNfXl…
🔗 Join this channel to get access to perks ➜
/ @sabinehossenfelder.

#science #sciencenews #aliens #maths

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