Queen ants live far longer than genetically identical workers. Researchers are learning what their longevity secrets could mean for aging in other species.
Dr Vittorio Sebastiano presents about aging and reprogramming and answers questions from audience in this clip. He specifies short Reprogramming does not impact cellular Identity but Impact cellular age and cellular health.
Dr. Vittorio Sebastiano is an Assistant Professor in the Department of Obstetrics and Gynecology at Stanford School of Medicine. His lab has established a new technology named ERA (Epigenetic Reprogramming of Aging), which repurposes the conceptual idea of reprogramming, with the goal to promote epigenetic rejuvenation of adult cells leaving their identity untouched. This new technology was patented and is being implemented by Turn Biotechnologies, of which Dr. Sebastiano is co-founder and Chair of the Scientific Advisory Board.
Some health conditions associated with appeared early and consistently long before diagnosis, while others became significant much later, a cohort study suggested.
For people with a subsequent diagnosis of Alzheimerโs disease, the earliest and most consistent associations at all time points over a 15-year span included depression, erectile dysfunction, gait abnormalities, hearing loss, and nervous and musculoskeletal symptoms, reported Lori Beason-Held, PhD, of the National Institute on Aging in Baltimore, and co-authors.
For those eventually diagnosed with vascular, the earliest and most consistent associations across 13 years were an abnormal electrocardiogram (EKG), cardiac dysrhythmias, cerebrovascular disease, non-epithelial skin cancer, depression, and hearing loss, the researchers reported in Annals of Neurology.
Dr. Aubrey de Grey is a legend in the longevity field who has been steadfastly promoting the idea of life extension since well before it became mainstream. While with SENS Research Foundation, de Grey made significant contributions to geroscience, and at Longevity Summit Dublin last year, he announced the creation of his new brainchild, Longevity Escape Velocity Foundation (LEVF).
Now, the first major and long-awaited LEVF-funded project is being launched: Robust Mouse Rejuvenation (RMR). This is envisioned as a rolling research program aiming to increase both the mean and maximum lifespan of mice by at least 12 months with various combination therapies started late in life. For the first study, four therapies have been chosen: rapamycin, a senolytic, hematopoietic stem cell transplantation (HSCT), and telomerase expression. A groundbreaking experiment by any measure, RMR got us excited, and we reached out to Aubrey to discuss both RMR and LEVF in depth.
The following interview has Arkadi asking questions in bold and Aubrey de Grey answering in normal font.
Time to reverse your age and restore youth.
Scientists at a San Diego-based biotech company Rejuvenate Bio claim to have increased the age of mice by reprogramming their genes. They believe their gene therapy actually works like a reverse aging technique that one day might be used for rejuvenating humans.
Continue reading “Scientists reprogrammed miceโs genes to live longer, and it worked!” »
๐๐ซ๐๐ข๐ง ๐๐ซ๐๐ ๐๐๐๐๐ฌ๐ฌ๐๐ซ๐ฒ ๐๐จ๐ซ ๐ ๐ฅ๐ฎ๐ข๐ ๐๐ง๐ญ๐๐ฅ๐ฅ๐ข๐ ๐๐ง๐๐ ๐๐๐๐ง๐ญ๐ข๐๐ข๐๐ โ ๐๐๐๐ข๐ง๐ข๐ง๐ ๐ ๐๐๐ญ๐ฎ๐ซ๐ ๐จ๐ ๐๐ฎ๐ฆ๐๐ง ๐๐จ๐ ๐ง๐ข๐ญ๐ข๐จ๐ง
๐ผ ๐ฉ๐๐๐ข ๐ก๐๐ ๐๐ฎ ๐๐ฃ๐๐ซ๐๐ง๐จ๐๐ฉ๐ฎ ๐พ๐ค๐ก๐ก๐๐๐ ๐๐ค๐ฃ๐๐ค๐ฃ (๐๐พ๐) ๐๐ฃ๐ ๐๐ฃ๐๐ซ๐๐ง๐จ๐๐ฉ๐ฎ ๐พ๐ค๐ก๐ก๐๐๐ ๐๐ค๐ฃ๐๐ค๐ฃ ๐๐ค๐จ๐ฅ๐๐ฉ๐๐ก๐จ (๐๐พ๐๐) ๐ง๐๐จ๐๐๐ง๐๐๐๐ง๐จ ๐๐๐จ ๐ข๐๐ฅ๐ฅ๐๐ ๐ฉ๐๐ ๐ฅ๐๐ง๐ฉ๐จ ๐ค๐ ๐ฉ๐๐ ๐๐ง๐๐๐ฃ ๐ฉ๐๐๐ฉ ๐จ๐ช๐ฅ๐ฅ๐ค๐ง๐ฉ ๐ค๐ช๐ง ๐๐๐๐ก๐๐ฉ๐ฎ ๐ฉ๐ค ๐จ๐ค๐ก๐ซ๐ ๐ฅ๐ง๐ค๐๐ก๐๐ข๐จ ๐ฌ๐๐ฉ๐๐ค๐ช๐ฉ ๐ฅ๐ง๐๐ค๐ง ๐๐ญ๐ฅ๐๐ง๐๐๐ฃ๐๐ โ ๐ค๐ฉ๐๐๐ง๐ฌ๐๐จ๐ ๐ ๐ฃ๐ค๐ฌ๐ฃ ๐๐จ ๐๐ก๐ช๐๐ ๐๐ฃ๐ฉ๐๐ก๐ก๐๐๐๐ฃ๐๐. ๐๐ก๐ช๐๐ ๐๐ฃ๐ฉ๐๐ก๐ก๐๐๐๐ฃ๐๐ ๐๐จ ๐๐ง๐๐ช๐๐๐ก๐ฎ ๐ฉ๐๐ ๐๐๐๐๐ฃ๐๐ฃ๐ ๐๐๐๐ฉ๐ช๐ง๐ ๐ค๐ ๐๐ช๐ข๐๐ฃ ๐๐ค๐๐ฃ๐๐ฉ๐๐ค๐ฃ. ๐๐ฉ ๐ฅ๐ง๐๐๐๐๐ฉ๐จ ๐๐๐ช๐๐๐ฉ๐๐ค๐ฃ๐๐ก ๐๐ฃ๐ ๐ฅ๐ง๐ค๐๐๐จ๐จ๐๐ค๐ฃ๐๐ก ๐จ๐ช๐๐๐๐จ๐จ, ๐จ๐ค๐๐๐๐ก ๐ข๐ค๐๐๐ก๐๐ฉ๐ฎ, ๐๐๐๐ก๐ฉ๐, ๐๐ฃ๐ ๐ก๐ค๐ฃ๐๐๐ซ๐๐ฉ๐ฎ. ๐๐ฉ ๐๐ก๐จ๐ค ๐๐ค๐ง๐ง๐๐ก๐๐ฉ๐๐จ ๐ฌ๐๐ฉ๐ ๐ข๐๐ฃ๐ฎ ๐๐ค๐๐ฃ๐๐ฉ๐๐ซ๐ ๐๐๐๐ก๐๐ฉ๐๐๐จ ๐จ๐ช๐๐ ๐๐จ ๐ข๐๐ข๐ค๐ง๐ฎ.
A team led by University College London (UCL) and University College London Hospitals (UCLH) researchers has mapped the parts of the brain that support our ability to solve problems without prior experience โ otherwise known as fluid intelligence.
Nearly half of people worldwide do not get the recommended daily total water intake, a new report indicates.
Yet drinking enough water may help to delay the aging process for many.
A recent study by the National Institutes of Health (NIH) published in eBioMedicine suggests as much โ though there are caveats to know.
A team of researchers affiliated with multiple institutions in Canada has found that obesity in young mice can lead to inflammatory disease later in life even if the mouse is no longer overweight. In their paper published in the journal Science, the group describes studying early life obesity in test mice and the development of age-related macular degeneration. Kevin Mangum and Katherine Gallagher with the University of Michigan have published a Perspectives piece in the same journal issue outlining the research.
Age-related macular degeneration (AMD) in older people can lead to permanent blindness. Prior research has shown obesity plays a major role in its development. Other research has also shown that AMD is a neuroinflammatory condition. It is believed that the inflammation in the eyes is related to obesity, but the exact connection has not been identified. In this new effort, the researchers sought to find the connection by studying obesity and macular degeneration in mice.
The work involved feeding test mice a high-fat diet and studying the impact on adipose tissue macrophages (types of white blood cells that are part of the immune system). They found that obesity in mice led to epigenetic changes in the macrophages that resulted in an increase in expression of genes that incite an inflammatory response. They also found that the increased expression continued even after the test mice were put on a reduced diet that allowed them to return to their normal weight.
The transport of mercury ions across intestinal epithelial cells can be studied for toxicology assessments by using animal models and static cell cultures. However, the concepts do not reliably replicate conditions of the human gut microenvironment to monitor in situ cell physiology. As a result, the mechanism of mercury transport in the human intestine is still unknown.
In a new report now published in Nature Microsystems and Nanoengineering, Li Wang and a research team in mechanical engineering and regenerative medicine in China developed a gut-on-a-chip instrument integrated with transepithelial electrical resistance (TEER) sensors and electrochemical sensors.
They proposed to explore the dynamic concept to simulate the physical intestinal barrier and mirror biological transport and adsorption mechanisms of mercury ions. The scientists recreated the cellular microenvironment by applying fluid shear stress and cyclic mechanical strain.
