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Category: wearables

Shapeshifting materials could power next generation of soft robots

McGill University engineers have developed new ultra-thin materials that can be programmed to move, fold and reshape themselves, much like animated origami. They open the door to softer, safer and more adaptable robots that could be used in medical tools that gently move inside the body, wearable devices that change shape on the skin or smart packaging that reacts to its environment.

The research, jointly led by the laboratories of Hamid Akbarzadeh in the Department of Bioresource Engineering and Marta Cerruti in the Department of Mining and Material Engineering, shows how simple, paper-like sheets made from folded graphene oxide (GO) can be turned into tiny devices that walk, twist, flip and sense their own motion. Two related studies demonstrate how these materials can be made at scale, programmed to change shape and controlled either by humidity or magnetic fields.

The studies are published in Materials Horizons and Advanced Science.

AI model detects prediabetes using ECG data without need for blood tests

DiaCardia, a novel artificial intelligence model that can accurately identify individuals with prediabetes using either 12-lead or single-lead electrocardiogram (ECG) data, has been developed. This breakthrough holds promise for future home-based prediabetes screening using consumer wearable devices, without requiring invasive blood tests.

Type 2 diabetes occurs when the human body either cannot make enough insulin or does not use insulin well, resulting in high blood glucose levels. This condition is a growing global health burden that can reduce the quality of life and life expectancy.

Before type 2 diabetes develops, many people go through a prolonged stage called prediabetes, where blood glucose levels are above normal but not high enough to be diagnosed as diabetes. Prediabetes is an important window wherein lifestyle changes can reduce the progression to diabetes.

Soft, 3D transistors could host living cells for bioelectronics

New research from the WISE group (Wearable, Intelligent, Soft Electronics) at The University of Hong Kong (HKU-WISE) has addressed a long-standing bioelectronic challenge: the development of soft, 3D transistors.

This work introduces a new approach to semiconductor device design with transformative potential for bioelectronics. It is published in Science.

Led by Professor Shiming Zhang from the Department of Electrical and Electronic Engineering, Faculty of Engineering, the research team included senior researchers who joined HKU-WISE from the University of Cambridge and the University of Chicago, together with HKU Ph.D. students and undergraduate participants—an international, inclusive, and dynamic research community.

Shrinking materials hold big potential for smart devices, researchers say

Wearable electronics could be more wearable, according to a research team at Penn State. The researchers have developed a scalable, versatile approach to designing and fabricating wireless, internet-enabled electronic systems that can better adapt to 3D surfaces, like the human body or common household items, paving the path for more precise health monitoring or household automation, such as a smart recliner that can monitor and correct poor sitting habits to improve circulation and prevent long-term problems.

The method, detailed in Science Advances, involves printing liquid metal patterns onto heat-shrinkable polymer substrates—otherwise known as the common childhood craft “Shrinky Dinks.” According to team lead Huanyu “Larry” Cheng, James L. Henderson, Jr. Memorial Associate Professor of Engineering Science and Mechanics in the College of Engineering, the potentially low-cost way to create customizable, shape-conforming electronics that can connect to the internet could make the broad applications of such devices more accessible.

“We see significant potential for this approach in biomedical uses or wearable technologies,” Cheng said, noting that the field is projected to reach $186.14 billion by 2030. “However, one significant barrier for the sector is finding a way to manufacture an easy-to-customize device that can be applied to freestanding, freeform surfaces and communicate wirelessly. Our method solves that.”

Harnessing Wearable Tech in Gastrointestinal Care

Wearable technologies have the potential to transform gastrointestinal care by enabling continuous monitoring of activity in patients with cirrhosis and aiding in the early detection of hepatic encephalopathy. While these innovations provide valuable clinical insights, further efforts are needed to address challenges related to implementation and data management.

Current research into wearable technology in liver disease supports these possibilities. Studies of wrist-worn activity monitors have shown that reduced activity is associated with increased waitlist mortality among liver transplant candidates, as well as increased hospital admissions and mortality in patients with cirrhosis. Other investigations with wearables have linked sleep disturbances to poorer post-liver transplant outcomes and explored skin patches and transdermal sensors for detecting blood alcohol levels and inflammatory markers predictive of outcomes in cirrhosis, Buckholz said.

A major barrier to widespread implementation in clinical practices is the so-called “wearable paradox,” whereby early adopters of wearable technology tend to be relatively healthy, whereas those at highest risk are less likely to already use such devices, Buckholz noted. Increasing access, understanding, and uptake in vulnerable populations will therefore be critical.

Additional challenges include determining how to distill massive volumes of wearable data into concise formats that can be incorporated into electronic medical records (EMRs) and easily communicated to patients.

Developmental Cell

Cancer stem cell plasticity and tumor hierarchy👇

✅Hierarchical tumor organization Tumors are organized in a hierarchical manner, with cancer stem cells (CSCs) positioned at the apex. CSCs possess long-term self-renewal capacity and generate diverse progeny, sustaining tumor growth and cellular heterogeneity.

✅Self-renewal and differentiation CSCs can undergo self-renewal to maintain the stem cell pool or differentiate into multiple cancer cell lineages. These differentiated cells form the bulk of the tumor and display varying functional and phenotypic states.

✅Cell plasticity and dedifferentiation Differentiated cancer cells are not irreversibly committed. Through cellular plasticity, they can dedifferentiate back into CSCs, often via processes such as epithelial–mesenchymal transition (EMT), restoring stem-like properties.

✅Interconversion of CSC states Distinct CSC subpopulations can transition between different stemness states. This dynamic interconversion enhances tumor adaptability and contributes to therapy resistance and disease progression.

✅Biological and clinical relevance The combination of hierarchy and plasticity allows tumors to regenerate after treatment and maintain intratumoral diversity. Targeting both CSCs and the mechanisms that enable plasticity is therefore critical for effective cancer therapy.

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