Caps on the ends of chromosomes are critical for maintaining genetic integrity and promoting healthy aging.
The convergence of Biotechnology, Neurotechnology, and Artificial Intelligence has major implications for the future of humanity. This talk explores the long-term opportunities inherent to these fields by surveying emerging breakthroughs and their potential applications. Whether we can enjoy the benefits of these technologies depends on us: Can we overcome the institutional challenges that are slowing down progress without exacerbating civilizational risks that come along with powerful technological progress?
About the speaker: Allison Duettmann is the president and CEO of Foresight Institute. She directs the Intelligent Cooperation, Molecular Machines, Biotech & Health Extension, Neurotech, and Space Programs, Fellowships, Prizes, and Tech Trees, and shares this work with the public. She founded Existentialhope.com, co-edited Superintelligence: Coordination & Strategy, co-authored Gaming the Future, and co-initiated The Longevity Prize. She advises companies and projects, such as Cosmica, and The Roots of Progress Fellowship, and is on the Executive Committee of the Biomarker Consortium. She holds an MS in Philosophy & Public Policy from the London School of Economics, focusing on AI Safety.
A new study is finding that greener neighborhoods protect telomeres which prevent aging on a genetic level.
The role of telomeres in aging
Telomeres are repetitive sequences of DNA found at the ends of chromosomes that play a crucial role in preserving the integrity and stability of the genetic material within a cell.
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Research led by Peking University, China, has discovered a single type of retinal photoreceptor cell in Drosophila (fruit fly) is involved in both visual perception and circadian photoentrainment by co-releasing histamine and acetylcholine at the first visual synapse.
In a paper, “A single photoreceptor splits perception and entrainment by cotransmission,” published in Nature, the team details the discovery that the Drosophila visual system segregates visual perception and circadian photoentrainment by co-transmitting two neurotransmitters, histamine and acetylcholine, in the R8 photoreceptor cells.
Light detection involves capturing signals through photoreceptors in the eye, which are essential for image formation and subconscious visual functions, such as regulating biological rhythms according to the daily light-dark cycle (photoentrainment of the circadian clock). The optical system has distinct pathways for image formation (based on local contrast) and non-image-related tasks (based on global irradiance).
The naked mole rat won’t win any beauty contests, but it could possibly win in the talent category. Its superpower: fighting the aging process to live several times longer than other animals its size, in a state of youthful vigor.
It’s believed that naked mole rats experience all the normal processes of wear and tear over their lifespan, but that they’re exceptionally good at repairing the damage from oxygen free radicals and the DNA errors that accumulate over time. Even though they possess genes that make them vulnerable to cancer, they rarely develop the disease, or any other age-related disease, for that matter. Naked mole rats are known to live for over 40 years without any signs of aging, whereas mice live on average about two years and are highly prone to cancer.
Now, these remarkable animals may be able to share their superpower with other species. In August, a study provided what may be the first proof-of-principle that genetic material transferred from one species can increase both longevity and healthspan in a recipient animal.
Regenerative medicine and tissue engineering strategies have made remarkable progress in remodeling, replacing, and regenerating damaged cardiovascular tissues. The design of three-dimensional (3D) scaffolds with appropriate biochemical and mechanical characteristics is critical for engineering tissue-engineered replacements. The extracellular matrix (ECM) is a dynamic scaffolding structure characterized by tissue-specific biochemical, biophysical, and mechanical properties that modulates cellular behavior and activates highly regulated signaling pathways. In light of technological advancements, biomaterial-based scaffolds have been developed that better mimic physiological ECM properties, provide signaling cues that modulate cellular behavior, and form functional tissues and organs.
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Ultra-processed foods can have a negative effect on mental health, and this is especially true for younger people, who consume more of these foods than older people.
Over time, there has been increasing evidence that those whose diet includes large quantities of ultra-processed foods are more likely to develop physical health issues.
These issues can include obesity, type 2 diabetes, cardiovascular disease, and even more rapid aging. This is supported by wide research, including a paper by the IRCCS Neuromed Mediterranean Neurological Institute in Italy, involving about 23,000 citizens from the Molise region.
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Continue reading “23 Younger Biological Age: Supplements, Diet (Blood Test #6 in 2023)” »
