Lifeboat Foundation

NewLimit, a company working towards the radical extension of human healthspan using epigenetic reprogramming has announced it has secured $40 million in Series A funding from prominent investors including Dimension, Founders Fund, and Kleiner Perkins.

This investment further bolsters the company’s belief that therapies to delay, halt or even reverse aging can be found through the exploration of epigenetic reprogramming. With a strong belief that their innovative approach can also address various age-related diseases, NewLimit aims to revolutionize the field of aging biology and pave the way for transformative advancements in healthcare.

Longevity. Technology: Epigenetic reprogramming is an emerging but exciting field of geroscience. It involves the identification of specific sets of transcription factors that can induce changes in gene expression and cellular behavior, effectively reversing or modifying the epigenetic markers associated with aging. This approach offers a unique opportunity to rejuvenate cells and tissues, potentially slowing down or even reversing the effects of aging and its related diseases. NewLimit says that while its products are designed to treat aging itself, the company also believes “these products could treat or prevent many diseases associated with aging, including fibrosis, infectious disease, and neurodegenerative disease.”

A new publication in the May issue of Nature Aging by researchers from Integrated Biosciences, a biotechnology company combining synthetic biology and machine learning to target aging, demonstrates the power of artificial intelligence (AI) to discover novel senolytic compounds, a class of small molecules under intense study for their ability to suppress age-related processes such as fibrosis, inflammation and cancer.

The paper, “Discovering small-molecule senolytics with deep neural networks,” authored in collaboration with researchers from the Massachusetts Institute of Technology (MIT) and the Broad Institute of MIT and Harvard, describes the AI-guided screening of more than 800,000 compounds to reveal three drug candidates with comparable efficacy and superior medicinal chemistry properties than those of senolytics currently under investigation.

“This research result is a significant milestone for both longevity research and the application of artificial intelligence to drug discovery,” said Felix Wong, Ph.D., co-founder of Integrated Biosciences and first author of the publication. “These data demonstrate that we can explore chemical space in silico and emerge with multiple candidate anti-aging compounds that are more likely to succeed in the clinic, compared to even the most promising examples of their kind being studied today.”

I have important news on the 6th anniversary of the death of my father, Steven Gyurko. The award winning feature documentary on my life IMMORTALITY OR BUST has just had its international release! You can watch it for free on Plex TV anywhere in the world. The film features my US presidential campaign fighting for life extension and driving the Immortality Bus as my father is dying. Congrats to director Daniel Sollinger!

Immortality or Bust follows Zoltan Istvan’s Transhumanist Party presidential campaign.

Summary: The neuroscience of fitness explores how regular exercise profoundly impacts our brain and nervous system.

Exercise stimulates neurogenesis – the creation of new neurons – primarily in the hippocampus, influencing memory and learning while increasing key mood-regulating neurotransmitters. It also enhances brain plasticity, essential for recovery from injury and aging, and improves cognitive functions such as attention and memory.

Despite ongoing research, the current evidence underscores the powerful role of physical activity in promoting brain health and cognitive function, emphasizing the importance of integrating regular exercise into our lifestyles.

A new study in Nature hunted down another piece to the aging puzzle. In five species across the evolutionary scale—worms, flies, mice, rats, and humans—the team honed in on a critical molecular process that powers every single cell inside the body and degrades with age.

The process, called transcription, is the first step in turning our genetic material into proteins. Here, DNA letters are reworked into a “messenger” called RNA, which then shuttles the information to other parts of the cell to make proteins.

Scientists have long suspected that transcription may go awry with aging, but the new study offers proof that it doesn’t—with a twist. In all five of the species tested, as the organism grew older the process surprisingly sped up. But like trying to type faster when blindfolded, error rates also shot up.

Never heard of this fellow before but if you have a spare 50 minutes it’s a good listen. A summary of aging and what we might do about it with the goal (after about 26 minutes) of making an aging vaccine.

Lecture given by Dr. Ronjon Nag at “The Peter Wells Memorial Lecture 2023″ which took place in London on May 3rd, 2023.
https://events.theiet.org/events/the-peter-wells-memorial-lecture-2023/

Continue reading “Can We Live Longer than 120? Lecture” »

Researchers at Tufts University developed immortalized bovine muscle stem cells for cellular agriculture, potentially overcoming scaling challenges for meat production.

Andrew Stout, Tufts University.

Currently, it is difficult and expensive to produce cell-cultured meat because muscle and fat cells need to be able to grow and divide rapidly. Normal muscle stem cells can only divide about 50 times before they stop dividing and die. However, immortalized cells developed by the TUCCA team can divide indefinitely, which means they can produce much more meat.

Continue reading “Breakthrough in cellular agriculture, a game changer for cultured meat industry” »

Oldest known animal killed and secrets of immortality.

Ming the ocean quahog lived peacefully for over 500 years off the coast of Iceland. So why did a team of researchers dredge it up and kill it?

Discover the fascinating world of digital immortality and the pivotal role artificial intelligence plays in bringing this concept to life. In this captivating video, we delve into the intriguing idea of preserving our consciousness, memories, and personalities in a digital realm, potentially allowing us to live forever in a virtual environment. Unravel the cutting-edge AI technologies like mind uploading, AI-powered avatars, and advanced brain-computer interfaces that are pushing the boundaries of what it means to be alive.

Join us as we explore the ethical considerations, current progress, and future prospects of digital immortality. Learn about the ongoing advancements in brain-computer interfaces such as Neuralink, AI-powered virtual assistants like ChatGPT, and the challenges and opportunities that lie ahead. Will digital immortality redefine humanity’s relationship with life, death, and existence itself? Watch now to uncover the possibilities.

Continue reading “Digital Immortality Uncovered: How AI Could Help Us Live Forever” »