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Category: life extension – Page 111

Do you use biological age tests to quantify your fitness goals? I updated this piece with the latest products (there are a ton) and found a few discount codes too.

Update 10/2/2023: This post has been updated since we originally published it. I evaluated additional top biological age tests for 2024, removed companies that are no longer offering tests, and updated the post to reflect the most recent pricing. The post has been cleaned up and links were made current.

According to TikTok, I’m either 46-years-old, 37-years-old, or 29-years-old. As a 34-year-old woman, that’s, ahem, less than ideal.

TikTok offers a filter that guesses how old the user is based on their uploaded face. Pulling my long hair up into a ponytail ages me by over a decade, and standing in natural lighting makes me appear younger than I actually am.

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Gene therapy company Genflow Biosciences has received positive feedback from Belgium’s Federal Agency for Medicines and Health Products as it seeks to move into human clinical trials. Genflow is developing gene therapies that target the aging process, with a focus on reducing and delaying age-related diseases.

Genflow’s approach involves the use of adeno-associated virus (AAV) vectors to deliver copies of the Sirtuin-6 (SIRT6) gene variant found in centenarians into cells. Sirtuins are a group of proteins that play a vital role in regulating various cellular processes. In recent years, SIRT6 has gained attention for its potential role in promoting healthy aging.

Genflow says it has received written advice from the FAHMP to commence clinical trials of its lead compound (GF-1002) in patients suffering from NASH, an aggressive form of non-alcoholic fatty liver disease, rather than in healthy volunteers. While further discussions and agreement with the European Medicine Agency (EMA) are still required, Genflow says that it expects a NASH clinical trial to commence in approximately 18 months.

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The last 2 questions and the answers are great. The first starts at 30 minutes. And I like his answer to the 2nd question especially, the time is 33:54. “What is giving me great hope is that we’re entering the phases where we have more than enough tools to get really get close to escape velocity.”

Genome Engineering for Healthy Longevity – George Church at Longevity Summit Dublin 2023.

#GeorgeChurch #GenomeEngineering #HealthyLongevity #LongevitySummitDublin2023 #AgingResearch #DublinConference #LongevityScience #BiomedicalEngineering #GeneticModification #DublinTalks #GenomicInnovation #MedicalScience #LongevityResearch #PrecisionMedicine #AgingInterventions #Healthspan #GenomeEditing #AntiAging #LongevityInsights #Genetics #Innovation

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Insilico Medicine, a clinical-stage generative AI-driven drug discovery company has announced that the company has used Microsoft BioGPT to identify targets against both the aging process and major age-related diseases.

Longevity. Technology: ChatGPT – the AI chatbot – can craft poems, write webcode and plan holidays. Large language models (LLMs) are the cornerstone of chatbots like GPT-4; trained on vast amounts of text data, they have been contributing to advances in diverse fields including literature, art and science – but their potential in the complex realms of biology and genomics has yet to be fully unlocked.

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Stem cells from the human stomach can be converted into cells that secrete insulin in response to rising blood sugar levels, offering a promising approach to treating diabetes, according to a preclinical study from researchers at Weill Cornell Medicine.

In the study, which appeared April 27 in Nature Cell Biology, the researchers showed that they could take stem cells obtained from human stomach tissue and reprogram them directly—with strikingly high efficiency—into cells that closely resemble pancreatic insulin-secreting cells known as beta cells. Transplants of small groups of these cells reversed disease signs in a mouse model of diabetes.

“This is a proof-of-concept study that gives us a solid foundation for developing a treatment, based on patients’ own cells, for type 1 diabetes and severe type 2 diabetes,” said study senior author Dr. Joe Zhou, an associate professor of regenerative medicine and a member of the Hartman Institute for Therapeutic Organ Regeneration at Weill Cornell Medicine.

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Ageing has always been inevitable but fasting, epigenetic reprogramming and parabiosis are just some of the scientific techniques that seem to help people stay young. Might the Peter Pan dream become real?

00:00 — Can science turn back the clock?
01:01 — Centenarians.
02:51 — What is ageing?
04:51 — Dietary restriction.
06:00 — Roundworms.
07:55 — Epigenetics.
09:43 — Blood and guts.
11:40 — Senolytics.
12:38 — Metformin.
13:51 — Anti-ageing treatments are coming.

Sign up to The Economist’s daily newsletter: https://econ.st/3QAawvI

Read the Technology Quarterly on longevity: https://econ.st/462fqto.

Christian Californians may have a solution to America’s obesity: https://econ.st/3EC4GG9

How to eat to 100: https://econ.st/3EwQTAq.

Continue reading “Longevity: can ageing be reversed?” | >

Hospital nurseries routinely place soft bands around the tiny wrists of newborns that hold important identifying information such as name, sex, mother, and birth date. Researchers at Rockefeller University are taking the same approach with newborn brain cells—but these neonates will keep their ID tags for life, so that scientists can track how they grow and mature, as a means for better understanding the brain’s aging process.

As described in a new paper in Cell, the new method developed by Rockefeller geneticist Junyue Cao and his colleagues is called TrackerSci (pronounced “sky”). This low-cost, high-throughput approach has already revealed that while newborn cells continue to be produced through life, the kinds of cells being produced greatly vary in different ages. This groundbreaking work, led by co-first authors Ziyu Lu and Melissa Zhang from Cao’s lab, promises to influence not only the study of the brain but also broader aspects of aging and disease across the human body.

“The cell is the basic functional unit of our body, so changes to the cell essentially underlie virtually every disease and the aging process,” says Cao, head of the Laboratory of Single-Cell Genomics and Population Dynamics. “If we can systematically characterize the different cells and their dynamics using this novel technique, we may get a panoramic view of the mechanisms of many diseases and the enigma of aging.”

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Hearing diminishes as we age — about 50% of adults 75 and over in the United States have disabling hearing loss.

Age-related hearing loss cannot currently be stopped.

Researchers from the University of Guelph and Tufts.

University/Fatty Acid Research Institute have found a link between increased omega-3 fatty acids in the blood and less age-related hearing issues.

As we age, it is not uncommon for the effectiveness of some of our sensesTrusted Source — including vision, hearing, and tasteTrusted Source — to decrease.

In fact, research shows the rate of hearing loss increases with ageTrusted Source. In the United States, about 25% of people ages 65 to 74 and almost half of adults aged 75 and… More.

Continue reading “Omega-3 fatty acids may slow age related hearing loss” | >

An analysis of data from the Dunedin Multidisciplinary Health and Development study, a large longitudinal study in New Zealand, showed that participants with a history of antisocial behavior had a significantly faster pace of biological aging. When these individuals reached the calendar age of 45, they were on average 4.3 years older biologically compared to those who had lower levels of antisocial behavior. The study was published in the International Journal of Environmental Research and Public Health.

Antisocial behavior refers to actions that consistently violate social norms, disregard the rights of others, and often involve a lack of empathy or remorse. It involves behaviors such as deceitfulness, aggression, theft, violence, lying, and other behaviors that are harmful, manipulative, or exploitative towards others.

Antisocial behavior is typically associated with youth. This type of behavior starts between the ages of 8 and 14, peaks between 15 and 19, and usually becomes less frequent between the ages of 20 and 29. Although it becomes less common with age, it seems to have a lasting negative impact on health. Studies have shown that individuals who exhibit antisocial behaviors in their youth tend to have worse health outcomes as adults compared to their peers.

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