Lifeboat Foundation

To begin the process of bioprinting an organ, doctors typically start with a patient’s own cells. They take a small needle biopsy of an organ or do a minimally invasive surgical procedure that removes a small piece of tissue, “less than half the size of a postage stamp,” Atala said. “By taking this small piece of tissue, we are able to tease cells apart (and) we grow and expand the cells outside the body.”

This growth happens inside a sterile incubator or bioreactor, a pressurized stainless steel vessel that helps the cells stay fed with nutrients – called “media” – the doctors feed them every 24 hours, since cells have their own metabolism, Lewis said. Each cell type has a different media, and the incubator or bioreactor acts as an oven-like device mimicking the internal temperature and oxygenation of the human body, Atala said.

“Then we mix it with this gel, which is like a glue,” Atala said. “Every organ in your body has the cells and the glue that holds it together. Basically, that’s also called ‘extracellular matrix.’”.

A team from UT Dallas has discovered a molecule that destroys adamant cancer cells. Experiments on mice and human tissue found that the compound was effective even in the most aggressive tumors, offering hope.

“When the Human Genome Project began in 1990, it had a projected budget of $3 billion. […] Now, one company claims to have achieved the major milestone of whole genome sequencing for just $100.”

Ultima Genomics, a biotech company based in California, has emerged from stealth mode with a new high-throughput, low-cost sequencing platform that it claims can deliver a $100 genome.

When the Human Genome Project began in 1990, it had a projected budget of $3 billion. Some researchers believed it would take centuries to map all 20,000+ genes and to determine the sequence of chemical base pairs making up DNA, though in the end it took 13 years. Since then, genome sequencing has undergone technology and cost improvements at a rate faster than Moore’s Law (a long-term trend in the computer industry that involves a doubling of performance every two years). What used to require billions of dollars and many years of work is now several orders of magnitude cheaper and possible in a matter of hours.

Continue reading “Whole human genome sequencing for $100” »

Roswell Biotechnologies wants you to believe its new chip will revolutionize the detection of viruses, DNA, and more. But it still has to prove itself.

The U.K. has reported more than 300 cases.

The U.S. Centers for Disease Control and Prevention (CDC) ramped up its alert level for the ongoing monkeypox outbreak as the nation’s case count hit 30 and the global case count rose above 1,000.

The CDC now advises that travelers “practice enhanced precautions” to avoid contracting and spreading the rare viral disease, the agency’s website states (opens in new tab). The CDC says that people should avoid close contact with sick people, including those with rashes on their skin or genitals, and with dead or live wild animals, especially rodents, such as rats and squirrels, and non-human primates, meaning monkeys and apes.

Solving the 3D structure at near atomic level resolution, one of the world’s hardest, giant jigsaw puzzles—the nuclear pore complex—the largest molecular machine in human cells, with structure-based AI prediction @ScienceMagazine

We’ve been hearing a lot about synthetic skins designed for robotic hands, which would give the devices more human-like qualities. Well, scientists in Japan have gone a step further, by covering a robotic finger in a self-healing skin made from live human cells.

Led by Prof. Shoji Takeuchi, a team at the University of Tokyo started by building an articulated motor-driven robotic finger, capable of bending and straightening like its human counterpart. That finger was then submerged in a cylinder filled with a solution made up of collagen and human dermal fibroblast cells – these are the main components of our skin’s connective tissues.

Due to its natural properties, that solution shrank and conformed to the contours of the finger, forming a seamless hydrogel coating. Next, the scientists added a layer of human epidermal keratinocyte cells, which constitute 90 percent of our epidermis (the outermost layer of skin). These formed a moisture-retaining/water-resistant barrier on top of the gel, and gave the finger a more natural texture.

A small trial using the drug dostarlimab yielded an unprecedented success rate in eliminating tumors.

Wojtek Tek.

Tenor.

Continue reading “Inside the US lab freezing the dead at —196C — BBC REEL” »