Lifeboat Foundation

Ken OtwellIt’s an awkward situation. Was the engineer continuing to do his job? Was his public claim about internal corporate technology interfering with his duties or causing harm to Google? Was it breaking a voluntary non-disclosure?

Kevin CuevasWith neurocyte based computing, it is a question worth exploring since we are already blurring that line anyway.

Continue reading “Growing Human Neurons Connected to a Computer” »

In cancer, healthy cells turn into malignant ones with very different characteristics, such as the ability to divide in an uncontrolled manner. In recent decades, much research has uncovered various molecular alterations responsible for this conversion from healthy to tumor tissue. But until now, scientists have known very little about the opposite process – reversing a cancer cell, turning it into a physiological, noncancerous one, and what factors might mediate this process.

“We know that one strategy that human tumors have to dodge the effectiveness of drugs is to change their appearance, becoming another similar cancer but insensitive to the drug used,” the team said. “For example, leukemias of the lymphoid lineage are switched to the myeloid strain to escape treatment.”

With this idea in mind, they wanted to know more about the molecular pathways involved in this cellular transformation. They studied an in vitro model (experiment performed outside of a living organism, usually in a test tube or petri dish) in which leukemia cells can be forced to turn into a type of harmless immune cells called macrophages.

Cancer, in the simplest terms, is the transformation of normal cells into malignant ones that grow and divide uncontrollably. It, however, is not one disease but a group of more than 100 different and distinctive diseases, and leukemia, or blood cancer, is just one of them. Leukemia begins in…

David Sinclair shares another side of himself. Compassion for all people. He wants to make sure that longevity technologies are available for all people, not just for the super wealthy and their pets. He also speaks of emerging elderly populations who can live well up until death rather than suffering for so long, and instead start new careers and hobbies.

Researchers have restored vision in animal by resetting some of the thousands of chemical marks that accumulate on DNA as cells age. The work, by Dr David Sinclair Lab, published in Nature Dec 2020, suggests a new approach to reversing age-related decline, by reprogramming some cells to a ‘younger’ state in which they are better able to repair or replace damaged tissue.

Continue reading “Boost NAD, Reprogramme Our Cells to be Young Again | Dr David Sinclair Interview Clips” »

The application of mechanic forces to the cell nucleus affects the transport of proteins through the nuclear membrane, an action that controls cellular processes and could play a key role in several diseases such as cancer. These findings draw a new scenario for understanding how the mechanic forces drive the progression of cancer and open the doors to the design of potential innovative techniques—both diagnostic and therapeutic. This is the conclusion of a study published in the journal Nature Cell Biology led by lecturer Pere Roca-Cusachs, from the Faculty of Medicine and Health Sciences of the University of Barcelona, the Institute of Nanoscience and Nanotechnology of the UB (IN2UB) and the Institute for Bioengineering of Catalonia (IBEC).

The cells in the body receive mechanical stimuli from their environment and respond accordingly regarding decisions on how and when to grow, move and differentiate. The process is known as mechanotransduction and it is critically important for the cell function and for human health.

The study reveals that the direct application of force to the nucleus can affect the spatial organization of the DNA and the activity of nuclear proteins, among other functions. When cancer cells invade the organs and metastasis appears, these create physical forces that are transmitted to the cell nucleus.

Gabapentin, which is currently used to control seizures and manage nerve pain, might help nerve cells regrow in the brain.

Holes help make sponges and English muffins useful (and, in the case of the latter, delicious). Without holes, they wouldn’t be flexible enough to bend into small crevices, or to sop up the perfect amount of jam and butter.

In a new study, University of Chicago scientists find that holes can also improve technology, including medical devices. Published in Nature Materials, the paper describes an entirely new way to make a solar cell: by etching holes in the top layer to make it porous. The innovation could form the basis for a less-invasive pacemaker, or similar medical devices. It could be paired with a small light source to reduce the size of the bulky batteries that are currently implanted along with today’s pacemakers.

“We hope this opens many possibilities for further improvements in this field,” said Aleksander Prominski, the first author on the paper.

A major campaign of domino-toppling simulations yields new insights into the effects of friction.

Despite the apparent simplicity of toppling dominoes, physicists still don’t have a complete model of the phenomenon. But new numerical simulations get a step closer by untangling the influence of two types of friction—one between neighboring dominoes and the other between each domino and the surface beneath it [1]. The researchers found that, in some cases, these two friction coefficients play competing roles in determining the speed of the domino cascade. They also found that one of the coefficients behaves similar to friction in granular systems such as piles of sand or pharmaceutical pills, suggesting that the domino simulations may provide insights into other situations where friction is important.

Continue reading “Friction Is Key in Domino Physics” »

Circa 2016

Reports that scientists have created “the first fully living dinosaur embryo in millions of years” using DNA from chicken skin are fake news.