Lifeboat Foundation

And researchers have hailed it as a breakthrough.

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Continue reading “Bile Acids: The Next Frontier In Longevity?” »

By making remarkable breakthroughs in a number of fields, unlocking new approaches to science, and accelerating the pace of science and innovation.

In 2020, Google’s AI team DeepMind announced that its algorithm, AlphaFold, had solved the protein-folding problem. At first, this stunning breakthrough was met with excitement from most, with scientists always ready to test a new tool, and amusement by some. After all, wasn’t this the same company whose algorithm AlphaGo had defeated the world champion in the Chinese strategy game Go, just a few years before? Mastering a game more complex than chess, difficult as that is, felt trivial compared to the protein-folding problem. But AlphaFold proved its scientific mettle by sweeping an annual competition in which teams of biologists guess the structure of proteins based only on their genetic code. The algorithm far outpaced its human rivals, posting scores that predicted the final shape within an angstrom, the width of a single atom. Soon after, AlphaFold passed its first real-world test by correctly predicting the shape of the SARS-CoV-2 ‘spike’ protein, the virus’ conspicuous membrane receptor that is targeted by vaccines.

The success of AlphaFold soon became impossible to ignore, and scientists began trying out the algorithm in their labs. By 2021 Science magazine crowned an open-source version of AlphaFold the “Method of the Year.” Biochemist and Editor-in-Chief H. Holden Thorp of the journal Science wrote in an editorial, “The breakthrough in protein-folding is one of the greatest ever in terms of both the scientific achievement and the enabling of future research.” Today, AlphaFold’s predictions are so accurate that the protein-folding problem is considered solved after more than 70 years of searching. And while the protein-folding problem may be the highest profile achievement of AI in science to date, artificial intelligence is quietly making discoveries in a number of scientific fields.

Continue reading “AI is Ushering In a New Scientific Revolution” »

A new CRISPR-based map ties every human gene to its function using a tool called Perturb-seq. The work was led by Jonathan Weissman and colleagues at MIT and the Whitehead Institute, and is free for other scientists to use.

A new molecule synthesized by a University of Texas at Dallas researcher kills a broad spectrum of hard-to-treat cancers, including triple-negative breast cancer, by exploiting a weakness in cells not previously targeted by other drugs.

A study describing the research — which was carried out in isolated cells, in human cancer tissue and in human cancers grown in mice — was published online June 2 in the journal Nature Cancer.

Dr. Jung-Mo Ahn, a co-corresponding author of the study and a UT Dallas associate professor of chemistry and biochemistry in the School of Natural Sciences and Mathematics, has been passionate about his work designing small molecules that target protein-protein interactions in cells for over a decade. Using an approach called structure-based rational drug design, he previously developed potential therapeutic candidate compounds for treatment-resistant breast cancer and for prostate cancer.

Liz mentions combinatorial gene therapy for aging near the end which is something you hear the likes of George Church mention they are working on.

Liz Parrish is the founder of @BioViva Science, a company dedicated to curing biological aging, a disease that is at the root cause of all other chronic diseases from heart disease to Alzheimer’s. Watch this video to understand how much more control we have over our lifespan and health!

Continue reading “How To Live Forever with BioViva’s Liz Parrish! The LONGEVITY revolution has begun!” »

There are at least 10,000 virus species in vertebrate animals with the capacity to infect humans. Climate change will facilitate this.

Research study forecasts that 4,000 diseases currently found in the wild will leap to humans in the next 50 years.

The reluctance of many in the medical field to classify aging as a disease is causing significant roadblocks for those trying to find a solution.

Many people will swear to the life extending properties of coffee, be it saving them from keeling over from exhausting in the early hours of the morning or saving an annoying co-worker from the unbridled rage of someone who hasn’t yet acquired their caffeine fix. Yes, coffee is without a doubt one of the most powerful (and mostly metaphorical) lifesavers of the modern world. However, recent studies into the effects of drinking coffee on human lifespan have found that it might very well have a significant impact on health and longevity. A study of 170,000 people from the UK found that those who drank between two and four cups of coffee a day were 30% less likely to die from all causes compared to those who did not drink coffee at all.

Summary: An older person’s posture may give clues to hidden cognitive decline, a new study reports.

Source: Shinshu University.

A mass survey of citizens aged 50 to 89 years examined whether cognitive decline could be detected by sagittal spinal balance measurement based on a radiological approach. Doctors from Shinshu University observed associations of sagittal vertical axis (SVA) anteriorization and higher age with lower cognitive function.