Lifeboat Foundation

Unlike chemotherapy or radiation, which attack cancer directly, CAR-T engineers patients’ immune cells so they can do it themselves. T-cells are removed from the blood and given new genes that produce receptors that let the T-cells recognize and bind to leukemia cells with a specific protein, CD19.

The genetically modified T-cells are then multiplied in the lab and infused back into the patient, where they ideally multiply even further and begin to target and kill cancer cells with CD19.

Researchers at Rensselaer Polytechnic Institute have developed a way to 3D print living skin, complete with blood vessels. The advancement, published online today in Tissue Engineering Part A, is a significant step toward creating grafts that are more like the skin our bodies produce naturally.

“Right now, whatever is available as a clinical product is more like a fancy Band-Aid,” said Pankaj Karande, an associate professor of chemical and biological engineering and member of the Center for Biotechnology and Interdisciplinary Studies (CBIS), who led this research at Rensselaer. “It provides some accelerated wound healing, but eventually it just falls off; it never really integrates with the host cells.”

Continue reading “Living skin can now be 3D-printed with blood vessels included” »

https://youtube.com/watch?v=jtNsxqG4AfQ

Oct. 29 is World Stroke Day. Sometimes called a brain attack, stroke is the second leading cause of death worldwide and the fifth leading cause of death in the U.S. Men and women are at risk of a stroke, but women are more likely to have – and die – of a stroke than men. Dr. Kara Sands, a Mayo Clinic neurologist, says stroke kills twice as many women as breast cancer. The good news is that strokes are preventable, treatable and beatable.

Watch: The Mayo Clinic Minute

Continue reading “Mayo Clinic Minute: What you need to know about stroke” »

The first person known to die as a result of a fecal transplant is a 73-year-old man who developed a fatal infection with antibiotic-resistant bacteria that were in the donor’s stool sample.

News of the man’s death surfaced in June; he was one of two patients in separate clinical trials who became ill after receiving fecal transplants from the same donor, Live Science previously reported.

Bacterial infections that are resistant to treatment by our existing antibiotics are a huge threat to human health — and an enormous challenge for medicine. Scientists are exploring one fascinating line of research: compounds modeled after those found in the blood of the fearsome Komodo dragon.

One of the most intriguing developments in the so-called golden age of neuroscience has been the growing understanding of “neuroplasticity”: the brain’s ability to constantly reshape itself and constantly learn new things by forging new connections throughout one’s lifetime — to grow proportions of gray matter and even shift brain activity to different regions of the brain.

Now a new research effort is taking the concept of neuroplasticity further — looking at diseased and injured brains that have permanently lost neurons. The effort, led by neuroscientist Magdalena Götz, explores whether “astrocytes” — non-neuronal, structural cells in the brain, can be reprogrammed to take up the tasks the neurons once performed.

“Everybody is astonished, at the moment, that it works,” says Nicola Mattugini, a neurobiologist at the Ludwig Maximilian University of Munich, Germany, when she presented her team’s results at the annual meeting of the Society for Neuroscience in San Diego, California. Their team reprogrammed the astrocytes in lab mice.

We’re continuing to release talks from Ending Age-Related Diseases 2019, our highly successful two-day conference that featured talks from leading researchers and investors, bringing them together to discuss the future of aging and rejuvenation biotechnology.

Sree Kant of Life Biosciences discussed investment and R&D in an aging world, demonstrating the necessity of rejuvenation biotechnology in keeping people over the age of 65 healthy and productive. He showed that we need effective treatments for the root causes of aging rather than just downstream conditions, bringing up the necessity of a broad rejuvenation ecosystem that uses VC and other investment to fund companies that focus on these root causes.

But there has never been a good explanation for this connection.

“It’s been known for a long time that sleep is really important for brain health,” Lewis says, “but why it is was more mysterious.”

Lewis and a team of researchers wanted to solve the mystery.

A pair of new studies report “impressive” benefits from a drug therapy for cystic fibrosis, a deadly and devastating disease that affects tens of thousands of people worldwide, the director of the National Institutes of Health wrote in an editorial published in The New England Journal of Medicine on Thursday.

“These findings indicate that it may soon be possible to offer safe and effective molecularly targeted therapies to 90 percent of persons with cystic fibrosis,” wrote the director, Dr. Francis S. Collins, who led the team that in 1989 identified the gene that causes the genetic disease affecting the lungs and digestive system.

“This should be a cause for major celebration,” he wrote in the Thursday editorial.