Lifeboat Foundation

The answer to halting triple-negative breast cancer, the deadliest of all breast cancers, may have just been discovered by researchers from Boston Children’s Hospital.

A CRISPR gene-editing system — all encompassed into a nanogel capsule, that is then injected into the affected person’s body — is the potential antidote to stopping the growth of triple-negative breast cancer tumors.

Continue reading “CRISPR Nanogel Pill Could Be the Answer to Stop Triple-Negative Breast Cancer” »

One way that scientists can non-invasively study the human brain is by growing “mini-brains,” clusters of brain cells each about the size of a pea, in the lab. In a fascinating progression of this line of research, a team this week reports that they observed human-like brainwaves from these organoids.

Previous studies of mini-brains have demonstrated movement and nerve tract development, but the new study from researchers at the University of California San Diego, led by biologist Alysson Muotri, is the first to record human-like neural activity. In their paper, published in Cell Stem Cell on Thursday, the researchers write that they observed brain wave patterns resembling those of a developing human. This sophistication in the in vitro model is a step to enable scientists to use mini-brains to study brain development, model diseases, and learn about the evolution of brains, according to Muotri.

Scientists have created miniature brains from stem cells that developed functional neural networks. Despite being a million times smaller than human brains, these lab-grown brains are the first observed to produce brain waves that resemble those of preterm babies. The study, published August 29 in the journal Cell Stem Cell, could help scientists better understand human brain development.

“The level of neural activity we are seeing is unprecedented in vitro,” says Alysson Muotri, a biologist at the University of California, San Diego. “We are one step closer to have a model that can actually generate these early stages of a sophisticated neural network.”

The pea-sized brains, called cerebral organoids, are derived from human pluripotent stem cells. By putting them in culture that mimics the environment of brain development, the stem cells differentiate into different types of brain cells and self-organize into a 3D structure resembling the developing human brain.

As part of continuing efforts to ensure their vehicles are the safest cars on the road, Tesla’s “Bug Bounty” program gives awards to security researchers that uncover vulnerabilities in the company’s various product systems. Perhaps one of the most impressive parts of that program, however, is Tesla’s ability to remedy the flaws quickly. In the most recent example of their dedication to security, a Bug Bounty find from April this year is now being patched via an over-the-air (OTA) update in 2019.32.

Last year, a Tesla Model S key fob was hacked by a team led by Lennert Wouters of Katholieke Universiteit Leuven in Belgium (KU Leuven). The security flaw enabled would-be car thieves to clone a fob in less than two seconds, after which the vehicle could be driven off. Tesla subsequently offered a multi-part fix: PIN to Drive, a software update, and a new fob. Wouters again found a very similar flaw in the new fob, but this time the fix only required an OTA update which patched both the vehicle software and the fob’s configuration via radio waves.

Dr. Mike Chan, Stellar Biomolecular Reserch, chats with James Strole, Director of the Coalition for Radical Life Extension, about what he’s bringing to RAADfest 2019: age reversal of organs using cell and stem cell therapies.

For more info and to register: http://www.raadfest.com/

Organized by the Coalition for Radical Life Extension, RAADfest is the largest event in the world where practical and cutting-edge methods to reverse aging are presented for all interest levels, from beginner to expert. An interactive, inclusive event featuring dozens of top presenters in life extension, regenerative medicine, super longevity, lifestyle, genetics, life hacking, finances, and more. RAADfest will also feature activists and advocate entertainers, celebrations, RAADcity the Expo and RAADclinic.

Continue reading “Organ Age Reversal with Stem Cells” »

The first international case of listeriosis linked to an outbreak in Spain that has sickened almost 200 people and killed two is being investigated by British public health officials.

The outbreak has been traced to contaminated chilled pork products under the brand “La Mechá” made by Magrudis, based in Seville. The potential infection is in a man from England who ate the product in Seville in mid-August. He was treated at a hospital in France before returning to the United Kingdom.

A Public Health England spokeswoman told Food Safety News the agency does not disclose patient details so she was not able to provide information on the age of the man or where in England he lives.

Small-scale soft continuum robots capable of active steering and navigation in a remotely controllable manner hold great promise in diverse areas, particularly in medical applications. Existing continuum robots, however, are often limited to millimeter or centimeter scales due to miniaturization challenges inherent in conventional actuation mechanisms, such as pulling mechanical wires, inflating pneumatic or hydraulic chambers, or embedding rigid magnets for manipulation. In addition, the friction experienced by the continuum robots during navigation poses another challenge for their applications. Here, we present a submillimeter-scale, self-lubricating soft continuum robot with omnidirectional steering and navigating capabilities based on magnetic actuation, which are enabled by programming ferromagnetic domains in its soft body while growing hydrogel skin on its surface. The robot’s body, composed of a homogeneous continuum of a soft polymer matrix with uniformly dispersed ferromagnetic microparticles, can be miniaturized below a few hundreds of micrometers in diameter, and the hydrogel skin reduces the friction by more than 10 times. We demonstrate the capability of navigating through complex and constrained environments, such as a tortuous cerebrovascular phantom with multiple aneurysms. We further demonstrate additional functionalities, such as steerable laser delivery through a functional core incorporated in the robot’s body. Given their compact, self-contained actuation and intuitive manipulation, our ferromagnetic soft continuum robots may open avenues to minimally invasive robotic surgery for previously inaccessible lesions, thereby addressing challenges and unmet needs in healthcare.

Small-scale soft continuum robots capable of navigating through complex and constrained environments hold promise for medical applications (1–3) across the human body (Fig. 1A). Several continuum robot concepts have been commercialized so far, offering a range of therapeutic and diagnostic procedures that are safer for patients owing to their minimally invasive nature (4–6). Surgeons benefit from remotely controlled continuum robots, which allow them to work away from the radiation source required for real-time imaging during operations (5, 6).

Despite these advantages, existing continuum robots are often limited to relatively large scales due to miniaturization challenges inherent in their conventional actuation mechanisms, such as pulling mechanical wires or controlling embedded rigid magnets for manipulation. Tendon-driven continuum robots (7–10) with antagonistic pairs of wires are difficult to scale down to submillimeter diameters due to increasing complexities in the fabrication process as the components become smaller (11–13). The miniaturization challenges have rendered even the most advanced form of commercialized continuum robots, mostly for cardiac and peripheral interventions (14), unsuited for neurosurgical applications due to the considerably smaller and more tortuous vascular structures. Magnetically steerable continuum robots (15–19) have also remained at large scale because of the finite size of the embedded magnets required to generate deflection under applied magnetic fields.

Synthetic biological circuits are promising tools for developing sophisticated systems for medical, industrial, and environmental applications. So far, circuit implementations commonly rely on gene expression regulation for information processing using digital logic. Here, we present a different approach for biological computation through metabolic circuits designed by computer-aided tools, implemented in both whole-cell and cell-free systems. We first combine metabolic transducers to build an analog adder, a device that sums up the concentrations of multiple input metabolites. Next, we build a weighted adder where the contributions of the different metabolites to the sum can be adjusted. Using a computational model fitted on experimental data, we finally implement two four-input perceptrons for desired binary classification of metabolite combinations by applying model-predicted weights to the metabolic perceptron. The perceptron-mediated neural computing introduced here lays the groundwork for more advanced metabolic circuits for rapid and scalable multiplex sensing.