Longevity drugs for our canine companions are moving closer to reality. They also raise questions about what it might mean to succeed.
A new study in mice found limited intakes of one particular essential amino acid slowed the impacts of ageing and even lengthened their lifespan.
Scientists are now wondering if these findings could help people improve their longevity and quality of life.
Isoleucine is one of three branched-chain amino acids we use to build proteins in our bodies. It is essential for our survival, but since our cells can’t produce it from scratch, we have to get it from sources like eggs, dairy, soy protein and meats.
Life expectancy and healthy aging in mice can be determined by a protein present in some cells of the immune system, according to a study published in the journal Cell Reports. When this protein—known as the CD300f immune receptor—is absent, animal models have a shorter life expectancy and suffer from pathologies associated with cognitive decline and premature aging, especially in females.
“Our study indicates that alterations in immune system cells, for instance, in macrophages and microglia, can determine the healthy aging degree in mice,” notes Hugo Peluffo, leader of this study and member of the Faculty of Medicine and Health Sciences and the Institute of Neurosciences (UBneuro) of the University of Barcelona.
Understanding how the CD300f immune receptor —and the myeloid cells of the immune system—can determine by themselves the onset rate of aging-associated pathologies, “will help to better understand this process, and it will contribute to the design of strategies to regulate its action. For instance, using the immune receptor CD300f as a target in biomedicine,” notes the expert. “Also, our team has previously shown that some variants of the CD300f immune receptor could be useful as biomarkers in patients.”
New research suggests that biological age, as indicated by DNA methylation, more significantly impacts cognitive abilities like memory and processing speed than chronological age. This finding could reshape our understanding of aging and cognitive health.
A new study in mice and monkeys suggests that one ingredient to a longer, healthier life may be taurine, a micronutrient commonly found in energy drinks.
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The technique represents an important step in engineering skin grafts, drug testing. A team led by scientists at Rensselaer Polytechnic Institute has 3D-printed hair follicles in human skin tissue cultured in the lab. This marks the first time researchers have used the technology to generate hair follicles, which play an important role in skin healing and function.
The finding, published in the journal Science Advances, has potential applications in regenerative medicine and drug testing, though engineering skin grafts that grow hair are still several years away.
“Our work is a proof-of-concept that hair follicle structures can be created in a highly precise, reproducible way using 3D-bioprinting. This kind of automated process is needed to make future biomanufacturing of skin possible,” said Pankaj Karande, Ph.D., an associate professor of chemical and biological engineering and a member of Rensselaer’s Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies, who led the study.
Bryan Johnson, 45, is using his life as a science experiment to see how long he can live and to reverse signs of aging as he goes. NBC News’ Gadi Schwartz reports.
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In particular I like the 3D modeling segment.
Here Dr Seranova talks about stem cell use in helping with research into diseases of aging, particularly generating organiods of the brain by growing them from stem cells.
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Two Eötvös Loránd University researchers have made an exciting breakthrough in understanding how we age.
Researchers Dr. Ádám Sturm and Dr. Tibor Vellai from Eötvös Loránd University in Hungary have achieved a significant discovery in the study of aging. Their research centered on “transposable elements” (TEs) in our DNA
DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).
