This Collection invites multidisciplinary groups to submit their research in Generative Artificial Intelligence for aging research and drug discovery.
Category: life extension – Page 67
New Implant Will Help Patients Regenerate Their Own Heart Valves
Every year, more than 5 million people in the USA are diagnosed with heart valve disease, but this condition has no effective long-term treatment. When a person’s heart valve is severely damaged by a birth defect, lifestyle, or aging, blood flow is disrupted. If left untreated, there can be fatal complications.
Valve replacement and repair are the only methods of managing severe valvular heart disease, but both often require repeated surgeries that are expensive, disruptive, and life-threatening. Most replacement valves are made of animal tissue and last up to 10 or 15 years before they must be replaced. For pediatric patients, solutions are extremely limited and can require multiple reinterventions.
Now, Georgia Tech researchers have created a 3D-printed heart valve made of bioresorbable materials and designed to fit an individual patient’s unique anatomy. Once implanted, the valves will be absorbed by the body and replaced by new tissue that will perform the function that the device once served.
Georgia Tech researchers have developed a groundbreaking 3D-printed, bioresorbable heart valve that promotes tissue regeneration, potentially eliminating the need for repeated surgeries and offering a transformative solution for both adult and pediatric heart patients.
Visceral Fat Removal Extends Lifespan: Which Factors May Reduce Visceral Fat?
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Autophagy, aging, and age-related neurodegeneration
This review discusses the links between the autophagy pathway, aging, and age-associated neurodegeneration in Alzheimer’s, Parkinson’s, motor neuron, and Huntington’s diseases. The authors highlight the functions of autophagy in neurons and glia and how aging and neurodegenerative diseases affect autophagy.
Medical Breakthroughs May Mean That More People Will Live To Be Over 100
Medical breakthroughs could mean that more of us will live to be 100 or even more, according to longevity medicine expert Dr. Edouard Debonneuil co-founder of the London-based Longevity Clinic who says that modern technology, new medicine, additional medical breakthroughs, and healthy living could help more of us reach that mammoth milestone.
“If the current trend continues, we could see individuals living to 140 or 150 in good health. While that might sound sensational, it’s grounded in science and the longevity field is booming because of these breakthroughs,” said Dr. Debonneuil after a first-of-its-kind study, Rejuvenation Olympics, which produced promising anti-aging results.
“One of the guys taking part is in his 60’s but biologically he resembles someone in their later 30’s. Some participants halved their biological age within two to three years and have reduced their ageing rate by 40 percent. This is a significant leap in human history, we now have the tools to age slowly,” continued Debonneuil.
Breakthrough Drug Reverses Aging in Skin, Speeds Up Healing
Topical ABT-263 effectively reduced several senescence markers in aged skin, preparing it for improved wound healing. Researchers from Boston University’s School of Medicine have identified a promising treatment that could improve wound healing in aging skin. Their study, published in the journal Aging, reveals that the drug ABT-263 can significantly accelerate skin repair by eliminating old, damaged cells known as senescent cells.
Frontiers: Cellular aging is a multifactorial and intricately regulated physiological process with profound implications
The interaction between cellular senescence and cancer is complex and multifaceted, senescence can both promote and inhibit tumor progression through various mechanisms. M6A methylation modification regulates the aging process of cells and tissues by modulating senescence-related genes. In this review, we comprehensively discuss the characteristics of cellular senescence, the signaling pathways regulating senescence, the biomarkers of senescence, and the mechanisms of anti-senescence drugs. Notably, this review also delves into the complex interactions between senescence and cancer, emphasizing the dual role of the senescent microenvironment in tumor initiation, progression, and treatment. Finally, we thoroughly explore the function and mechanism of m6A methylation modification in cellular senescence, revealing its critical role in regulating gene expression and maintaining cellular homeostasis. In conclusion, this review provides a comprehensive perspective on the molecular mechanisms and biological significance of cellular senescence and offers new insights for the development of anti-senescence strategies.
Cellular senescence is a complex and multifaceted biological process characterized by a stable arrest of the cell cycle in response to various stressors, such as DNA damage, oxidative stress, and oncogene activation (1). Although senescent cells no longer proliferate, they remain metabolically active and exhibit distinct phenotypic changes, including the secretion of pro-inflammatory factors, collectively termed the senescence-associated secretory phenotype (SASP) (2, 3). Senescence plays dual roles in physiological and pathological contexts: it is essential for processes like tissue remodeling, wound healing, and tumor suppression, yet its accumulation contributes to aging, chronic inflammation, and the progression of age-related diseases, including cancer and neurodegenerative disorders (4). Understanding the mechanisms underlying cellular senescence is crucial for developing therapeutic strategies to harness its beneficial aspects while mitigating its detrimental effects.
Could AI Stop Aging by 2032? Exploring Kurzweil’s Predictions
The quest to halt or reverse aging has long captivated human imagination. By 2032, could artificial intelligence (AI) make this aspiration a reality? Futurist Ray Kurzweil, renowned for his forward-thinking predictions, believes so. He envisions a future where AI plays a pivotal role in achieving “longevity escape velocity,” a state where life expectancy increases more than one year per year, effectively outpacing aging.
Anti-Aging Breakthrough: Scientists Discover a Natural Antioxidant That Could Stop Gray Hair
A study from Nagoya University.
Nagoya University, sometimes abbreviated as NU, is a Japanese national research university located in Chikusa-ku, Nagoya. It was the seventh Imperial University in Japan, one of the first five Designated National University and selected as a Top Type university of Top Global University Project by the Japanese government. It is one of the highest ranked higher education institutions in Japan.
