Choanoflagellates, animals’ closest relatives, have pluripotency genes, reshaping views on their evolution.
The research highlights how evolution repurposes existing genetic tools, turning them into versatile drivers of innovation. This adaptability underscores how foundational processes in unicellular organisms laid the groundwork for the development of complex life forms.
Beyond rewriting evolutionary biology, the findings could revolutionize regenerative medicine. Understanding how ancient genes enabled pluripotency offers new pathways to refine stem cell therapies and enhance cell reprogramming techniques.
For instance, synthetic versions of these genes might outperform native animal genes, opening possibilities for more efficient treatments for diseases or tissue damage.
Genes aren’t the sole driver instructing cells to build multicellular structures, tissues, and organs. In a paper published in Nature Communications, USC Stem Cell scientist Leonardo Morsut and Caltech computational biologist Matt Thomson characterize the influence of another important developmental driver: cell density, or how loosely or tightly cells are packed into a given space.
In both computational models and laboratory experiments, the team of scientists used cell density as an effective tool for controlling how mouse cells pattern themselves into complex structures.
“This paper represents progress towards our big picture goal of engineering synthetic tissues,” said Morsut, an assistant professor of stem cell biology and regenerative medicine, and biomedical engineering at the Keck School of Medicine of USC.
We converted the calculations in Morgan Levine and Steve Horvath’s famous research paper on phenotypic age into a free biological age calculator.
It’s a great (cheap) alternative to $400 epigenetic age tests and means you can test more frequently to see if longevity interventions are actually…
This free biological age calculator is based on a pioneering paper by longevity experts Dr. Morgan Levine and Dr. Steve Horvath.
The paper, titled “An epigenetic biomarker of aging for lifespan and healthspan,” used some super-advanced machine learning techniques to find blood biomarkers which are significantly correlated with aging-related health outcomes, including mortality.
Essentially, they are able to use the results from this test to predict how near (or far away) you are from death.
Basically bio electricity once controlled could offer eternal life for humans because we could simply use the electricity to have longer if not indefinite lifespans that don’t require as much food for energy.
In the near future, birth defects, traumatic injuries, limb loss and perhaps even cancer could be cured through bioelectricity—electrical signals that communicate to our cells how to rebuild themselves. This innovative idea has been tested on flatworms and frogs by biologist Michael Levin, whose research investigates how bioelectricity provides the blueprint for how our bodies are built—and how it could be the future of regenerative medicine.
Levin is a professor of biology at Tufts University and director of the Tufts Center for Regenerative and Developmental Biology.
Unlock the Secret to a Longer, Healthier Life: The Power of Inhibiting IL-11 Discover the groundbreaking science behind aging in this video, Mr. Bill Faloon presents: • The Role of IL-11 in Aging: Learn how this inflammatory cytokine accelerates aging and contributes to age-related diseases. • The Benefits of Inhibiting IL-11: Discover how reducing IL-11 levels can lead to increased lifespan, improved health, and a more youthful appearance. • Natural Ways to Inhibit IL-11: Learn about dietary supplements and lifestyle habits that can help you lower IL-11 levels. • The Future of Anti-Aging Medicine: Explore the latest research on drugs and therapies targeting IL-11 and how they may revolutionize the way we approach aging.
Summary: Scientists have reprogrammed mouse cells into pluripotent stem cells using a gene from choanoflagellates, single-celled organisms related to animals. This breakthrough demonstrates that key genes driving stem cell formation existed in unicellular ancestors nearly a billion years ago.
The resulting stem cells were used to create a chimeric mouse, showcasing how ancient genetic tools can integrate with modern mammalian biology. This discovery redefines the evolutionary origins of stem cells and may inform regenerative medicine advancements.
Step Into the Future with The Cybernetic Singularity: The Syntellect Emergence 🎧 The groundbreaking third volume of The Cybernetic Theory of Mind series by Alex M Vikoulov is now available as an audiobook!
Ecstadelic Media Group releases a new non-fiction audiobook The Cybernetic Singularity: The Syntellect Emergence, in addition to a previously published Kindle eBook, part of The Cybernetic Theory of Mind series. Written by Alex M. Vikoulov; Narrated by Virtual Voice; Foreword by Antonin Tuynman, PhD; Format: Audible audiobook (Press Release, Burlingame, CA, USA, November 16, 2024 09.23 AM PST)
The Cybernetic Singularity: The Syntellect Emergence is a visionary exploration of humanity’s impending transition into a post-biological state of existence, where artificial intelligence, advanced cybernetics, and collective intelligence converge to form a unified Global Mind. As the third installment in The Cybernetic Theory of Mind series, this book delves into the transformative potential of AI and the emergence of hyperconnected “infomorphs” — substrate-independent minds transcending biological limitations. It examines the profound philosophical, technological, and existential implications of this evolutionary leap, which may redefine what it means to be human. The book also introduces key concepts like Cybernetic Immortality and Experiential Realism, suggesting how we might engineer a future of infinite creativity and bliss.
With the Syntellect Hypothesis as its foundation, The Cybernetic Singularity presents a roadmap to the ultimate phase transition of civilization — the awakening of a universal consciousness network capable of synthesizing knowledge, experience, and purpose at unimaginable scales. From the rise of transhumanism to the development of a planetary superorganism, the narrative connects cutting-edge scientific insights with metaphysical musings on the nature of reality. Opening with Norbert Wiener’s quote, “The world of the future will be an even more demanding struggle against the limitations of our intelligence,” the book invites readers to contemplate their role in this grand cosmic drama. Whether you are a technophile, philosopher, or futurist, this volume is an essential guide to understanding and embracing the dawn of the Syntellect Emergence.
