I realize this will step on a lot of toes, but, its time to accept that the AI will be what solves it.
Targeting aging may extend the average life expectancy more substantially than prevention or treatment of individual diseases.
For centuries, scientists have tried to work on formulas to extend human life. While scientific and medical advancements have pushed the average human life expectancy to 71 years worldwide, researchers are still trying to find out if it can be extended further. Now, a group of scientists is leaning on artificial intelligence (AI) to combine conventional medicine to treat diseases and prevent them to extend longevity.
Conventional medicine has been the go-to tool for scientists to treat diseases and effectively extend life expectancy. But it has limitations too. While it can treat diseases, it’s not very effective in detecting early signs of an ailment that can reduce life expectancy. But combining AI, fundamental research and medicine could bring about a change in the research of extending human life. Dubbed as Longevity medicine, the scientists — Alex Zhavoronkov, Evelyne Yehudit Bischof and Kai-Fu Lee — proposed a framework. Their article was published in the journal Nature Aging.
Dr Zhavoronkov is a computer scientist with a doctorate in biophysics. Bischof is a practicing doctor who is researching on aging and gerooncology at the University Hospital Basel in Switzerland. Lee is known for his expertise in AI.
This is the first part of the interview with Harold Katcher in Modern Healthspan YouTube channel.
Dr. Harold Katcher is a professor of Biology at the University of Maryland. He has been a pioneer in the field of cancer research, in the development of modern aspects of gene hunting and sequencing. He carries expertise in bioinformatics, chronobiology, and biotechnology. Dr. Katcher is currently working in the capacity of Chief Technical Officer at Nugenics Research exploring rejuvenation treatments in mammals.
In May 2020 there was a paper published on biorxiv about the rejuvenation of rats by over 50%. We did a review of the paper which you can find linked to above. In this interview series we talk with Dr. Harold Katcher, one of the main authors of the paper about the experiment, the steps to get validation, commercialization and how the results fit into his theories of aging.
Gearing up for the interview with Harold Katcher!
Epigenetic age reversed by 54%. Scientific trial by Horvath Clock.
Continue reading “Reverse Aging Over 54% Study | Horvath Clock” »
The international team of artificial intelligence experts and medical doctors propose a framework for the application of next-generation AI to extend human longevity.
Deep Longevity Ltd.
Mayo Clinic proof-of-concept study shows that removal of senescent cells in the hippocampus of mice leads to improved cognitive responses.
‘The Death of Death’ — David Wood and Jose Cordeiro.
“La mort de la mort — les avancées scientifiques vers l’immortalité” was published on 21st January 2021 and is available in bookshops throughout France, Belgium, Luxembourg, and Switzerland, as well as online — see e.g. https://www.amazon.fr/mort-avanc%C3%A9es-scientifiques-vers-…875422200/
Continue reading “Introducing La Mort de la Mort — English” »
Forever we have held a view that AGING, DISEASE & DEATH is an un-alterable eventuality, those who dared question were ostracised for playing God.
If you choose to look deeper you will surely be amazed. Bowhead whales live for over 200 yrs “Turriptosis Dohnri” is a Jellyfish that lives forever. Can these #genetics traits be replicated in humans? Could the removal of #senescence #cells that accelerates aging be the answer Is it even possible to control or reverse aging? Can we grow old healthily? 150000 die every day & over 100000 of them are caused by aging.
Fair to say that we all assume that aging is inevitable. In reality however, there is no biological law that says we must age. Over the years we’ve seen a variety of theories proposed to explain why we age including the accumulation of damage to our DNA, the damaging effects of chemicals called “free radicals, changes in the function of our mitochondria, and so many others.
Our guest today, Dr. David Sinclair, believes that aging is related to a breakdown of information. Specifically, he describes how, with time, our epigenome accumulates changes that have powerful downstream effects on the way our DNA functions. Reducing these changes to the epigenome is achievable and in fact, even taking it further, his research now reveals that the epigenome can be reprogrammed back to a youthful state.
Continue reading “The Empowering Neurologist — David Perlmutter M.D., and Dr. David Sinclair” »
A team of scientists from the Leibniz Institute for Zoo and Wildlife Research (Leibniz-IZW) inGermany, Givskud Zoo–Zootopia in Denmark and the University of Milan in Italy succeeded in producing the very first African lionin-vitroembryos after the vitrification of immature oocytes. For this specific method of cryopreservation, oocytes are collected directly after an animal is castrated or deceased and immediately frozen at-196°C in liquid nitrogen. This technique allows the storage of oocytes of valuable animals for an unlimited time, so that they can be used to produce offspring with the help of assisted reproduction techniques. The aim is to further improve and apply these methods to save highly endangered species such as the Asiatic lion from extinction. The current research on African lions as a model species is an important step in this direction. The results are reported in the scientific journal Cryobiology.
Lion oocytes are presumed to be very sensitive to chilling due to their high lipid content, resulting in poor revival following slow cooling. Vitrification can circumvent this problem, as the cells are frozen at ultra-fast speeds in solutions with a very high concentration of cryoprotective agents. This method prevents the formation of ice crystals in the cells, which could destroy them, and enables them to remain intact for an unlimited time to allow their use later on.
For the present research, the scientists collected oocytes from four African lionesses from Givskud Zoo—Zootopia after the animals had been euthanised for the purpose of population management. Half of the oocytes (60) were vitrified instantly. After six days of storage in liquid nitrogen, the vitrified oocytes were thawed and subjected toin-vitromaturation in an incubator at 39°C for a total of 32–34 hours. The other half (59) were used as control group and directly subjected toin-vitromaturation without a step of vitrification. Mature oocytes of both groups were then fertilized with frozen-thawed sperm from African lion males. “We could demonstrate a high proportion of surviving and matured oocytes in the group of vitrified oocytes. Almost 50% of them had matured, a proportion similar to that in the control group,” says Jennifer Zahmel, scientist at the Department of Reproduction Biology at the Leibniz-IZW.
