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Category: life extension – Page 267

Short term treatment with a cocktail of rapamycin, acarbose and phenylbutyrate delays aging phenotypes in mice

Pharmaceutical intervention of aging requires targeting multiple pathways, thus there is rationale to test combinations of drugs targeting different but overlapping processes. In order to determine if combining drugs shown to extend lifespan and healthy aging in mice would have greater impact than any individual drug, a cocktail diet containing 14 ppm rapamycin, 1,000 ppm acarbose, and 1,000 ppm phenylbutyrate was fed to 20-month-old C57BL/6 and HET3 4-way cross mice of both sexes for three months. Mice treated with the cocktail showed a sex and strain-dependent phenotype consistent with healthy aging including decreased body fat, improved cognition, increased strength and endurance, and decreased age-related pathology compared to mice treated with individual drugs or control. The severity of age-related lesions in heart, lungs, liver, and kidney was consistently decreased in mice treated with the cocktail compared to mice treated with individual drugs or control, suggesting an interactive advantage of the three drugs. This study shows that a combination of three drugs, each previously shown to enhance lifespan and health span in mice, is able to delay aging phenotypes in middle-aged mice more effectively than any individual drug in the cocktail over a 3-month treatment period.

© 2022. The Author(s).

Conflict of interest statement.

On Longevity Escape Velocity with Aubrey de Grey & Charles Brenner

For our inaugural episode of Let’s Talk Longevity, we want to figure out if we are anywhere near Longevity Escape Velocity. Defined as a hypothetical situation in which life expectancy is extended longer than the time that is passing, we decided the best conversation on it would be with its biggest advocate, Dr. Aubrey de Grey, and an equally well-known skeptic of the likelihood of it taking place, Dr. Charles Brenner. This debate did not need hosts!

Join us for the live Q&A on Twitter Spaces this Thursday, May 12th at 12 pm PDT
https://twitter.com/i/spaces/1ypKdEmgDANGW

Also available on Apple Podcasts:
https://podcasts.apple.com/us/podcast/lets-talk-longevity/id1623103254

Our sponsors.
Methuselah Foundation https://www.mfoundation.org/
The Methuselah Foundation is a non-profit medical charity focused on extending the healthy human lifespan by making 90 the new 50 by 2030.

MYKIGAI: https://mykigai.substack.com/letstalklongevity.
Discovery & Recommendation platform for longevity.

Social & Website.

Continue reading “On Longevity Escape Velocity with Aubrey de Grey & Charles Brenner” | >

Cryostasis Revival: The Recovery of Cryonics Patients through Nanomedicine

Cryostasis Revival by Robert Freitas is the first comprehensive technical exposition how to revive cryonics patients in the future. This 700+ page book with thousands of references, and technical color illustrations, is now available on Amazon in a limited textbook hardcover edition.

Cryostasis is an emergency medical procedure in which a human patient is placed in biological stasis at cryogenic temperatures. A cryopreserved patient can be maintained in this condition indefinitely without suffering additional degradation, but cannot yet be revived using currently available technology. This book presents the first comprehensive conceptual protocol for revival from human cryopreservation, using medical nanorobots. The revival methods presented in this book involve three stages: collecting information from preserved structure, computing how to fix damaged structure, and implementing the repair procedure using nanorobots manufactured in a nanofactory – a system for atomically precise manufacturing that is now visible on the technological horizon.

Sirtuin 6 : Summary Of Key Points of Professor Cohen Interview | Modern Healthspan

There is a SIRT6 activator on the market but it is very expensive at a few hundred dollars.

We have had requests for a summary of the interview with Prof Cohen. This video is a summary of the key points from the interviews. As I note in the introduction, this is my interpretation of what Prof Cohen said, please check the original interviews if you have any questions. And please do feel free to let me know if you think I got something wrong!

Professor Haim Cohen is the director of the Sagol Healthy Human Longevity Center at Bar-Ilan University where he focuses much of his research on the SIRT6 protein. In May 2021 he and his team published a paper showing a 30% increase in lifespan in a mouse model by over expressing SIRT6.

Prof Cohen’s page at the university.
https://life-sciences.biu.ac.il/en/node/641
Prof Cohen’s Lab.
https://www.haimcohenlab.com/

Prof Cohen’s Paper on Sirt6 is here.

Continue reading “Sirtuin 6 : Summary Of Key Points of Professor Cohen Interview | Modern Healthspan” | >

Longevity Research is an Economic Necessity

It is vital to recognize the immediate economic importance of i nvesting in longevity and healthy-aging sciences.

Aging itself is a complex series of at least 300 biological processes involving more than 10% of our genetic makeup. It follows that methods to combat these effects must be a combination of sciences, from biotech to biophysics and pharmaceuticals. There is no single “silver bullet” solution.

Aging, along with the physical and mental decay that accompanies it, is still widely regarded as a natural and inevitable thing. It is not, it is a degenerative disease in which the physical integrity and structure of our cells decay each time they divide to replace old ones or as part of any healing process.

Blood Test Analysis: Italian Centenarians

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https://www.patreon.com/MichaelLustgartenPhD

Biomarker timestamps:
Glucose 1:37
HDL 2:43
Triglycerides 4:10
RBCs, Hemoglobin 5:29
Platelets 7:16
Uric Acid 8:37
AST, ALT 11:04
Total Cholesterol 13:55
WBCs 15:47
Total Protein, Albumin, Globulin 17:38
Creatinine 21:27
BUN 22:35

Papers referenced in the video:
Laboratory parameters in centenarians of Italian ancestry.
https://pubmed.ncbi.nlm.nih.gov/17681733/

Risk Factors For Hyperuricemia In Chinese Centenarians And Near-Centenarians.
https://pubmed.ncbi.nlm.nih.gov/31908434/

Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort study.
https://pubmed.ncbi.nlm.nih.gov/32623847/

High-density lipoprotein cholesterol and all-cause mortality by sex and age: a prospective cohort study among 15.8 million adults.

Continue reading “Blood Test Analysis: Italian Centenarians” | >

2022 Conference

This year, the Alcor Life Extension Foundation is celebrating its 50th year. To mark the occasion, we are holding a conference on June 3–5, 2022, at the Scottsdale Resort in Scottsdale, Arizona.

The conference itself will be Alcor’s first major in-person gathering in seven years, so we’re going to “go big.” We expect members, prospective members, and others interested in life extension and the far future to turn out enthusiastically. We hope not only that our attendees will enjoy hearing from and interacting with you, but also that you may find the experience enjoyable. There is no organization quite like Alcor, after all, and very few opportunities to explore cryonics and its implications for society now and in the far future.

Dr. Pat Verduin, PhD — Chief Technology Officer — Colgate-Palmolive — Reimagining A Healthier Future

Reimagining A Healthier Future for All — Dr. Pat Verduin PhD, Chief Technology Officer, Colgate, discussing the microbiome, skin and oral care, and healthy aging from a CPG perspective.

Dr. Patricia Verduin, PhD, (https://www.colgatepalmolive.com/en-us/snippet/2021/circle-c…ia-verduin) is Chief Technology Officer for the Colgate-Palmolive Company where she provides leadership for product innovation, clinical science and long-term research and development across their Global Technology Centers’ Research & Development pipeline.

Dr. Verduin joined Colgate Palmolive in 2007 as Vice President, Global R&D. Previously she served as Vice President, Scientific Affairs, for the Grocery Manufacturers Association, and from 2000 to 2006, she held the position of Vice President, Research & Development, at ConAgra Foods.

Dr. Verduin started her career with 17 years at Nabisco, serving in multiple roles, including plant manager and scientist. She earned her undergraduate degree from the University of Delaware, holds an MBA from Fairleigh Dickinson University and a PhD in Food Science from Rutgers University.

Colgate-Palmolive Company (https://www.colgatepalmolive.com/) is an American multinational consumer products company specializing in the production, distribution and provision of household, health care, personal care and veterinary products, with a mission of re-imagining a healthier future for all people, their pets and our planet.

Continue reading “Dr. Pat Verduin, PhD — Chief Technology Officer — Colgate-Palmolive — Reimagining A Healthier Future” | >

The long and gruesome history of people trying to live forever

Estimates put this industry’s worth at a staggering $610 billion by 2025. 😳

The Renaissance philosopher Montaigne quipped that “death has us by the scruff of the neck at every moment.” He could have added: until, finally, it strangles us. But what if we knew how to escape death’s chokehold? What if we could avoid death and live forever?

Immortality might seem like the stuff of science fiction, yet it’s increasingly becoming the focus of real science. In 2013, Google launched Calico, a biotech firm whose objective is to “solve” death. PayPal co-founder Peter Thiel, meanwhile, has pledged to “fight” death. And last year, it was reported Amazon chairman Jeff Bezos had invested in Altos Labs, a company that plans to “rejuvenate” cells in order to “reverse disease.” (Bezos owns The Washington Post.)

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