Lifeboat Foundation

CRISPR gene editing created the G795A amino acid which was introduced to microglia derived from human stem cells. Researchers were able to transplant the donor microglia immune cells into humanized rodent models while administering an FDA-approved cancer drug called pexidartinib. The inclusion of the amino acid cause the donated microglia to thrive and resist the drug, while the host microglia died. The findings open the door for new methods of using microglia to treat a range of neurodegenerative disorders.

Scientists have detected bits of adenine, guanine and other organic compounds in meteorites since the 1960s (SN: 8/10/11, SN: 12/4/20). Researchers have also seen hints of uracil, but cytosine and thymine remained elusive, until now.

“We’ve completed the set of all the bases found in DNA and RNA and life on Earth, and they’re present in meteorites,” says astrochemist Daniel Glavin of NASA’s Goddard Space Flight Center in Greenbelt, Md.

A few years ago, geochemist Yasuhiro Oba of Hokkaido University in Sapporo, Japan, and colleagues came up with a technique to gently extract and separate different chemical compounds in liquified meteorite dust and then analyze them.

In a recent study published in Scientific Reports, researchers identified serological Hepatitis C virus (HCV) signatures and human immunodeficiency virus (HIV) signatures through the secondary utilization of ribonucleic acid sequencing (RNA-seq) analysis data among previous and existing smokers with or without COPD (chronic obstructive pulmonary disease).

Viral detection by RNA sequencing analysis has increased the knowledge base of viruses causing human infections. Identifying undiagnosed viral infections by using existing nucleic acid sequencing data could facilitate epidemiological survey-based analysis and aid in the development of diagnostic and therapeutic options for improved population health.

Serotonin can impact the mitral valve of the heart and potentially accelerate a cardiac condition known as degenerative mitral regurgitation, according to a new study led by researchers at Columbia University.

Columbia University is a private Ivy League research university in New York City that was established in 1754. This makes it the oldest institution of higher education in New York and the fifth-oldest in the United States. It is often just referred to as Columbia, but its official name is Columbia University in the City of New York.

The study examined the impact of celecoxib and indomethacin, two types of non-steroidal anti-inflammatory drugs (NSAIDs) classified by the World Health Organization (WHO) as the initial level of pain relief medication, along with paracetamol.

According to a study conducted by the University of São Paulo in Brazil, which was published in the journal Scientific Reports.

Established in 2011, <em>Scientific Report</em>s is a peer-reviewed open-access scientific mega journal published by Nature Portfolio, covering all areas of the natural sciences. In September 2016, it became the largest journal in the world by number of articles, overtaking <em>PLOS ON</em>E.

Chinese scientists in a 10-year study found that people who adhered to the special six rules, the risk of dementia decreased by 90%. Even with a genetic predisposition to Alzheimer’s disease. The study involved 29 thousand people over 60 years of age, who were divided into three groups.

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These scientists seem to be enjoying themselves. 🤣

They just want stronger more disease free fish.

The resulting fish appear to be more resistant to disease and could improve commercial production—should they ever be approved.

😉

Persons with autism spectrum conditions (ASC) often engage in video gaming, one of the most common leisure activity in this population. Escapism, aimed at the avoidance of negative experiences or self-development, is considered as one of the main gaming motivations. Furthermore, escapism is a self-regulatory strategy used while suffering from autistic burnout, consisting of exhaustion, reduced social skills, anhedonia, and withdrawal. The goal of the current study was to determine predictors of escapism in video gaming among adult gamers with ASC. It was hypothesized that two types of escapism – self-suppression and self-expansion – would differentiate gaming motivations, affective outcomes, anhedonia, and autistic burnout rates. A total of 189 persons participated in the study (M_age = 27.52, SD_age = 7.25), including 105 females. The results obtained indicated that self-suppression escapism was predicted by introjected regulation, positive and negative affect, and hedonic tone (F = 8.760, p < .001), while self-expansion was predicted by identified and integrated gaming motivations, hedonic tone, and positive affect (F = 23.066, p < .001). PLS-SEM analysis revealed good fit of the model with autistic burnout predicting self-suppression escapism. These results acknowledge the two-dimensional approach to escapism and highlight potential risk factors of self-suppression, especially among persons presenting symptoms of autistic burnout. Future research and clinical application directions are outlined.