Lifeboat Foundation

Year 2014 Essentially this could scan blood very quickly compared to older outdated methods with mass spectrometry.

Rapid identification of the causative microorganism is important for appropriate antimicrobial therapy of bloodstream infections. Bacteria from positive blood culture (BC) bottles are not readily available for identification by matrix-assisted laser desorption ionization—time of flight mass spectrometry (MALDI-TOF MS). Lysis and centrifugation procedures suggested for direct MALDI-TOF MS from positive BCs without previous culture are associated with additional hands-on processing time and costs. Here, we describe an alternative approach applying MALDI-TOF MS from bacterial cultures incubated very briefly on solid medium. After plating of positive BC broth on Columbia blood agar (n = 165), MALDI-TOF MS was performed after 1.5, 2, 3, 4, 5, 6, 7, 8, 12 and (for control) 24 h of incubation until reliable identification to the species level was achieved (score ≥2.0). Mean incubation time needed to achieve species-level identification was 5.9 and 2.0 h for Gram-positive aerobic cocci (GPC, n = 86) and Gram-negative aerobic rods (GNR, n = 42), respectively. Short agar cultures with incubation times ≤2, ≤4, ≤6, ≤8 and ≤12 h yielded species identification in 1.2%, 18.6%, 64.0%, 96.5%, 98.8% of GPC, and in 76.2%, 95.2%, 97.6%, 97.6%, 97.6% of GNR, respectively. Control species identification at 24 h was achieved in 100% of GPC and 97.6% of GNR. Ethanol/formic acid protein extraction performed for an additional 34 GPC isolates cultivated from positive BCs showed further reduction in time to species identification (3.1 h). MALDI-TOF MS using biomass subsequent to very short-term incubation on solid medium allows very early and reliable bacterial identification from positive BCs without additional time and cost expenditure.

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Mycoplasma pneumoniae are tiny bacteria typically known to cause lung infections. But now, a group of scientists have turned them into double agents. Genetically engineered Mycoplasma helped break down biofilms of another pathogenic microbe, Pseudomonas aeruginosa, in a mouse model of ventilator-associated pneumonia and on tube samples taken from human patients, the team reported January 19 in Nature Biotechnology. It is one of the first times that scientists have used live bacteria to treat a lung disease, and is the first therapeutic use of Mycoplasma.

“This approach is really powerful,” says Dave Hava, a microbiologist who wasn’t involved in the research, but who works at a company called Synlogic that develops live bacteria therapeutics for gut issues. “It offers the chance to target diseases and mechanisms that you can’t do with conventional therapies.”

Biological and chemical weapons have the potential to pose a national security threat to the U.S. that the country is not equipped to handle, a panel of lawmakers and a military leader told an audience at the Aspen Security Forum.

https://www.youtube.com/watch?v=NKrnoJ4hpLs

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Welcome to Futureunity, where we explore the fascinating world of science, technology, and the universe! From the inner workings of the human body to the outer reaches of space, we delve into the latest and most interesting discoveries that are shaping our world. Whether you’re a science buff or just looking for some mind-blowing facts, we’ve got you covered. Join us as we uncover the mysteries of the world around us and discover new frontiers in the fields of science and technology. Get ready for a journey that’s both educational and entertaining!

Continue reading “Scientists Have Announced That 7 Mysterious Cosmic Objects Keep Passing Through The Solar System” »

Nearly 15,500 people in the U.S. over age 50 are estimated to have VEXAS syndrome.

A rare disorder called VEXAS syndrome has bemused the United States’ health services since 2020. The syndrome was a great mystery until the researchers’ work yielded results.

As stated by NYU Langone Health, with up to 50 percent of sufferers, mostly men, passing away within five years of diagnosis, this illness has a significant mortality rate.

Continue reading “VEXAS: Mysterious disease with high mortality rate detailed in study” »

The technology can detect disorders up to six months earlier than a doctor.

Researchers are using motion capture artificial intelligence technology that brings characters to life in films like Avatar to track the onset of diseases which affect movement, according to a report by the BBC

Continue reading “Researchers use Avatar’s motion AI tech to track rare diseases” »

Whether we realize it or not, cryptography is the fundamental building block on which our digital lives are based. Without sufficient cryptography and the inherent trust that it engenders, every aspect of the digital human condition we know and rely on today would never have come to fruition much less continue to evolve at its current staggering pace. The internet, digital signatures, critical infrastructure, financial systems and even the remote work that helped the world limp along during the recent global pandemic all rely on one critical assumption – that the current encryption employed today is unbreakable by even the most powerful computers in existence. But what if that assumption was not only challenged but realistically compromised?

This is exactly what happened when Peter Shor proposed his algorithm in 1995, dubbed Shor’s Algorithm. The key to unlocking the encryption on which today’s digital security relies is in finding the prime factors of large integers. While factoring is relatively simple with small integers that have only a few digits, factoring integers that have thousands of digits or more is another matter altogether. Shor proposed a polynomial-time quantum algorithm to solve this factoring problem. I’ll leave it to the more qualified mathematicians to explain the theory behind this algorithm but suffice it to say that when coupled with a quantum computer, Shor’s Algorithm drastically reduces the time it would take to factor these larger integers by multiple orders of magnitude.

Prior to Shor’s Algorithm, for example, the most powerful computer today would take millions of years to find the prime factors of a 2048-bit composite integer. Without Shor’s algorithm, even quantum computers would take such an inordinate amount of time to accomplish the task as to render it unusable by bad actors. With Shor’s Algorithm, this same factoring can potentially be accomplished in a matter of hours.

Didn’t they just have record-breaking profits?

There’s an eerie similarity to the statements tech companies have made about their recent layoffs. Mainly, if the press releases are to be believed, the C-suite of every Big Tech company on Earth — well, with the notable exception of Apple, which has not announced layoffs — figured no one would ever go outside or spend money offline again after the pandemic and their various online businesses would stay just as big as they were during the heights of covid.

I do love a heavily lawyered statement that was clearly written by the public relations department! In fact, these are all so similar that they might as well have come from the same PR person… More.

Continue reading “Why are so many tech companies laying people off right now?” »

More than one-third of UK health experts are not aware of Charles Bonnet syndrome — CBS — a condition which can cause vivid, and sometimes frightening, hallucinations.

A poll of 1,100 health experts — including GPs, doctors and optometrists — found 37 per cent were not aware of CBS.

The condition is not caused by mental health problems or dementia. It is purely due to a loss of sight — 60 per cent or more — which reduces or stops the regular messages from the eye to the brain.