Lifeboat Foundation

Targeting calcium signaling in neurons represents a promising therapeutic approach for treating a rare form of schizophrenia, according to a Northwestern Medicine study published in Biological Psychiatry.

“This is the first time that human neurons are made and characterized from schizophrenia patients with the 16p11.2 duplication, one of the most prominent genetic risk factors in schizophrenia, and the first time that calcium signaling is found as a central abnormality in schizophrenia neurons,” said Peter Penzes, Ph.D., the Ruth and Evelyn Dunbar Professor of Psychiatry and Behavioral Sciences and senior author of the study.

Schizophrenia is characterized by auditory and visual hallucinations, delusions, and trouble with forming and sorting thoughts, which severely impacts productivity and overall quality of life. The disease, which affects roughly one percent of the general population, has strong genetic associations, however the exact genes involved are unknown.

This is a talk given to the Department of Biotechnology at Indian Institute of Technology Madras in January 2023.

A 3D mesh is a three-dimensional object representation made of different vertices and polygons. These representations can be very useful for numerous technological applications, including computer vision, virtual reality (VR) and augmented reality (AR) systems.

Researchers at Florida State University and Rutgers University have recently developed Wi-Mesh, a system that can create reliable 3D human meshes, representations of humans that can then be used by different computational models and applications. Their system was presented at the Twentieth ACM Conference on Embedded Networked Sensor Systems (ACM SenSys ‘22), a conference focusing on computer science research.

“Our research group specializes in cutting-edge wi-fi sensing research,” Professor Jie Yang at Florida State University, one of the researchers who carried out the study, told Tech Xplore. “In previous work, we have developed systems that use wi-fi devices to sense a range of human activities and objects, including large-scale human body movements, small-scale finger movements, sleep monitoring, and daily objects. Our E-eyes and WiFinger systems were among the first to use wi-fi sensing to classify various types of daily activities and finger gestures, with a focus on predefined activities using a trained model.”

A Quebec hospital adopts a novel use of VR to help patients with anxiety, phobias and pain.

In a newswire release today, the Fondation de l’Hôtel-Dieu d’Alma (the Alma Hospital Foundation) announced the launch of a virtual reality (VR) project aimed at improving the mental health of those experiencing increasing anxiety. The Alma Hospital is a regional health centre for the area of Lac St. Jean and the Saguenay River valley to the north of Quebec City.

Jean Lamoureux, the hospital’s Executive Director states, “The number of requests for mental-health consultations is estimated to have increased by 30 to 40 percent during the pandemic. These needs are urgent…and, thanks to the innovation of Paperplane Therapeutics and TELUS, we will transform the way health services are delivered, while having a significant positive impact on patient well-being through technology.”

Continue reading “Quebec Hospital Using Virtual Reality to Address Increasing Mental Health Issues from the Pandemic” »

Human civilization has achieved some incredible things during its short reign on this planet. Technological development over the past 5,000 years of human civilization has led our species to dominance of life on Earth and placed us on a pathway to achieving a Type I civilization.

To reach even the basic level of a “Kardashev Type 1 civilization” we must do two things:
Develop more advanced technology and share it with all responsible nations.
Make renewable energy accessible to all parts of the world.

Continue reading “The Power Source of The Universe — Can Nuclear Fusion Help us Reach Type 1 Civilization?” »

Very old brain, some ancient philosophy maybe…

A fossilised fish originally dug up more than a century ago in an English coal mine has been shown to hold the world’s oldest brain in a vertebrate animal.

CT scans revealed the new internal features including a brain and cranial nerves about 2 centimetres long.

Continue reading “Oldest brain in a backboned animal found in fish fossil” »

Engineers at the University of Waterloo have developed artificial intelligence (AI) technology to predict if women with breast cancer would benefit from chemotherapy prior to surgery.

The new AI algorithm, part of the open-source Cancer-Net initiative led by Dr. Alexander Wong, could help unsuitable candidates avoid the serious side effects of chemotherapy and pave the way for better surgical outcomes for those who are suitable.

“Determining the right treatment for a given breast cancer patient is very difficult right now, and it is crucial to avoid unnecessary side effects from using treatments that are unlikely to have real benefit for that patient,” said Wong, a professor of systems design engineering.

Advancing Geroscience & Gerotherapeutics — Dr. Nir Barzilai, MD, Albert Einstein College of Medicine.

Dr. Nir Barzilai, MD (https://www.einsteinmed.edu/faculty/484/nir-barzilai/) is the Director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. He is the Ingeborg and Ira Leon Rennert Chair of Aging Research, professor in the Departments of Medicine and Genetics, and member of the Diabetes Research Center and of the Divisions of Endocrinology & Diabetes and Geriatrics.

Continue reading “Dr Nir Barzilai, MD — Advancing Geroscience & Gerotherapeutics — Albert Einstein College of Medicine” »

Arizona State University has officially begun a new chapter in X-ray science with a newly commissioned, first-of-its-kind instrument that will help scientists see deeper into matter and living things. The device, called the compact X-ray light source (CXLS), marked a major milestone in its operations as ASU scientists generated its first X-rays on the night of Feb. 2.

“This marks the beginning of a new era of science with compact accelerator-based X‑ray sources,” said Robert Kaindl, who directs ASU’s Compact X-ray Free Electron Laser (CXFEL) Labs at the Biodesign Institute and is a professor in the Department of Physics. “The CXLS provides hard X-ray pulses with high flux, stability and ultrashort durations, in a very compact footprint. This way, matter can be resolved at its fundamental scales in space and time, enabling new discoveries across many fields — from next-generation materials for computing and information science, to renewable energy, biomolecular dynamics, drug discovery and human health.”

Building the compact X-ray light source is the first phase of a larger CXFEL project, which aims to build two instruments including a coherent X-ray laser. As the first-stage instrument, the ASU CXLS generates a high-flux beam of hard X‑rays, with wavelengths short enough to resolve the atomic structure of complex molecules. Moreover, its output is pulsed at extremely short durations of a few hundred femtoseconds — well below a millionth of one millionth of a second — and thus short enough to directly track the motions of atoms.