Lifeboat Foundation

The journal club will be returning on 27th August with your host Dr. Oliver Medvedik and special guest Alexander Tyshkovskiy, a Ph.D. student who works at the Gladyshev Lab at Brigham and Women’s Hospital, Harvard Medical School, Boston. The topic for the journal club this month will be the recent paper, “Identification and Application of Gene Expression Signatures Associated with Lifespan Extension” published in Cell Metabolism. This study is Alexander Tyshkovskiys project and forms part of his Ph.D. so we are fortunate to have him joining us on the show to talk us through this fascinating study.

Sci-Hub link here: https://sci-hub.tw/https://www.sciencedirect.com/science/art…3119303729

In a recent study, a team from the Neurobiota Research Center in Korea has discovered that reducing gut dysbiosis partially alleviates the cognitive impairment associated with Alzheimer’s disease. This may seem puzzling, as the gut and the brain are separate and relatively distant organs, but this research makes sense in the context of chronic inflammation.

Inflammaging

Under normal circumstances, inflammation is a short-term measure in response to infection: immune cells are directed towards the inflamed area and handle the infection, and then the inflammation dies down. However, chronic inflammation causes harm to our organs; it is the main form of altered intercellular communication, which is one of the hallmarks of aging. The protein complex NF-kB, the master regulator of inflammation, is the main culprit of inflammaging, and it is specifically discussed in this paper.

According to the latest #research in regenerative #medicine this is no longer science fiction but will come true in the foreseeable future.

Aren Jay shared this cogent article to my Timeline… It is not new even Hippocrates was able to determine that the gut causes and or assists in all diseases. But the 19th and 20th centuries researchers began saying that microbes are good for mankind which sent science reeling through generations until this day… Respect r.p.berry & AEWR wherein we have developed a formula and Algorithm that deals with this very serious problem completely. A very expensive cure but one that will take Woman-Man past the Escape Velocity so many have written about… https://gerevivify.blogspot.com/

Recent research has found that bacteria in the gut can affect people’s mental state, leading to mood, cognition and behavioural problems. But in TCM, the link between the gut and all of the body’s organs has long been recognised.

Dubbed ‘antibiotic apocalypse’, the antibiotic resistant superbugs have become a massive cause for concern for health professionals as their numbers continue to rise. Such is the worry around antibiotic superbugs that experts believe that they will claim 10 million lives by 2050, with 700,000 people dying a year after catching the infections, according to a recent report from the American Chemical Society’s Enviromental Science and Technology Journal. Humans, especially in the West, have become so reliant on antibiotics to help cure illnesses that many of the bacteria that they are trying to fight have become resistant to the drugs through evolution.

Chemotherapy works off of a basic premise: kill all rapidly-growing cells in an effort to wipe out tumor cells. The tactic, while generally effective, has quite a few off-target casualties, including cells that produce hair and cells that line the stomach.

Scientists have tried to skirt the problem by creating missile-like drugs that zero in on cancer cells specifically, sparing healthy cells.

These missile-like drugs, known as antibody-drug conjugates (ADCs), have been in the works for decades, but only in recent years have they made it to clinical trials, Kimberly Tsui, a genetics graduate student, told me.

Industry declares that it will not make DNA changes affecting future generations.

We learn from our personal interaction with the world, and our memories of those experiences help guide our behaviors. Experience and memory are inexorably linked, or at least they seemed to be before a recent report on the formation of completely artificial memories. Using laboratory animals, investigators reverse engineered a specific natural memory by mapped the brain circuits underlying its formation. They then “trained” another animal by stimulating brain cells in the pattern of the natural memory. Doing so created an artificial memory that was retained and recalled in a manner indistinguishable from a natural one.

Memories are essential to the sense of identity that emerges from the narrative of personal experience. This study is remarkable because it demonstrates that by manipulating specific circuits in the brain, memories can be separated from that narrative and formed in the complete absence of real experience. The work shows that brain circuits that normally respond to specific experiences can be artificially stimulated and linked together in an artificial memory. That memory can be elicited by the appropriate sensory cues in the real environment. The research provides some fundamental understanding of how memories are formed in the brain and is part of a burgeoning science of memory manipulation that includes the transfer, prosthetic enhancement and erasure of memory. These efforts could have a tremendous impact on a wide range of individuals, from those struggling with memory impairments to those enduring traumatic memories, and they also have broad social and ethical implications.

In the recent study, the natural memory was formed by training mice to associate a specific odor (cherry blossoms) with a foot shock, which they learned to avoid by passing down a rectangular test chamber to another end that was infused with a different odor (caraway). The caraway scent came from a chemical called carvone, while the cherry blossom scent came from another chemical, acetophenone. The researchers found that acetophenone activates a specific type of receptor on a discrete type of olfactory sensory nerve cell.

Saying goodbye to the warm summer months is a little easier when it also means the war against mosquito bites is coming to an end. They’re not just an itchy annoyance, however, mosquitoes can spread dangerous diseases and viruses, but researchers at Brown University might have come up with the perfect mosquito forcefield: garments lined with graphene.