Lifeboat Foundation

A new study by the Yale scientists, taking insulin or the most commonly used drug for type 2 diabetes, metformin, failed to either delay or effectively treat the condition in youth.

In the study, dubbed as Restoring Insulin Secretion (RISE) Pediatric Medication Study, scientists explored the impact of two medications for pre-diabetes or diabetes in youth aged 10 to 19. The children and teens either took infusions of insulin for three months, trailed by metformin for a year, or metformin alone. Amid the 15-month contemplate period, the analysts surveyed glucose levels of study members and also the capacity of their beta cells, which store and discharge insulin keeping in mind the end goal to keep up solid glucose.

Scientists discovered that the medications neglected to moderate or stop the progression of type 2 diabetes in either group. The working of the adolescents’ beta cells kept on breaking down in spite of the treatments, which have been appealed to treat write 2 diabetes adequately in adults.

Continue reading “Standard type 2 diabetes treatments may not improve the condition in youth” »

Did you feel it?

Billy Dee Williams, who played the galactic gambler Lando Calrissian, will reprise the role for ‘Star Wars: Episode IX,’ the next installment from Lucasfilm.

Bucknell has led advanced engineering teams at Chrysler and General Motors for three production high performance engine families. Was Senior Propulsion Engineer for the Raptor full-flow staged combustion methalox rocket at Space Exploration Technologies then Senior Propulsion Scientist for Divergent3D developing vehicle technologies.

In 2017, he described how high temperature (820−1000 degree celsius) nuclear power plants can solve produce synthetic fuel to replace oil.

Continue reading “Turbo inductor cogeneration with MSR nuclear can economically replace oil” »

Experiments to confirm we can see single photons offer new ways to probe our understanding of quantum reality.

• By Anil Ananthaswamy on July 10, 2018

Soaring global need for cooling by 2050 could see world energy consumption for cooling increase five times as the number of cooling appliances quadruples to 14 billion—according to a new report by the University of Birmingham, UK.

This new report sets out to provide, for the first time, an indication of the scale of the energy implications of ‘Cooling for All’.

Effective cooling is essential to preserve food and medicine. It underpins industry and economic growth, is key to sustainable urbanisation as well as providing a ladder out of rural poverty. With significant areas of the world projected to experience temperature rises that place them beyond those which humans can survive, cooling will increasingly make much of the world bearable—or even safe—to live in. With populations increasing, expanding urbanisation and climate change impacts leading to more frequent heatwaves and temperature rises, the demand for more cooling will increase in the decades ahead.

Continue reading “Global quadrupling of cooling appliances to 14 billion by 2050” »

Researchers isolated several mutations leading to melanoma and reproduced them in the lab using CRISPR.

Two papers authored by researchers at the University of California, San Francisco described the genetic changes that turn harmless moles into malignant melanomas and the experiment they devised to recreate the step-by-step evolution of normal skin cells into cancer cells [1], [2].

Summary ([1])

Continue reading “Two Papers Trace The Steps Leading From Moles to Melanomas” »

We wanted to draw your attention to a new publication by James Kirkland and his team. Kirkland is one of the pioneers of senolytics, as he demonstrated that a combination of compounds could remove senescent cells and improve healthspan in mice back in 2015 [1].

The contribution of senescent cells to aging has been the subject of intense research in the last year or two, as researchers have focused on ways to remove these problem cells using therapies known as senolytics.

Do you want to join in the fight to end age-related disease?

Request for Proposals (RFP)

In cooperation with the Forever Healthy Foundation, SENS Research Foundation (SRF) is inviting candidates to submit research proposals for a Fellowship in Rejuvenation Biotechnology that would be undertaken at our Research Center (RC) in Mountain View, California.

SRF pursues the development of therapies to prevent and reverse age-related disease and disability through a “damage-repair” paradigm: developing interventions that maintain and restore the structural and functional integrity of tissues by directly removing, repairing, replacing, or rendering harmless the cellular and molecular damage of aging. Applications are requested that promise progress in regenerative medicine for the prevention and reversal of age-related disease.

Continue reading “The Forever Healthy Foundation Fellowship in Rejuvenation Biotechnology” »

Researchers used magnetically driven microrobots to carry cells to predetermined spots within living zebrafish and mice, they report in Science Robotics today (June 27). The authors propose using these hair-width gadgets as delivery vehicles in regenerative medicine and cell therapy.

The scientists used a computer model to work out the ideal dimensions for a microrobot; spiky, porous, spherical ones were deemed best for transporting living cells. They printed the devices using a 3D laser printer and coated the bots with nickel and titanium to make them magnetic and biocompatible, respectively. An external magnetic field applied to the animal then leads the microrobots.

To begin with, the research team tested the ability for the robots to transport cells through cell cultures, blood vessel–like microfluidic chips, and in vivo in zebrafish. Further, they used these microrobots to induce cancer at a specific location within mice by ferrying tumor cells to the spot. The team observed fluorescence at the target site as the labeled cancer cells proliferated.

Continue reading “Magnetic Microrobots Deliver Cells Into Living Animals” »