A class of drugs used to treat certain breast cancers could help fight lung cancers that have become resistant to targeted therapies, according to a study conducted in mice.
The study, published in the journal Cell Reports, found that lung tumours in mice caused by mutations in a gene called EGFR shrunk significantly when a protein called p110a was blocked.
Researchers in the field of quantum communication have recently made great strides, taking us closer to a perfectly secure method of communication.
For years, researchers struggled to find ways to amplify quantum signals, store large amounts of quantum data, and allow for more than two nodes in a quantum network. However, in the last two months, solutions to all three of these problems have been found using the bizarre properties of the quantum world, in particular quantum entanglement.
Now that these hurdles have been overcome, quantum networks and even a quantum internet seem like real possibilities.
Physics grappled with the question of whether space is absolute or relative for centuries, before deciding in favor of relativity. But, it is only in recent years that the brain sciences have begun to discuss a parallel set of questions. For many years now, absolute space has ruled neuroscience. In the visual system, for example, it has long been assumed that there are two channels of information flow.4 The first is the “what” channel, carrying information about the identity of objects that an animal sees. The second is the “where” channel, containing information about the absolute position of these objects. It was believed that the “what” channel contained no positional information at all. However, recent work has shown that while no information about the absolute position of an object is present in this channel, there is relative position information.5,6 This relative positional information is likely to be very important for object recognition.
The first pieces of the brain’s “inner GPS” started coming to light in 1970. In the laboratories of University College London, John O’Keefe and his student Jonathan Dostrovsky recorded the electrical activity of neurons in the hippocampus of freely moving rats. They found a group of neurons that increased their activity only when a rat found itself in a particular location. They called them “place cells.”
Building on these early findings, O’Keefe and his colleague Lynn Nadel proposed that the hippocampus contains an invariant representation of space that does not depend on mood or desire. They called this representation the “cognitive map.” In their view, all of the brain’s place cells together represent the entirety of an animal’s environment, and whichever place cell is active indicates its current location. In other words, the hippocampus is like a GPS. It tells you where you are on a map and that map remains the same whether you are hungry and looking for food or sleepy and looking for a bed. O’Keefe and Nadel suggested that the absolute position represented in the hippocampal place cells provides a mental framework that can be used by an animal to find its way in any situation—be that to find food or a bed.
Over the next 40 years, other researchers—including the husband and wife duo of Edvard and May-Britt Moser—produced support for the idea that the brain’s hippocampal circuitry acts like an inner GPS. In recognition of their pioneering work, O’Keefe and the Mosers were awarded the 2014 Nobel Prize in physiology or medicine. You’d think that this would mean that the role of the hippocampus in guiding an animal through space was solved.
Posted in space
Histology is used to identify structural details of tissue at the microscale in the pathology lab, but analyses remain two-dimensional (2D) as they are limited to the same plane. Nondestructive 3D technologies including X-ray micro and nano-computed tomography (nanoCT) have proven validity to understand anatomical structures, since they allow arbitrary viewing angles and 3D structural detail. However, low attenuation of soft tissue has hampered their application in the field of 3D virtual histology. In a recent study, now published on Scientific Reports, Mark Müller and colleagues at the Department of Physics and Bioengineering have developed a hematein-based X-ray staining method to specifically target cell nuclei, followed by demonstrations on a whole liver lobule of a mouse.
In a recent publication in Science, researchers at the University of Paderborn and the Fritz Haber Institute Berlin demonstrated their ability to observe electrons’ movements during a chemical reaction. Researchers have long studied the atomic-scale processes that govern chemical reactions, but were never before able to observe electron motions as they happened.
