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Archive for the ‘neuroscience’ category: Page 591

Mar 16, 2020

Brain-doping produced by your own body

Posted by in categories: biotech/medical, neuroscience

Erythropoietin, or Epo for short, is a notorious doping agent. It promotes the formation of red blood cells, leading thereby to enhanced physical performance — at least, that is what we have believed until now. However, as a growth factor, it also protects and regenerates nerve cells in the brain. Researchers at the Max Planck Institute of Experimental Medicine in Göttingen have now revealed how Epo achieves this effect. They have discovered that cognitive challenges trigger a slight oxygen deficit (termed ‘functional hypoxia’ by the researchers) in the brain’s nerve cells. This increases production of Epo and its receptors in the active nerve cells, stimulating neighbouring precursor cells to form new nerve cells and causing the nerve cells to connect to one another more effectively.

The growth factor erythropoietin is among others responsible for stimulating the production of red blood cells. In anaemia patients it promotes blood formation. It is also a highly potent substance used for illegal performance enhancement in sports.

“Administering Epo improves regeneration after a stroke (termed ‘neuroprotection’ or ‘neurogeneration’), reducing damage in the brain. Patients with mental health disorders such as schizophrenia, depression, bipolar disorder or multiple sclerosis who have been treated with Epo have shown a significant improvement in cognitive performance,” says Hannelore Ehrenreich of the Max Planck Institute of Experimental Medicine. Along with her colleagues, she has spent many years researching the role played by Epo in the brain.

Mar 15, 2020

Battelle-Led Team Wins DARPA Award to Develop Injectable, Bi-Directional Brain Computer Interface

Posted by in categories: biotech/medical, business, government, military, neuroscience, robotics/AI

Here’s an exciting concept that was actually first discussed in 1959 by Richard Feynman in an article entitled “There’s Plenty of Room at the Bottom”.

I am most interested in this technology for mind uploading.

“Battelle’s N3 concept for a minimally invasive neural interface system, called BrainSTORMS (Brain System to Transmit Or Receive Magnetoelectric Signals), involves the development of a novel nanotransducer that could be temporarily introduced into the body via injection and then directed to a specific area of the brain to help complete a task through communication with a helmet-based transceiver.”

Continue reading “Battelle-Led Team Wins DARPA Award to Develop Injectable, Bi-Directional Brain Computer Interface” »

Mar 15, 2020

Scientists find toolkit to aid repair of damaged DNA

Posted by in categories: biotech/medical, life extension, neuroscience

March 9 (UPI) — Scientists have developed a technique for repairing damaged DNA. The breakthrough, published this week in the journal Nature Communications, could pave the way for new therapies for cancer and neurodegenerative disorders.

The accumulation of DNA damage is responsible for aging, cancer and neurological diseases like motor neuron disease, also known as ALS.

Until now, scientists have struggled to find ways to repair this kind of damage. However, researchers have discovered a new protein called TEX264 that can combine with other enzymes to find and destroy toxic proteins that bind to DNA and trigger damage.

Mar 15, 2020

Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping

Posted by in categories: biotech/medical, neuroscience

Prolonged expression of the CRISPR-Cas9 nuclease and gRNA from viral vectors may cause off-target mutagenesis and immunogenicity. Thus, a transient delivery system is needed for therapeutic genome editing applications. Here, we develop an extracellular nanovesicle-based ribonucleoprotein delivery system named NanoMEDIC by utilizing two distinct homing mechanisms. Chemical induced dimerization recruits Cas9 protein into extracellular nanovesicles, and then a viral RNA packaging signal and two self-cleaving riboswitches tether and release sgRNA into nanovesicles. We demonstrate efficient genome editing in various hard-to-transfect cell types, including human induced pluripotent stem (iPS) cells, neurons, and myoblasts. NanoMEDIC also achieves over 90% exon skipping efficiencies in skeletal muscle cells derived from Duchenne muscular dystrophy (DMD) patient iPS cells. Finally, single intramuscular injection of NanoMEDIC induces permanent genomic exon skipping in a luciferase reporter mouse and in mdx mice, indicating its utility for in vivo genome editing therapy of DMD and beyond.

Mar 12, 2020

How chronic stress changes the brain – and what you can do to reverse the damage

Posted by in category: neuroscience

Chemical changes in the brain associated with chronic stress can put our cognition and mood under serious strain.

Mar 12, 2020

New electrodes can better capture brain waves of people with natural hair

Posted by in category: neuroscience

Electrodes weren’t designed for people with thick, curly hair. A redesign is needed, says engineer Pulkit Grover.

Mar 12, 2020

Something strange is going on with the North Star

Posted by in categories: internet, neuroscience, surveillance

Electromagnetic radiation, radar, and surveillance technology are used to transfer sounds and thoughts into people’s brain. UN started their investigation after receiving thousands of testimonies from so-called “targeted individuals” (TIs).”


Magnus Olsson, Geneva 8 March 2020

UN Human Rights Council (HRC) Special Rapporteur on torture revealed during the 43rd HRC that Cyber technology is not only used for internet and 5G. It is also used to target individuals remotely – through intimidation, harassment and public shaming.

Continue reading “Something strange is going on with the North Star” »

Mar 11, 2020

The role of cognitive operations in reality monitoring: a study with healthy older adults and Alzheimer’s-type dementia

Posted by in categories: biotech/medical, life extension, neuroscience

J Gen Psychol. 2009 Jan;136:21–39. doi: 10.3200/GENP.136.1.21–40.

The authors examined the role of cognitive operations in discriminations between externally and internally generated events (e.g., reality monitoring) in healthy and pathological aging. The authors used 2 reality-monitoring distinctions to manipulate the quantity and quality of necessary cognitive operations: discriminating between I performed versus I imagined performing and between I watched another perform versus I imagined another performing. Older adults had more difficulty than did younger adults when discriminating between memories in both versions of the task. In addition, older adults with Alzheimer’s-type dementia showed marked difficulties when attributing a source to imagined actions. The authors interpret these findings in terms of an age difficulty or the failure to use cognitive operations as useful cues during source monitoring.

Mar 11, 2020

Why are humans conscious? An integral relationship in the brain is revealed

Posted by in category: neuroscience

The “neurobiology of consciousness” is one step closer to being understood.

Mar 11, 2020

Braeden Lichti: Investing in Anti-Aging and Rejuvenation Biotechnology

Posted by in categories: biotech/medical, life extension, neuroscience

Useful video for the development of the rejuvenation industry.


Scientists today now have a better understanding of the aging process, giving us a better explanation of the cellular changes that lead our body and brain to decline as we age.