Lifeboat Foundation

Neuroscientists have established in recent decades the idea that some of each day’s experiences are converted by the brain into permanent memories during sleep the same night. Now, a new study proposes a mechanism that determines which memories are tagged as Important enough to linger in the brain until sleep makes them permanent.

Led by researchers from NYU Grossman School of Medicine, the study revolves around brain cells called neurons that “fire” – or bring about swings in the balance of their positive and negative charges — to transmit electrical signals that encode memories. Large groups of neurons in the hippocampus fire together in rhythmic cycles, creating sequences of signals within milliseconds of each other that can encode complex information.

Called “sharp wave-ripples,” these “shouts” to the rest of the brain represent the near-simultaneous firing of 15 percent of hippocampal neurons, and are named for the shape they take when their activity is captured by electrodes and recorded on a graph.

Budapest, Hungary — Twice daily intranasal oxytocin has been associated with improved social functioning, quality of life, and overall symptoms in adults with autism spectrum disorder (ASD), results of a small randomized control trial showed.

“One of the challenges for adults with autism is experiencing poor social interactions and difficulties in making friends. Insufficient social support from peers, friends, and family members can contribute to loneliness in adolescents with ASD, which in turn leads to anxiety, sadness, and social isolation,” said study investigator Saba Faraji Niri, MD, assistant professor of psychiatry, Tehran University of Medical Sciences in Iran.

Recent US data show is relatively common. In addition, previous research suggests intranasal oxytocin significantly increases activity in brain regions that play a role in establishing social interactions.

A new hypothesis paper appearing in the Journal of Parkinson’s Disease on World Parkinson’s Day unites the brain-and body-first models with some of the likely causes of the disease–environmental toxicants that are either inhaled or ingested.

Pointing to a growing body of research linking environmental exposure to Parkinson’s disease, the authors believe the new models may enable the scientific community to connect specific exposures to specific forms of the disease. This effort will be aided by increasing public awareness of the adverse health effects of many chemicals in our environment. The authors conclude that their hypothesis “may explain many of the mysteries of Parkinson’s disease and open the door toward the ultimate goal–prevention.”

In addition to Parkinson’s, these models of environmental exposure may advance understanding of how toxicants contribute to other brain disorders, including autism in children, ALS in adults, and Alzheimer’s in seniors. Dorsey and his colleagues at the University of Rochester have organized a symposium on the Brain and the Environment in Washington, DC, on May 20 that will examine the role toxicants in our food, water, and air are playing in all these brain diseases.

Continue reading “On World Parkinson’s Day, a New Theory Emerges on the Disease’s Origins and Spread” »

Scientists have tested a novel method of providing cells with healthy mitochondria to fight Parkinson’s disease [1].

Parkinson’s disease is the second-most prevalent neurodegenerative disorder, and it affects 10 million people worldwide. The disease is age-related, as its prevalence rises rapidly in people older than 65, although some people are diagnosed much earlier. Parkinson’s disease is characterized by both motor and mental problems: tremor, rigidity (stiffness), and slowness of movement along with memory and thinking deficits.

Parkinson’s disease is caused by the loss of dopamine-producing (dopaminergic) neurons in a brain region called the substantia nigra. Therapeutic options are limited, and some of the existing ones cause nasty side effects.

“The subvolt regime, which is where this material operates, is of enormous interest to researchers looking to make circuits that act similarly to the human brain, which also operates with great energy efficiency.” — Argonne materials scientist Wei Chen “Redox” refers to a chemical reaction that…

As the integrated circuits that power our electronic devices get more powerful, they are also getting smaller. This trend of microelectronics has only accelerated in recent years as scientists try to fit increasingly more semiconducting components on a chip.

Microelectronics face a key challenge because of their small size. To avoid overheating, microelectronics need to consume only a fraction of the electricity of conventional electronics while still operating at peak performance.

Continue reading “Scientists use novel technique to create new energy-efficient microelectronic device” »

The eyes can reveal a lot about the health of our brain. Indeed, problems with the eyes can be one of the earliest signs of cognitive decline. Our latest study shows that a loss of visual sensitivity can predict dementia 12 years before it is diagnosed.

Our research was based on 8,623 healthy people in Norfolk, England, who were followed up for many years. By the end of the study, 537 participants had developed dementia, so we could see what factors might have preceded this diagnosis.

At the start of the study, we asked participants to take a visual sensitivity test. For the test, they had to press a button as soon as they saw a triangle forming in a field of moving dots. People who would develop dementia were much slower to see this triangle on the screen than people who would remain without dementia.

Columbia neuroscientists have identified a genetic mutation that fends off Alzheimer’s in people at high risk and could lead to a new way to protect people from the disease.

Rice University engineers have developed the smallest implantable brain stimulator demonstrated in a human patient. Thanks to pioneering magnetoelectric power transfer technology, the pea-sized device developed in the Rice lab of Jacob Robinson in collaboration with Motif Neurotech and clinicians Dr. Sameer Sheth and Dr. Sunil Sheth can be powered wirelessly via an external transmitter and used to stimulate the brain through the dura ⎯ the protective membrane attached to the bottom of the skull.

The device, known as the Digitally programmable Over-brain Therapeutic (DOT), could revolutionize treatment for drug-resistant depression and other psychiatric or neurological disorders by providing a therapeutic alternative that offers greater patient autonomy and accessibility than current neurostimulation-based therapies and is less invasive than other brain-computer interfaces (BCIs).

Continue reading “Rice team demonstrates miniature brain stimulator in humans” »

Over the course of their lives, humans build subjective internal models outlining the associations between specific environmental stimuli and rewards that could be gained from interacting with them. These experience-based models allow them to infer what benefits they could gain from acting in specific ways.