Lifeboat Foundation

https://youtube.com/watch?v=K-70S1oycR4

1:33…“10 years”.

Dive into the fascinating world of aging research with this thought-provoking video. Join us as we explore the latest breakthroughs and scientific advancements on the quest to reverse aging. Discover the potential strategies, therapies, and technologies that hold promise for extending healthspan and pushing the boundaries of human longevity. Get ready to embark on an exciting journey towards understanding the future of aging reversal.

Continue reading “How Long Until We Reverse the Clock? | Dr David Sinclair” »

At 19:46 Aubrey has a chart for 150 year olds and 1,000 year olds.

6th Edition: AGING & GERONTOLOGY — Sciinov Group.
www.agingcongress.com.

Continue reading “Taking Rejuvenation to Longevity escape velocity: Aubrey De Grey [Aging & Gerontology 2023]” »

I believe that homelessness is often seen in America or other parts of the world as bad but with Finland they have found a housing first approach which has stopped nearly all homelessness there. I believe also regenerative medicine and lots of transhumanistic approaches to medicine would help end their aging and even repair their body if needed. Also if we research the brain we can finally discover and repair genes throughout the body essentially bringing them back near perfect and beyond. Along with ethical approaches towards a more cultural relativistic approach to all humans could show everyone how to coexist. It is still a problem of aging though which is still curable and in extreme cases will be eventually solved in the future. I think with a more comprehensive understanding of all transhumansistic medicine it would be possible to save all lives so no one is left behind.

OK, so the Finns are more generous and just shell out a lot more to help the homeless, right? Actually not. The Finns are simply smarter.

Instead of abandoning the homeless, they housed them. And that led to an insight: people tend to function better when they’re not living on the street or under a bridge. Who would have guessed?

Continue reading “How Finland managed to virtually end homelessness” »

A study led by researchers at Sanford Burnham Prebys has found that in young women, certain genetic mutations are associated with treatment-resistant breast cancer. These mutations are not linked to treatment-resistant breast cancer in older women. The findings, published in the journal Science Advances, could help improve precision medicine and suggest a brand-new way of classifying breast cancer.

“It’s well established that as you get older, you’re more likely to develop cancer. But we’re finding that this may not be true for all cancers depending on a person’s genetic makeup,” says senior author Svasti Haricharan, Ph.D., an assistant professor at Sanford Burnham Prebys. “There may be completely different mechanisms driving cancer in younger and older people, which requires adjusting our view of aging and cancer.”

The research primarily focused on ER+/HER2-breast cancer, which is one of the most common forms of the disease. It is usually treated with hormonal therapies, but for some patients, these treatments don’t work. About 20% of tumors resist treatment from the very beginning, and up to 40% develop resistance over time.

And he mentions Internatioan Aging Systems where you can legally order Rapamycin but I would have to know what experience people have had with them and their product first myself.

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In this video Pelton talks all about rapamycin, its history, how it works, dosage and timing. He also talks about where you can get rapamycin online.

Continue reading “Rapamycin — All You Need To Know & Get Started | Dr Ross Pelton Ep1” »

In a new study published in Aging Cell [1], researchers report that transient activation of the Yamanaka factor Oct4 allowed partial reprogramming of cells, which led to rejuvenation in these cells and in a mouse model of premature aging.

For the first time, researchers have shown that reduced oxygen intake, or “oxygen restriction,” is associated with longer lifespan in lab mice, highlighting its anti-aging potential. Robert Rogers of Massachusetts General Hospital in Boston, US, and colleagues present these findings in a study published May 23rd in the open access journal PLOS Biology.

Research efforts to extend healthy lifespan have identified a number of chemical compounds and other interventions that show promising effects in mammalian lab animals— for instance, the drug metformin or dietary restriction. Oxygen restriction has also been linked to longer lifespan in yeast, nematodes, and fruit flies. However, its effects in mammals have been unknown.

To explore the anti-aging potential of oxygen restriction in mammals, Rogers and colleagues conducted lab experiments with mice bred to age more quickly than other mice while showing classic signs of mammalian aging throughout their bodies. The researchers compared the lifespans of mice living at normal atmospheric oxygen levels (about 21%) to the lifespans of mice that, at 4 weeks of age, had been moved to a living environment with a lower proportion of oxygen (11%—similar to that experienced at an altitude of 5,000 meters).

It sucks that the primary reason this has not gone forward is because it is off patent.

This video is reproduced from a presentation I gave to the Euro-Geroscience Task Force “Challenges in Developing Geroscience Drug Trials” held March 23, 2022 in Toulouse, France. It gives an introduction to the state of research on rapamycin as a potential longevity and healthspan drug and some of the challenges and opportunities for clinical development.

The 2023 edition of the exclusive Longevity Investors Conference is fast approaching, bringing together investors, companies and researchers in Gstaad, Switzerland in September. One of the speakers at this year’s conference is scientist, writer and presenter Dr Andrew Steele, the author of the best-selling book Ageless: The new science of getting older without getting old. When it comes to his views on longevity, Steele sits firmly in the camp that aging, like cancer, is something that humanity should be focused on curing.

Longevity. Technology: Last year, Steele told us he was “absolutely convinced” curing aging is possible, but that significant questions remain around how quickly we can get there. As he prepares to speak to more than 100 investors at LIC, we caught up with Steele to see how his views on longevity have evolved, and what he would say to those considering investing in the field.

First and foremost, Steele, who recently published a new, free chapter of Ageless on the moral, ethical and social consequences of treating aging, believes that longevity represents a huge “human opportunity” for investors.