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Category: life extension – Page 89

Stem Cells & Regenerative Medicine: How Close Are We to Reversing Aging?

Aging is a natural process, but for centuries, humans have been searching for ways to slow it down or even reverse it. Recent advancements in stem cell research and regenerative medicine have given scientists unprecedented insights into aging and potential interventions. With breakthroughs in cellular therapy, gene editing, and tissue engineering, we are closer than ever to finding ways to rejuvenate the human body. But how close are we to reversing aging, and what challenges remain?

Stem cells are the body’s raw materials from which all other specialized cells are generated. They have the unique ability to divide and create identical copies of themselves (self-renewal) or differentiate into specialized cell types. However, as we age, our stem cells decline in both number and efficiency, contributing to tissue degeneration, slower healing, and an increased risk of age-related diseases.

Researchers have been investigating how stem cells can be manipulated to repair damaged tissues, regenerate organs, and potentially reverse signs of aging. By harnessing stem cells, scientists aim to restore youthful function in various tissues and organs, offering promising anti-aging therapies.

New “Humanized” Mice Brings Scientists Closer to Reversing Aging

Washington State University scientists have developed genetically engineered mice that could help accelerate anti-aging research.

Globally, researchers are striving to unlock the secrets of extending human lifespan at the cellular level, where aging occurs gradually due to the shortening of telomeres—the protective caps at the ends of chromosomes that function like shoelace tips, preventing unraveling. As telomeres shorten over time, cells lose their ability to divide for healthy growth, and some eventually begin to die.

However, studying telomeres at the cellular level has been challenging in humans.

The Dvir Lab prints first ever 3D heart using patient’s own cells

Impact of multiplexing noise on multilayer networks of bistable maps.

In a major medical breakthrough, MBM researchers have “printed” the world’s first 3D vascularised engineered heart using a patient’s own cells and biological materials. Until now, scientists in regenerative medicine — a field positioned at the crossroads of biology and technology — have been successful in printing only simple tissues without blood vessels.

“This is the first time anyone anywhere has successfully engineered and printed an entire heart replete with cells, blood vessels, ventricles and chambers,” says Prof. Tal Dvir.

Heart disease is the leading cause of death among both men and women in the United States. Heart transplantation is currently the only treatment available to patients with end-stage heart failure. Given the dire shortage of heart donors, the need to develop new approaches to regenerate the diseased heart is urgent.

Pioneering the Aging Frontier with AI Models

David Furman, an immunologist and data scientist at the Buck Institute for Research on Aging and Stanford University, uses artificial intelligence to parse big data to identify interventions for healthy aging.

Read more.

David Furman uses computational power, collaborations, and cosmic inspiration to tease apart the role of the immune system in aging.

Can AI Defeat Aging and Death? | Ray Kurzweil

We’ve talked a lot about reversing aging and immortality through AI but does it REALLY POSSIBLE? Ray Kurzweil believes we can achieve immortality by 2029, and Bryan Johnson is already using AI to slow his biological age. Is this the future of human longevity?

Chapters:

Intro 0:00 — 1:09
Can We Stop Aging? 1:10 — 2:21
AI Could Reverse Aging Process 2:22 — 2:52
Blueprint Project 2:53 — 5:30
Longevity Escape Velocity 5:31 — 6:57
Scary Consequences 6:58 — 7:43

New Implant Will Help Patients Regenerate Their Own Heart Valves

Every year, more than 5 million people in the USA are diagnosed with heart valve disease, but this condition has no effective long-term treatment. When a person’s heart valve is severely damaged by a birth defect, lifestyle, or aging, blood flow is disrupted. If left untreated, there can be fatal complications.

Valve replacement and repair are the only methods of managing severe valvular heart disease, but both often require repeated surgeries that are expensive, disruptive, and life-threatening. Most replacement valves are made of animal tissue and last up to 10 or 15 years before they must be replaced. For pediatric patients, solutions are extremely limited and can require multiple reinterventions.

Now, Georgia Tech researchers have created a 3D-printed heart valve made of bioresorbable materials and designed to fit an individual patient’s unique anatomy. Once implanted, the valves will be absorbed by the body and replaced by new tissue that will perform the function that the device once served.

Georgia Tech researchers have developed a groundbreaking 3D-printed, bioresorbable heart valve that promotes tissue regeneration, potentially eliminating the need for repeated surgeries and offering a transformative solution for both adult and pediatric heart patients.

Visceral Fat Removal Extends Lifespan: Which Factors May Reduce Visceral Fat?

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