Lifeboat Foundation

Integrated Biosciences, a biotechnology company combining synthetic biology and machine learning to target aging, in collaboration with researchers at the University of California Santa Barbara, today announced a drug discovery platform that enables precise control of the integrated stress response (ISR), a biological pathway that is activated by cells in response to a wide variety of pathological and aging-associated conditions.

A new publication, “Optogenetic control of the integrated stress response reveals proportional encoding and the stress memory landscape,” authored by company founders and featured on the cover of Cell Systems describes a technique that triggers the ISR virtually using light and demonstrates how the accumulation of stress over time shifts a cell’s reaction from adaptation to apoptosis (programmed cell death).

“In a very real way, our platform puts cells into a virtual reality, making them experience stress in the absence of physical stressors,” said Maxwell Wilson, Ph.D., a co-founder of Integrated Biosciences and Assistant Professor of Molecular, Cellular, and Developmental Biology at the University of California Santa Barbara.

Ageing is not an inevitable fact of life – many animals have already found ways to delay death. Their clues might help us all enjoy longer and healthier lives.

Autophagy biology has emerged as a ray of hope in addressing age-related diseases such as neurodegenerative disorders. Substantial effort in academia has been directed at advancing our understanding of the field and paving the way for ground-breaking therapies. But with genuine challenges in harnessing the power of autophagy and in developing effective therapies in this disease area, how close are we to really finding the first autophagy boosting drugs…?

The devastating impact of neurodegenerative diseases such as Parkinson’s, Alzheimer’s and amyotrophic lateral sclerosis (ALS), the most common form of Motor Neurone Disease (MND), cannot be overstated. According to the WHO, neurological diseases affect over a billion people globally and are the leading cause of disability and the second leading cause of death worldwide [1, 2]. Incidence is increasing too, predominantly driven by population growth and aging. And, with no prospect of a cure, people who develop these conditions face a bleak future.

Justifiably, this disease area has been the subject of intensive research for many years and there have been some breakthroughs along the way, possibly offering hope for the development of new therapies. However, translating scientific breakthroughs into viable drugs for patients has been enormously challenging.

In the 1990 fantasy drama — Truly, Madly, Deeply, lead character Nina, (Juliet Stevenson), is grieving the recent death of her boyfriend Jamie (Alan Rickman). Sensing her profound sadness, Jamie returns as a ghost to help her process her loss. If you’ve seen the film, you’ll know that his reappearance forces her to question her memory of him and, in turn, accept that maybe he wasn’t as perfect as she’d remembered. Here in 2023, a new wave of AI-based “grief tech” offers us all the chance to spend time with loved ones after their death — in varying forms. But unlike Jamie (who benevolently misleads Nina), we’re being asked to let artificial intelligence serve up a version of those we survive. What could possibly go wrong?

While generative tools like ChatGPT and Midjourney are dominating the AI conversation, we’re broadly ignoring the larger ethical questions around topics like grief and mourning. The Pope in a puffa is cool, after all, but thinking about your loved ones after death? Not so much. If you believe generative AI avatars for the dead are still a way out, you’d be wrong. At least one company is offering digital immortality already — and it’s as costly as it is eerie.

Continue reading “AI could give us digital immortality but we probably don’t want it” »

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Ben Goertzel, Chief scientist of Hanson Robotics and co-creator of the world’s most famous android citizen, Sophia imagines how the “upload my mind” button will look like in the future.

Continue reading “Can We Live Forever as Digital Copies? | Dr. Ben Goertzel at Brain Bar” »

Some best practices for longevity can be a real bummer. Everyone knows that regular exercise is good for them, but not everyone enjoys it. Eating a few cups of veggies with every meal may not be as fun as a side of fries.

But every so often, the things that are good for us feel good too. Case in point: the humble massage.

A massage for most people is a spa-day splurge, but it’s also an ancient medicinal practice. A thorough rub-down is a great way to celebrate the end of a stressful semester, but there’s more to it than much-deserved relaxation. At its best, a good massage improves bodily motion and function. While science doesn’t say that each massage adds years to your life (not yet, anyway), the benefits of regular massages (for those lucky enough to get them) can add up over time.

In a recent perspective piece published in the Nature Medicine Journal, researchers discussed the current achievements, challenges, and potential opportunities in using digital technologies, such as remote medicine and wearables in geriatric medicine and care.

Study: Digital health for aging populations. Image Credit: GroundPicture/Shutterstock.com.

Discussion: Much of the association between happiness and increased life expectancy could be explained by socio-demographic, lifestyle, health and functioning factors, and especially psychological health and functioning factors.

Keywords: Happiness; Longevity; Mortality; Positive affect; Well-being.

© 2023. The Author(s).

A VERY interesting 6 minutes. People tests? One pill? Next Gen? Hurry, I’m 52! There is an ongoing idea that it will take several kinds of treatments, but many years ago I recall Cynthia Kenyan talking about how some research shows it might come down to a pill.

David Sinclair shares the latest incredible research they are doing.

Continue reading “David Sinclair — ONE PILL” »