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Archive for the ‘life extension’ category: Page 425

Jan 31, 2019

Translating Aging Research – Ending Age Related Diseases 2018

Posted by in categories: biotech/medical, life extension

Ending Age-Related Diseases — October 3, 2018.

This is a video from the Ending Age-Related Diseases 2018 conference, which was held earlier this year at the Cooper Union in New York City. The conference was designed to bring the worlds of research and investment together in one place and explore the progress and challenges that the industry faces in developing and funding therapies to end age-related disease.

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Jan 31, 2019

New Aging Clock Could Predict Your Future Lifespan

Posted by in categories: biotech/medical, genetics, life extension

A new aging clock developed by Professor Steve Horvath and his research team takes measuring your biological age a step further and can accurately predict your future lifespan.

The epigenetic clock

As we age, our DNA experiences chemical changes called DNA methylation (DNAm); these changes are used as a way to measure age and are the basis of the epigenetic clock. As we age, the methylation patterns present on our DNA change, and researchers can measure these changes to work out how old an animal or person is.

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Jan 30, 2019

A Deeper Look At Human Longevity Genes

Posted by in categories: biotech/medical, life extension

(Advances in science and public health are increasing longevity and enhancing the quality of life for people around the world. In this series of interviews with the Milken Institute Center for the Future of Aging, 14 visionaries are revealing exciting trends and insights regarding healthy longevity, sharing their vision for a better future. The Longevity Innovators interviews highlight new discoveries in biomedical and psychosocial science, as well as strategies to promote prevention and wellness for older adults. This is the last story in the series.)

Director of the Longevity Genes Project at the Albert Einstein College of Medicine, Dr. Nir Barzilai has discovered several longevity genes in humans that appear to protect centenarians against major age-related diseases. Barzilai is also co-founder of CohBar, a biotech company developing mitochondria-based therapeutics to treat diseases associated with aging. In an interview with the Milken Institute Center for the Future of Aging, Barzilai explains why some people have longevity genes and the challenges in drug design for age-related diseases:

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Jan 30, 2019

Bedford Day Celebration with Ben Best

Posted by in categories: biotech/medical, cryonics, life extension

Celebrate Bedford Day, a celebration of the first human to be placed into cryonic suspension.

Dr. James Bedford is the oldest person currently in Cryostasis.

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Jan 30, 2019

The Bioart of Neurons and Memory

Posted by in categories: biotech/medical, cryonics, life extension, neuroscience

Demonstrating the preservation of cells after a living organism is pronounced dead and revived is not a traditional bioart topic. But it is an important one. It is a crucial step for advances in the use of lowered temperatures for sustaining the efficacy of organs and organisms during medical procedures, and especially of preserving neurons for the science cryonics.

My recent bioart research is a breakthrough that will help to build momentum toward more advanced studies on information storage within the brain, as well as short-term behaviors of episodic, semantic, procedural, and working memory.

In this article, I will review how I became involved in this research, the guidance along the way, my initial training at 21st Century Medicine, pitching the research project to Alcor, and submitting my proposal to its Research Center (ARC). I will then take you into the lab, the process of trial and error in our first studies, developing a protocol based on olfactory imprinting and applying several cryopreservation methods, developing the migration index, and the rewards of working with a lab technician who became an admiral colleague.

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Jan 30, 2019

Tardigrades, Frozen for 30 Years, Spring Back to Life

Posted by in categories: life extension, space

You can freeze them, burn them, dry them out or even blast them into space, but humble tardigrades can survive it all.

As a demonstration of tardigrade power, a new experiment has shown that even locking the critters in a block of ice for three decades fails to deliver the ultimate knockout.

Japanese researchers successfully brought two tardigrades — often called “water bears” for their claws and head shape — back to life after being frozen for 30 years. A separate team of Japanese researchers with the 24th Japanese Antarctic Research Expedition discovered the eight-legged, microscopic pair of animals back in 1983 in a frozen sample of moss, which was kept below freezing to the present day.

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Jan 30, 2019

Fighting Deadly Drug Resistant Bacteria in Intestines with New Antibiotic

Posted by in categories: biotech/medical, life extension

A new antibiotic developed by a Flinders University researcher is being heralded as a breakthrough in the war against a drug resistant superbug. Bacteria are winning the fight against antibiotics as they evolve to fight off traditional treatments, threatening decades of advancements in modern medicine, with predictions they will kill over 10 million people by 2050. The scientific development of new, effective and safe antibiotics is crucial in addressing the ever-growing threat posed by drug resistant bacteria around the world.

Clostridium difficile infection (CDI) is a potentially deadly infection in the large intestine most common in people who need to take antibiotics for a long period of time, particularly in Australia’s ageing population. Dr Ramiz Boulos, adjunct research associate at Flinders University and CEO of Boulos & Cooper Pharmaceuticsals, says the fact CDI is becoming resistant to traditional antibiotics is alarming and highlights the need to develop more effective treatments.

“Cases of CDI disease are rising and the strains are becoming more lethal. If there is an imbalance in your intestines it can begin to grow and release toxins that attack the lining of the intestines which leads to symptoms,” says Dr Boulos. Over the past ten years, various strains of C. difficile have emerged, and are associated with outbreaks of severe infections worldwide. One particular strain is easily transmitted between people and has been responsible for large outbreaks in hospitals in the United States and Europe. “It’s concerning when you consider CDI is one of the most common infections acquired during hospital visits in the Western hemisphere, and the most likely cause of diarrhea for patients and staff in hospitals.”

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Jan 30, 2019

Instagram Photo

Posted by in category: life extension

I had an amazing time on the podcast with David Sinclair today! He dropped some amazing knowledge about the current state of the science of longevity!

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Jan 30, 2019

Link between aging and microbiome diversity in exceptional mammalian longevity

Posted by in category: life extension

Pharmaceutical microbiology, quality assurance, healthcare, cleanroom, contamination control, microbiology, tim sandle, sterility, disinfection.

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Jan 30, 2019

How Long Will We Live in 2069?

Posted by in categories: biotech/medical, genetics, life extension, neuroscience

A new, very good article on aging, modern aging research and its history, RAAD feest and other initiatives, on model organisms, genetics and future lifespans. “… In early December 2018, just a few months after RAADfest, I visited the Buck Institute for a daylong symposium titled “Live Better Longer: A Celebration of 30 Years of Research on Aging.” That wasn’t an arbitrary demarcation: Aging is one of the rare areas of modern science with a specific launch date. In this case, it was January 1988, when Tom Johnson, a behavioral geneticist at the University of California, Irvine, published a paper that linked a genetic mutation he named “age-1” to longer lifespans in a transparent, microscopic, mostly hermaphroditic roundworm known in scientific circles as C. elegans. Prior to Johnson’s discovery, aging had not received a lot of attention from researchers. In the 1820s, Benjamin Gompertz, a self-trained mathematician, concluded that humans don’t start to break down at some magic age but are constantly declining and losing the ability to repair themselves, a concept now referred to as the Gompertz law of mortality. The first hint that there might be a cellular mechanism underlying the aging process came more than a century later, in the 1930s, when two Cornell scientists discovered that rats kept on calorically restricted diets lived significantly longer than their more satiated brethren. But overall, the field was mostly known as being a haven for charlatans and quacks peddling immortality elixirs and other magical cures — a reputation that continued even after Johnson’s work was published…In 1993, Cynthia Kenyon, an assistant professor at the University of California, San Francisco, discovered that mutations on a different gene, called daf-2, caused C. elegans to live twice as long as expected. Several years later, Gary Ruvkun, a researcher at Harvard Medical School, showed that these so-called worm-aging genes were closely related to genes in the insulin-signaling system of humans. Around the same time, MIT’s Guarente and some of his colleagues discovered the first of several genes in yeast — which are also present in humans — linked to dramatically extended lifespan…” https://medium.com/s/2069/how-long-will-we-live-in-2069-f03e698f6de2


With this promising research on the horizon, how long might humans live in the future? Fantastical claims to longevity have existed since the dawn of recorded time, but reliable data about maximum human lifespan only dates to the mid-1950s, when the Guinness Book of World Records began independently verifying claims. Even then, initially corroborated ages can end up disproven: On December 27, Russian researchers published a paper arguing that the current world record holder, a Frenchwoman named Jeanne Calment, who said she was 122 when she died in 1997, had stolen her mother’s identity and was actually 99 at the time.

Assuming Calment wasn’t a fraud, since 1955, 46 people have made it to age 115. Nine of them have made it to 117 — and only two, Calment and an American woman named Sarah Knauss, have made it past 117. (Knauss died in 1999 at age 119). Over that same time frame, just under 11 billion people have been alive. That means roughly .0000004204133 percent of people have made it to 115. You’re 79,333 times more likely to get hit by lightning than you are to live to 115; 22,455 times more likely to end up in the emergency room from a golf cart accident; and 11,817 times more likely to get murdered.

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