Lifeboat Foundation

Drugs that target multiple aging pathways at once significantly extend the healthspan and lifespan of nematodes.

In a paper published in Developmental Cell, scientists from Yale University have demonstrated how targeting multiple pathways related to aging with different drug combinations can slow aging down and extend healthy lifespan in C. elegans [1].

Abstract

Continue reading “Treating Multiple Aging Pathways Simultaneously Extends Healthy Lifespan Of Nematodes” »

On the 23rd of this month, Dr. David Sinclair did an Ask Me Anything over at the Futurology subreddit in support of the NAD+ Mouse Project on Lifespan.io. There were a range of interesting questions from the community about his work in aging research, particularly the role of NAD+ in aging.

Dr. David A. Sinclair is a Professor in the Department of Genetics at Harvard Medical School and a co-joint Professor in the Department of Physiology and Pharmacology at the University of New South Wales. He is the co-Director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging and a Senior Scholar of the Ellison Medical Foundation. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente; there, he co-discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability.

More recently, he has been in the spotlight for his work with NAD+ precursors and their role in aging and has been helping to develop therapies that replace NAD+, which is lost with aging, in order to delay the diseases of old age. Below are a selection of questions and answers from the AMA, and we urge you to head over to Reddit Futurology to check out the other questions that people asked.

In addition, a small number of posters will be selected for oral presentation.

Poster topics should lie within the scope of the conference: Research contributing to the eventual postponement of age-related decline in health, with an emphasis on measures that repair damage rather than slowing its creation. Poster submissions are due on January 31, 2019.

To submit your poster go to:

Continue reading “The 2019 Undoing Aging Conference will again include poster sessions” »

The brilliant Prof Judith Campisi from Buck Institute on Aging on senescence, senolytics, healthspan and more, a new interview.

Anti-aging pioneer Judith Campisi explains how a recent breakthrough could ward off age-related disease.

A study suggests cardiorespiratory fitness is linked to a longer life, suggesting no exercise is worse for health than smoking or diabetes.

Many mutations accumulate in the esophagus as we age.

Scientists at the MRC Cancer Unit of the Wellcome Sanger Institute and other departments of the University of Cambridge discovered that healthy esophageal tissue accumulates very high numbers of mutations with age, to the point that, by the time middle age is reached, it is likely to contain more cells with a particular mutation than cells without it [1].

Abstract

Continue reading “Mutations Accumulate in Healthy Esophageal Tissue With Age” »

Judith Campisi as a speaker for the 2019 Undoing Aging Conference.

At Lawrence Berkeley National Laboratory and at the Buck Institute for Research on Aging, Dr. Judith Campisi established a broad program to understand the relationship between aging and age-related disease.

Judith Campisi says: “Aging research has entered an era of unprecedented hope for interventions that can prevent, delay and, in some cases, reverse much of the functional decline that is a hallmark of aging. There is still a lot of research to be done! I am delighted to be among the speakers at Undoing Aging 2019, where I will discuss the opportunities and challenges of our recent research.”

Continue reading “We are happy to announce Dr” »

To paraphrase Churchill’s words following the Second Battle of El Alamein: Google’s announcement about their new venture to extend human life, Calico, is not the end, nor even the beginning of the end, but it is, perhaps, the end of the beginning.

(MORE: Google vs. Death)

Since the dawn of civilization, humanity has been enslaved by the knowledge that no lifestyle choice, no medicine, no quirk of fate can enable anyone to live for more than a few decades without suffering progressive, inexorable decline in physical and mental function, leading inevitably to death. So soul-destroying has this knowledge been, for almost everyone, that we have constructed our entire society and world view around ways to put it out of our minds, mostly by convincing ourselves that the tragedy of aging is actually a good thing. And why not? After all, why be preoccupied about something one cannot affect?

Continue reading “Google’s Calico: the War on Aging Has Truly Begun” »

Today we are delighted to announce there is to be a third fund match for the NAD+ Mouse Project!

Today, we are delighted to announce that there is to be a third funding match for the NAD+ Mouse Project!

Dr. David Sinclair will be personally matching the next $5000 in donations for the last 10 days of the campaign to help reach the final $60,000 goal. Now, that is what we call a devoted scientist!

Continue reading “David Sinclair Supports NAD+ Mouse Project with a 5k Fund Match” »