Lifeboat Foundation

We’ve already blown past 100, so what’s next?

Buy Telomerase Inhibitor IX (CAS 368449−04−1), a potent, reversible inhibitor of telomerase activity, from Santa Cruz. Purity: ≥95%, MF: C20H16N2O6.

As we age, the reduced turnover of our cells means we can lose control over how our skin ages. Epidermal stem cells needed to create healthy new skin are significantly reduced and function less efficiently. A discovery based on promising plant stem cell research may allow you to regain control.

Scientists have found that a novel extract derived from the stem cells of a rare apple tree cultivated for its extraordinary longevity shows tremendous ability to rejuvenate aging skin. By stimulating aging skin stem cells, this plant extract has been shown to lessen the appearance of unsightly wrinkles. Clinical trials show that this unique formulation increases the longevity of skin cells, resulting in skin that has a more youthful and radiant appearance.

A new publication highlights how the complex interaction of NAD+ and cellular senescence pathways may complicate proposed anti-aging therapies that boost NAD+ using precursors.

What are epigenetic alterations?

One of the proposed reasons we age is the changes to gene expression that our cells experience as we get older; these are commonly called epigenetic alterations. These alterations harm the fundamental functions of our cells and can increase the risk of cancer and other age-related diseases.

Continue reading “NAD+ and Cellular Senescence Pathways Interact” »

A mathematical equation has proven that controlling one of the two major changes in a cell—decay or cancerous growth—enhances the other, causing inevitable death.

De Grey on aging… Respect AEWR.

Aubrey de grey, chief science officer, SENS research foundation.

The gut microbiome appears to be increasingly responsible for at least some of the decline of the immune system during aging, and a new mouse study shows that it is reversible.

The gut microbiome

The microbiome describes a varied community of bacteria, archaea, eukarya, and viruses that inhabit our guts. The four bacterial phyla of Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria comprise 98% of the intestinal microbiome.

Continue reading “Transplanting Gut Microbes from Young to Old Mice Reverses Immune Decline” »

University of Maryland researchers analyzed an evolutionary tree reconstructed from the DNA of a majority of known bat species and found four bat lineages that exhibit extreme longevity. They also identified, for the first time, two life history features that predict extended life spans in bats.

Their work is described in a research paper, published in the April 10, 2019 issue of the journal Biology Letters, which concluded that horseshoe bats, long-eared bats, the common vampire bat and at least one lineage of mouse-eared bats all live at least four times longer than other, similarly sized mammals. The researchers also found that a high-latitude home range and larger males than females can be used to predict a given bat species’ life span.

“Scientists are very interested in finding closely related species in which one is long lived and one is short lived, because it implies that there has been some recent change to allow one species to live longer,” said Gerald Wilkinson, a biology professor at UMD and lead author of the paper. “This study provides multiple cases of closely related species with varying longevity, which gives us many opportunities to make comparisons and look for some underlying mechanism that would allow some species to live so long.”

Dr. Alan Green’s patients travel from around the country to his tiny practice in Queens, N.Y., lured by the prospect of longer lives.

Over the past two years, more than 200 patients have flocked to see Green after learning that two drugs he prescribes could possibly stave off aging. One 95-year-old was so intent on keeping her appointment that she asked her son to drive her from Maryland after a snowstorm had closed the schools.

Green is among a small but growing number of doctors who prescribe drugs “off-label” for their possible anti-aging effects. Metformin is typically prescribed for diabetes, and rapamycin prevents organ rejection after a transplant, but doctors can prescribe drugs off-label for other purposes — in this case, for “aging.”

Continue reading “The surprising way some people are fighting aging” »