Lifeboat Foundation

New video from our 2019 Undoing Aging conference: Mikhail Shchepinov, Chief Science Officer at Retrotope, Inc., on aging and diseases resulting from the gradual accumulation of oxidative damages.

undoing-aging.org/videos/mikhail-shchepinov-presenting-at-undoing-aging-2019

____________

The journal club hosted by Dr. Oliver Medvedik returns for July and takes a look at the new SIRT6 evolutionary biology paper by Dr. Vera Gorbunova and collaborators, showing a relationship between enhanced SIRT6 function and longevity.

Abstract DNA repair has been hypothesized to be a longevity determinant, but the evidence for it is based largely on accelerated aging phenotypes of DNA repair mutants. Here, using a panel of 18 rodent species with diverse lifespans, we show that more robust DNA double-strand break (DSB) repair, but not nucleotide excision repair (NER), coevolves with longevity. Evolution of NER, unlike DSB, is shaped primarily by sunlight exposure. We further show that the capacity of the SIRT6 protein to promote DSB repair accounts for a major part of the variation in DSB repair efficacy between short- and long-lived species. We dissected the molecular differences between a weak (mouse) and a strong (beaver) SIRT6 protein and identified five amino acid residues that are fully responsible for their differential activities. Our findings demonstrate that DSB repair and SIRT6 have been optimized during the evolution of longevity, which provides new targets for anti-aging interventions.

Literature

Continue reading “The journal club hosted by Dr. Oliver Medvedik returns for July and takes a look at the new SIRT6 evolutionary biology paper by Dr. Vera Gorbunova and collaborators” »

Ending Age-Related Diseases 2019 is over, and the dust is starting to settle after what can only be described as a hugely successful event for our organization. This was our second year of running a conference, and once more, we focused on the research and investment areas of rejuvenation biotechnology.

Totally sold out

This year, our venue at the Frederick P. Rose Auditorium at the Cooper Union in New York City was so popular that we totally sold out of tickets this year and had to turn people away! Our advice for next year is definitely to book early to avoid disappointment and take advantage of the lower prices that early booking offers.

Cell freezing (cryopreservation)—which is essential in cell transfusions as well as basic biomedical research—can be dramatically improved using a new polymeric cryoprotectant, discovered at the University of Warwick, which reduces the amount of ‘anti-freeze’ needed to protect cells.

The ability to freeze and store cells for cell-based therapies and research has taken a step forward in the paper “A synthetically scalable poly(ampholyte) which dramatically Enhances Cellular Cryopreservation.” published by the University of Warwick’s Department of Chemistry and Medical School in the journal Biomacromolecules. The new polymer material protects the cells during freezing, leading to more cells being recovered and less solvent-based antifreeze being required.

Cryopreservation of cells is an essential process, enabling banking and distribution of cells, which would otherwise degrade. The current methods rely on adding traditional ‘antifreezes’ to the cells to protect them from the cold stress, but not all the cells are recovered and it is desirable to lower the amount of solvent added.

Longevity investor and visionary Sergey Young, founder of Longevity Vision Fund and Innovation Board Member of XPRIZE Foundation, delivers “7 Signs of Longevity Revolution” keynote at Barclay’s recent “Accelerating Evolution” conference, discussing recent developments in the longevity industry.

Watch to find out the forecasts for the industry’s trajectory of growth in the coming years, the increasing emergence of practical, real-world applications in the longevity sphere and how Longevity Vision Fund striving to be on the very forefront of the ongoing Longevity Revolution that is already happening around us today.

#longevity #lvf #longevityvisionfund #lifeextension #longevityrevolution #sergeyyoung #barclays

In about 100 years, theoretical physicist Michio Kaku believes we’ll explore the universe as pure consciousness — traveling at the speed of light, looking at asteroids, comets, meteors, and eventually the stars. “All of this within the laws of physics,” he says.

My new article from Quartz about an annual #Longevity Peace Prize, and why it could help spread anti-aging aims far and wide across the planet:

Lead transhumanist Zoltan Istvan believes creating a major prize can help solve the problem of accessibility to developing longevity sciences.

https://www.linkedin.com/pulse/longevity-new-government-stra…-colangelo