Lifeboat Foundation

Here, we will first summarize the experimental achievements over the last 7 years in cell and animal rejuvenation. Then, a comparison will be made between the principles of the cumulative DNA damage theory of aging and the basic facts underlying the epigenetic model of aging, including Horvath’s epigenetic clock. The third part will apply both models to two natural processes, namely, the setting of the aging clock in the mammalian zygote and the changes in the aging clock along successive generations in mammals. The first study demonstrating that skin fibroblasts from healthy centenarians can be rejuvenated by cell reprogramming was published in 2011 and will be discussed in some detail. Other cell rejuvenation studies in old humans and rodents published afterwards will be very briefly mentioned. The only in vivo study reporting that a number of organs of old progeric mice can be rejuvenated by cyclic partial reprogramming will also be described in some detail. The cumulative DNA damage theory of aging postulates that as an animal ages, toxic reactive oxygen species generated as byproducts of the mitochondria during respiration induce a random and progressive damage in genes thus leading cells to a progressive functional decline. The epigenetic model of aging postulates that there are epigenetic marks of aging that increase with age, leading to a progressive derepression of DNA which in turn causes deregulated expression of genes that disrupt cell function. The cumulative DNA damage model of aging fails to explain the resetting of the aging clock at the time of conception as well as the continued vitality of species as millenia go by. In contrast, the epigenetic model of aging straightforwardly explains both biologic phenomena. A plausible initial application of rejuvenation in vivo would be preventing adult individuals from aging thus eliminating a major risk factor for end of life pathologies. Further, it may allow the gradual achievement of whole body rejuvenation.

Calico will be conducting research until 2022, when it will enter “Phase 2a studies” — or as experts have hinted, human testing — and finally the “late-stage development activities.”

By The Telegraph 3 days…

The next step for our Forever Healthy Berlin meetup…

We are a community collaborating on how to implement our early stage rejuvenation treatments.

The world has started the transition from an era where we were utterly helpless about our aging process to one where aging is under full medical control, and age-related diseases are a thing of the dark past.

Continue reading “Forever Healthy (Berlin, Germany)” »

Thanks to Authority Magazine and Fotis Georgiadis for the interview — Bioquark inc. (http://www.bioquark.com) — Regeneration, Disease Reversion, Age Rejuvenation — https://medium.com/authority-magazine/the-future-is-now-we-a…cc6dc8ebf1

BEIJING, Dec. 28 (Xinhua) — A Chinese research group has identified a gene variant that plays a key role in the development of Alzheimer’s disease in Han Chinese, the largest ethnic group in China.

The study was recently published by the National Science Review, an English journal affiliated with the Chinese Academy of Sciences (CAS).

Alzheimer’s disease (AD) is an irreversible, progressive brain disorder that slowly destroys memory, thinking skills and the ability to carry out simple tasks. The disease affects about 48 million people worldwide, and the number is expected to increase with the aging population. There is no effective cure.

There has been considerable interest in fisetin recently, especially for its potential as a senolytic, which clears away dysfunctional senescent cells that accumulate with aging. Researchers believe that fisetin may be useful in increasing the healthy period of life known as healthspan.

What is Fisetin?

Fisetin is a naturally occurring flavonol and part of the flavonoid family of polyphenols. Fisetin also acts as a pigment and influences the color of various fruits and vegetables. It can be found in many common fruits and vegetables, although the amounts greatly vary.

Continue reading “Fisetin May be a Low-Hanging Fruit for Aging” »

Merry Christmas

Is the Fountain of Youth still just a dream, or does hope spring eternal when it comes to beating the curse of aging? Having haunted us for centuries, is a solution finally within our grasp? We spoke to Dr Aubrey de Grey, anti-aging pioneer, chief science officer, and co-founder of SENS Research Foundation.

Follow @SophieCo_RT

Continue reading “There will be no old people – anti-aging SophieCo” »

I was in a really interesting 1-hour debate yesterday with Jean-Francois Gariépy who runs a well-known YouTube channel The Public Space, sometimes associated with the Alt-Right. We discussed #transhumanism. I think the debate caught a lot of people by surprise. While I believe in and embrace total diversity, I despise the oppression of human biology and death, and advocate for any means possible to overcome it—including genetic modification and merging with machines. The debate makes me look like the aggressor. But it only proves what I’ve always said, that issues of race and traditional cultural bigotry are minor compared to the issues of humanity battling aging and death itself. All of us are currently in a war to not die:

An important debate on whether or not humanity should play with their own genes. Guest: Zoltan Istvan, transhumanist.

Continue reading “Should We Replace Ourselves? | Zoltan Istvan vs. JFG, TPS #257” »

Ok, the new version of my global risk prevention map is up (pdf link is in comments) and now it is accompanied by recently the published article “Approaches to the Prevention of Global Catastrophic Risks.”

Abstract: Many global catastrophic and existential risks (X-risks) threaten the existence of humankind. There are also many ideas for their prevention, but the meta-problem is that these ideas are not structured. This lack of structure means it is not easy to choose the right plan(s) or to implement them in the correct order. I suggest using a “Plan A, Plan B” model, which has shown its effectiveness in planning actions in unpredictable environments. In this approach, Plan B is a backup option, implemented if Plan A fails. In the case of global risks, Plan A is intended to prevent a catastrophe and Plan B to survive it, if it is not avoided. Each plan has similar stages: analysis, planning, funding, low-level realization and high-level realization. Two variables—plans and stages—provide an effective basis for classification of all possible X-risks prevention methods in the form of a two-dimensional map, allowing the choice of optimal paths for human survival. I have created a framework for estimating the utility of various prevention methods based on their probability of success, the chances that they will be realized in time, their opportunity cost, and their risk. I also distinguish between top-down and bottom-up approaches.