Lifeboat Foundation

Scientists from the RIKEN Center for Integrative Medical Science (IMS) and Keio University School of Medicine in Japan have used single-cell RNA analysis to find that supercentenarians—meaning people over the age of 110—have an excess of a type of immune cell called cytotoxic CD4 T-cells.

Supercentenarians are a unique group of people. First, they are extremely rare. For example, in Japan in 2015 there were more than 61,000 people over the age of 100, but just 146 over the age of 110. And studies have found that these individuals were relatively immune to illnesses such as infections and cancer during their whole lifetimes. This led to the idea that it might be that they have a particularly strong immune system, and the researchers set out to find out what might explain this.

To answer the question, they looked at circulating immune cells from a group of supercentenarians and younger controls. They acquired a total of 41,208 cells from seven supercentenarians (an average of 5,887 per subject) and 19,994 cells for controls (an average of 3,999 per subject) from five controls aged in their fifties to eighties. They found that while the number of B-cells was lower in the supercentenarians, the number of T-cells was approximately the same, and in particular, the number of one subset of T-cells was increased in the supercentenarians. Analyzing these cells, the authors found that the supercentenarians had a very high level of cells that are cytotoxic, meaning that they can kill other cells, sometimes amounting to 80 percent of all T-cells, compared to just 10 or 20 percent in the controls.

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We’ve been raised with the belief that death is inevitable, and so during our lives we consider the legacy of what each of us leaves behind. But what if you had unlimited time to pursue your life’s work, your hobbies, and your dreams.

Continue reading “Can We Really Live Forever? | Unveiled” »

What if you could cheat death and live forever? To people in the radical life extension movement, immortality is a real possibility. Leah Green spends a long weekend at RAADfest, a meeting of scientists, activists and ordinary people who want to extend the human lifespan. So is reversing your age a real possibility? And what’s behind this wish to live forever?
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Continue reading “Can we live forever? | Death Land” »

The combination treatment reversed diabetes and obesity while improving heart and kidney function—even when those organs had already begun failing.

On this episode of Anti-Aging Hacks show, we get into the following topics:

1. What is Gene Therapy and how Practical is it?

Continue reading “How Gene Therapy can Help You Stop Aging, Build Muscles, and Fight Diseases” »

Death means an end, but one recent research challenges the idea and fuels the possibility of reviving the brain. And it has plunged the scientific community into an ethical debate.

Physical movements, thoughts, and actions are traits that define how we know the difference between what’s alive and what’s lifeless i.e. death. But beyond that, we hardly understand what death means. We’ve known that death is an eventuality and irreversible. But recent research done back in April 2019 changed all that. Consequently, science is making us rethink the definition of death and the sheer fact that it is permanent.

Continue reading “Immortality Debate: Can Science Cheat Death?” »

What if you could cheat death and live for ever? To people in the radical life extension movement, immortality is a real possibility. Leah Green spends a long weekend at RAADfest, a meeting of scientists, activists and ordinary people who want to extend the human lifespan. So is reversing your age a real possibility? And what’s behind the wish for immortality?

Albert Einstein’s famous expression “spooky action at a distance” refers to quantum entanglement, a phenomenon seen on the most micro of scales. But machine learning seems to grow more mysterious and powerful every day, and scientists don’t always understand how it works. The spookiest action yet is a new study of heart patients where a machine-learning algorithm decided who was most likely to die within a year based on echocardiogram (ECG) results, reported by New Scientist. The algorithm performed better than the traditional measures used by cardiologists. The study was done by researchers in Pennsylvania’s Geisinger regional healthcare group, a low-cost and not-for-profit provider.

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The tiny hydra, a freshwater invertebrate related to jellyfish and corals, has an amazing ability to renew its cells and regenerate damaged tissue. Cut a hydra in half, and it will regenerate its body and nervous system in a couple of days. Researchers at the University of California, Davis have now traced the fate of hydra’s cells, revealing how three lines of stem cells become nerves, muscles or other tissues.

Celina Juliano, assistant professor in the UC Davis Department of Molecular and Cellular Biology, project scientist Stefan Siebert and colleagues including Jeff Farrell, a postdoctoral researcher at Harvard University, sequenced the RNA transcripts of 25,000 single hydra cells to follow the genetic trajectory of nearly all differentiated cell types.

“The beauty of single-cell sequencing and why this is such a big deal for developmental biologists is that we can actually capture the genes that are expressed as cells differentiate from stem cells into their different cell types,” Juliano said.