There’s only one alliterative phrase i like more than ‘the sheekey science show’, and that’s ‘anti-aging antibodies’. now, as it happens, one thing i spent a lot of time working on this year is antibodies. Antibody, make me feel this way. now while i cannot tell you yet what i was/am doing, i can tell you about two recent science stories that exploit antibodies to extend mouse lifespan. Firstly, i will bring your attention to this paper — immunotherapy targeting isoDGR-protein damage extends lifespan and then we’ll look at this paper that came out last month — Inhibition of IL-11 signalling extends mammalian healthspan.
Use code coolworlds at https://incogni.com/coolworlds to get an exclusive 60% off an annual Incogni plan. The idea of Dyson Spheres was a radical proposal by the physicist Freeman Dyson, an enormous shell of material enveloping a star. Dyson’s idea may be over half a century old, but interest in looking for such objects has only grown in the decades since. But how would such structures work? Are they physically even possible? And what might someone use them for? Today, we dive into the physics of Dyson spheres. Written & presented by Prof. David Kipping. Edited by Jorge Casas. Special thanks to Jason Wright for fact checking. → Support our research: https://www.coolworldslab.com/support → Get merch: https://teespring.com/stores/cool-wor… Check out our podcast: / @coolworldspodcast THANK-YOU to T. Widdowson, D. Smith, L. Sanborn, C. Bottaccini, D. Daughaday, S. Brownlee, E. West, T. Zajonc, A. De Vaal, M. Elliott, B. Daniluk, S. Vystoropskyi, S. Lee, Z. Danielson, C. Fitzgerald, C. Souter, M. Gillette, T. Jeffcoat, J. Rockett, D. Murphree, M. Sanford, T. Donkin, A. Schoen, K. Dabrowski, R. Ramezankhani, J. Armstrong, S. Marks, B. Smith, J. Kruger, S. Applegate, E. Zahnle, N. Gebben, J. Bergman, C. Macdonald, M. Hedlund, P. Kaup, W. Evans, N. Corwin, K. Howard, L. Deacon, G. Metts, R. Provost, G. Fullwood, N. De Haan, R. Williams, E. Garland, R. Lovely, A. Cornejo, D. Compos, F. Demopoulos, G. Bylinsky, J. Werner, S. Thayer, T. Edris, F. Blood, M. O’Brien, D. Lee, J. Sargent, M. Czirr, F. Krotzer, I. Williams, J. Sattler, B. Reese, O. Shabtay, X. Yao, S. Saverys, A. Nimmerjahn, C. Seay, D. Johnson, L. Cunningham, M. Morrow, M. Campbell, B. Devermont, Y. Muheim, A. Stark, C. Caminero, P. Borisoff, A. Donovan & H. Schiff. REFERENCES ► Wright, J. 2020, “Dyson Spheres”, Serbian Astronomical Journal, 200, 1: https://arxiv.org/abs/2006.16734 ► Dyson, F. 1960, “Search for Artificial Stellar Sources of Infrared Radiation”, Science, 131, 1667: https://ui.adsabs.harvard.edu/abs/196… ► Dyson, F. 1960, Science, 132,250 ► NASA IRB JWST Report 2018: https://www.nasa.gov/wp-content/uploa… ► Papagiannis, M. D. 1985, “SETI — a look into the future.”, The search for extraterrestrial life: recent development, 543: https://ui.adsabs.harvard.edu/abs/198… ► Scoggins, M. & Kipping, D. 2023, “Lazarus stars: numerical investigations of stellar evolution with star-lifting as a life extension strategy”, MNRAS, 523, 3251: https://arxiv.org/abs/2210.02338 MUSIC Licensed by SoundStripe.com (SS) [shorturl.at/ptBHI], Artlist.io, via CC Attribution License (https://creativecommons.org/licenses/…) or with permission from the artist. 0:34 Tamuz Dekel — Quiet Pull 3:05 We Dream of Eden — Discovery 4:23 Hill — World of Wonder [https://open.spotify.com/track/7kYX7G… ] 6:28 Chris Zabriskie — Music from Neptune Flux 4 8:59 Hill — Arctic Warmth 11:54 Hill — Northern Borders 15:13 Hill — Fragile 17:45 Indive — Trace Correction CHAPTERS 0:00 Prologue 0:39 Inception 3:11 Incogni 4:27 Mechanical Stability 8:31 Gravitational Stability 11:08 Stellar Feedback 13:42 Computational Limits 16:23 Rings and Swarms 17:45 Outro and Credits #DysonSphere #Astronomy #CoolWorlds
RAADfest is the largest and most immersive event in the world focused on super-longevity for a general audience. Bringing together cutting-edge science, inspiration, entertainment and fun, RAADfest is more than just a conference – it’s a celebration of life. From brain longevity and sexual health, to senolytics, personalized medicine and helping your pets live longer too, RAADfest provides the information and inspiration to enable people to take charge of their longevity.
I have a new essay out via the wonderful site Merion West. The article is based on some of my experimental writings at Oxford. I hope you’ll read and consider it. I’m highly worried life extension science isn’t moving forward fast enough!
“Sadly, biological humans are likely to be mortal for centuries more, unless a dramatic increase of both resources and life extension scientists are marshaled.”
Certain well-known gerontologists and longevity experts around the world believe that sometime in this century—probably in the next 15–50 years—medicine will likely overcome and cure most forms of disease, and even death itself. Billionaires such as Meta’s Mark Zuckerberg, Amazon’s Jeff Bezos, Alphabet’s Larry Page, and Oracle’s Larry Ellison have jumped on board, pledging billions of dollars to “conquering all disease by this century” and mortality altogether.
A team of researchers reveals the cellular pathology of “dry” age-related macular degeneration (AMD); discovering the potential source of dysfunction in the process whereby cells in the retina remove waste.
