Lifeboat Foundation

The challenges and opportunities of longevity research on the journey to redefine the process and meaning of aging; can the world handle the real impact of prolonging life?

We’re joined by Dr. Denis Noble, Professor Emeritus of Cardiovascular Physiology at the University of Oxford, and the father of ‘systems biology’. He is known for his groundbreaking creation of the first mathematical model of the heart’s electrical activity in the 1960s which radically transformed our understanding of the heart.

Dr. Noble’s contributions have revolutionized our understanding of cardiac function and the broader field of biology. His work continues to challenge long-standing biological concepts, including gene-centric views like Neo-Darwinism.

Continue reading “Denis Noble — Why The Last 80 Years of Biology was Wrong” »

Researchers from the Color and Food Quality group at the Faculty of Pharmacy, University of Seville, in partnership with Dr. Marina Ezcurra’s team at the University of Kent (UK), have demonstrated that the carotenoid phytoene extends the lifespan of the nematode Caenorhabditis elegans. Additionally, it delays the onset of paralysis linked to amyloid plaque formation in an Alzheimer’s disease model.

Specifically, increases in longevity of between 10 and 18.6% and decreases in the proteotoxic effect of plaques of between 30 and 40% were observed. The studies, which form part of Ángeles Morón Ortiz’s doctoral thesis, tested pure phytoene and extracts rich in this carotenoid obtained from microalgae.

According to Dr. Paula Mapelli Brahm, “These are very exciting preliminary results, so we are looking for funding to continue this line of research and to find out by what mechanisms these effects are produced.”

The LEV Foundation is a nonprofit organization dedicated to advancing the field of rejuvenation biotechnology with the goal of reversing biological aging. Under the leadership of renowned gerontologist Aubrey de Grey, the foundation focuses on conducting early-stage research on animals, specifically testing combination therapies that aim to dramatically extend lifespan. LEV Foundation stands out in the aging research community by targeting middle-aged mice, developing treatments that could one day be applied to humans, helping achieve longevity escape velocity — the point at which aging can be controlled through medical interventions.

U.S. researchers developed CheekAge, a tool that reliably estimates mortality risk.

Researchers in the United States have created a next-generation tool named CheekAge, which uses methylation patterns found in easily obtainable cheek cells.

In a groundbreaking discovery, the team has demonstrated that CheekAge can reliably estimate mortality risk, even when epigenetic data from different tissues are utilized for analysis.

Continue reading “US scientist reveal mouth swab that can gauge your risk of death” »

Join our in-depth exploration of telomeres and their incredible potential in reversing aging! Discover the science behind telomere enhancement and how it can slow down the aging process. Featuring expert insights from Dr. Michael Roizen, this video unveils cutting-edge research that could change the way we view longevity. #AgingReversal #Telomeres #LongevityScience #DrMichaelRoizen #HealthInnovation #StemCellResearch #AntiAging #YouthfulLiving #Biotechnology #TelomerePharmaceuticals

Sleep, fasting, exercise, green porridge, black coffee, a healthy social life—there is an abundance of advice out there on how to live a good, long life. Researchers are working hard to determine why some people live longer than others, and how we get the most out of our increasingly long lives.

Now researchers from the Center for Healthy Aging, Department of Cellular and Molecular Medicine at the University of Copenhagen have discovered that a particular protein known as OSER1 has a great influence on longevity. The research is published in the journal Nature Communications.

“We identified this protein that can extend longevity. It is a novel pro-longevity factor, and it is a protein that exists in various animals, such as fruit flies, nematodes, silkworms, and in humans,” says Professor Lene Juel Rasmussen, senior author behind the new study.

Macroautophagy (hereafter autophagy) is a cellular recycling process that degrades cytoplasmic components, such as protein aggregates and mitochondria, and is associated with longevity and health in multiple organisms. While mounting evidence supports that autophagy declines with age, the underlying molecular mechanisms remain unclear. Since autophagy is a complex, multistep process, orchestrated by more than 40 autophagy-related proteins with tissue-specific expression patterns and context-dependent regulation, it is challenging to determine how autophagy fails with age. In this review, we describe the individual steps of the autophagy process and summarize the age-dependent molecular changes reported to occur in specific steps of the pathway that could impact autophagy.