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Researchers have identified an important gene that could enable more targeted treatment for cancer.

Scientists from Agency for Science, Technology and Research (A*STAR)’s Institute of Molecular and Cell Biology (IMCB) and Genome Institute of Singapore (GIS), as well as the NUS Cancer Science Institute of Singapore (CSI Singapore), National Cancer Centre Singapore (NCCS) and Nanyang Technological University (NTU), have identified an important cancer progression mechanism that is observed in 90 percent of cancer cells. This discovery, which was published in Nucleic Acid Research, will guide further development of cancer specific drugs with potentially fewer side effects.

Long-baseline neutrino experiments are paving the way for the solution of two outstanding puzzles in neutrino physics—mass ordering and charge-parity violation.

Nanoparticle “backpack” repairs damaged stem cells. Stem cells that might save a baby’s life and be utilized to treat illnesses like lymphoma and leukemia are found in the umbilical cord of newborns. Because of this, many new parents decide to preserve (“bank”) the umbilical cord blood’s abundant s.

Stem cells that might save a baby’s life and be utilized to treat illnesses like lymphoma and leukemia are found in the umbilical cord of newborns. Because of this, many new parents decide to preserve (“bank”) the umbilical cord blood’s abundant stem cells for their child. However, since gestational diabetes destroys stem cells and makes them useless, parents are not given this choice in the 6 to 15% of pregnancies who are impacted by the illness.

In a study that will be published in the journal Communications Biology, bioengineers at the University of Notre Dame have now shown that a new approach may heal the injured stem cells and allow them to once again grow new tissues.

Specially-created nanoparticles are the key component of this new strategy. Each spherical nanoparticle may store medication and deliver it specifically to the stem cells by attaching it to the surface of the cells. These nanoparticles are about 150 nanometers in diameter or about a fourth of the size of a red blood cell. The particles deliver the medication gradually as a result of their unique tuning, which makes them very effective even at very low dosages.

Summary: Researchers have identified a new type of retinal ganglion cells.

Source: Northwestern University.

Northwestern Medicine investigators have identified a new type of retinal ganglion cell, the neurons in the retina that encode the visual environment and transmit information back to the brain, according to a study published in Neuron.

DNA-based information is a new interdisciplinary field linking information technology and biotechnology. The field hopes to meet the enormous need for long-term data storage by using DNA as an information storage medium. Despite DNA’s promise of strong stability, high storage density and low maintenance cost, however, researchers face problems accurately rewriting digital information encoded in DNA sequences.

Generally, DNA data storage technology has two modes, i.e., the “in vitro hard disk mode” and the “in vivo CD mode.” The primary advantage of the in vivo mode is its low-cost, reliable replication of chromosomal DNA by cell replication. Due to this characteristic, it can be used for rapid and low-cost data copy dissemination. Since encoded DNA sequences for some information contain a large number of repeats and the appearance of homopolymers, however, such information can only be “written” and “read,” but cannot be accurately “rewritten.”

To solve the rewriting problem, Prof. Liu Kai from the Department of Chemistry, Tsinghua University, Prof. LI Jingjing from the Changchun Institute of Applied Chemistry (CIAC) of the Chinese Academy of Sciences, and Prof. Chen Dong from Zhejiang University led a research team that recently developed a dual-plasmid editing system for accurately processing digital information in a microbial vector. Their findings were published in Science Advances.

A research team led by the Technical University of Munich (TUM) has succeeded for the first time in producing a molecular electric motor using the DNA origami method. The tiny machine made of genetic material self-assembles and converts electrical energy into kinetic energy. The new nanomotors can be switched on and off, and the researchers can control the rotation speed and rotational direction.

Be it in our cars, drills or automatic coffee grinders—motors help us perform work in our everyday lives to accomplish a wide variety of tasks. On a much smaller scale, natural molecular motors perform vital tasks in our bodies. For instance, a motor protein known as ATP synthase produces the molecule adenosine triphosphate (ATP), which our body uses for short-term storage and transfer of energy.

While natural molecular motors are essential, it has been quite difficult to recreate motors on this scale with mechanical properties roughly similar to those of natural molecular motors like ATP synthase. A research team has now constructed a working nanoscale molecular rotary motor using the DNA origami method and published their results in Nature. The team was led by Hendrik Dietz, Professor of Biomolecular Nanotechnology at TUM, Friedrich Simmel, Professor of Physics of Synthetic Biological Systems at TUM, and Ramin Golestanian, director at the Max Planck Institute for Dynamics and Self-Organization.

The researchers wanted to create robots that could pick up and sort molecules within a designated space. This makes it possible for DNA molecules to serve as the building blocks for 3D nanostructures that self-assemble in a predetermined shape. Tiny DNA-based robots and other nanodevices will deliver medicine inside our bodies, detect the presence of deadly pathogens, and help manufacture increasingly smaller electronics.

This enabled the researchers to design a nano-robot composed of three DNA origami structures. To help it maneuver within the designated space, the robot had a “leg” with a pair of feet. An “arm” with a “hand” allowed it to carry cargo, and a third component was added to tell the hand when a specific drop-off point had been reached so it would know to release the cargo. It allows researchers to carry out the entire design truly in 3D. Earlier design tools only allowed creation in 2D, forcing researchers to map their creations into 3D.

The software helps researchers design ways to take tiny strands of DNA and combine them into complex structures with parts like rotors and hinges that can move and complete a variety of tasks, including drug delivery. The robot will also enable researchers to more precisely determine important signaling pathways for a variety of biological and pathological processes that are stimulated at the cellular level during the application of force.

Holographic teleportation could solve the many issues that 2D virtual meetings have these days. Besides, you could simply beam into work while at home.

Researchers at the University of Western Ontario recently completed the world’s first-ever international holographic teleportation.

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In a recent study published in the journal Nature titled “A time-resolved, multi-symbol molecular recorder via sequential genome editing,” a group of researchers from the University of…