Lifeboat Foundation

Interesting.

A team of Melbourne researchers believe they have discovered a new immune cell which is able to fight the infectious and potentially lethal bacteria, Legionella.

A team of specialist immunologists and microbiologists from the University of Melbourne and the Peter Doherty Institute for Infection and Immunity conducted a study which was able to determine a new cell type responsible for combating the attack of the bacteria.

The team was able to break down the impact of the legion of immune cells in the lung, which communicate to destroy the legionella bacteria.

Continue reading “Aust’n researchers discover immune cells to fight Legionella bacteria” »

When cancer hits, your immune system shuts down. Over the past 5–10 years, research into cancer has therefore increasingly focused on helping the immune system start up again. Because if we succeed in that, there is much to indicate that this approach will prove significantly more effective than the aggressive, all encompassing chemotherapy treatments we currently use.

One of the initiatives in this area is the work of Professor Thomas Andresen from DTU Nanotech. He has recently been awarded a grant from Innovation Fund Denmark for a project in which biological nano-drones are used to train the immune system to recognize cancer cells; and kill them.

This is something it cannot do on its own, because cancer cells are adept at concealing themselves. It is true that when chemotherapy or radiotherapy is used to kill cancer cells today, the immune system steps in afterwards to clear away the dead cells, but it doesn’t learn anything from the process. This is what Thomas Andresen is looking to change.

Continue reading “Biological nano-drones can vaccinate against cancer” »

Boosting the transport of mitochondria (cell energy suppliers) along neuronal axons enhances the ability of mouse nerve cells to repair themselves and regrow after injury or disease, researchers at the National Institute of Neurological Disorders and Stroke report in The Journal of Cell Biology.

Neurons need large amounts of energy to extend their axons long distances through the body. This energy — in the form of adenosine triphosphate (ATP) — is provided by mitochondria.

Continue reading “Mobilizing mitochondria to regenerate damaged neurons” »

A meta-analysis of 45 studies (64 publications) of consumption of whole grain by an international team of researchers, led by Dagfinn Aune, PhD, at Imperial College London, found lower risks of coronary heart disease and cardiovascular disease overall, as well as deaths from all causes and from specific diseases, including stroke, cancer, diabetes, infectious and respiratory diseases.

The researchers say these results “strongly support dietary recommendations to increase intake of whole grain foods in the general population to reduce risk of chronic diseases and premature mortality.”

Continue reading “Higher intake of whole grains associated with lower risk of major chronic diseases and death” »

Provided the variants for intelligence can be figured out and the genetic editing tools sufficiently refined (no small matter, in either case), Hsu thinks there’s an incredible potential for improvement. He’s written for the science magazine Nautilus that his calculations from the work at BGI indicate a potential for “very roughly, about 100 standard deviations of improvement, corresponding to an IQ of over 1,000.”

That’s a level of intelligence beyond what we can comprehend right now.

At the same time, we’re not just working on improving biological intelligence. We’re also working on artificial intelligence and machine learning. Smarter humans might be better able to solve those problems, helping us create smarter machines. Smart machines capable of processing big data are already essential for efforts to understand millions of human genomes. These things work together.

Continue reading “We’re about to become more intelligent than at any other point in human history” »

Economists, investors and medical insurers can’t figure out how to pay for cutting-edge drugs.

By Erika Check Hayden, Nature magazine on June 15, 2016.

Excellent article on iPS. Imagine many of us in our lives have designed or researched and develop new technologies or solutions to solve a specific set of problems or to address a specific set of opportunities; and ended up to our surprise to take in a different direction. This is one of those stories.

Induced pluripotent stem cells were supposed to herald a medical revolution. But ten years after their discovery, they are transforming biological research instead.

List of the who’s who are leading some of key bio programs around nextgen bio/ living cell technologies.

According to GEN’s experts, synthetic biology isn’t yet plug-and-play, but cellular processes are being engineered into biosensing systems as well as biologics production. Soon, for tasks from theranostics to regenerative medicine, “there will be a synbio app for that.”

The new goal is to reverse aging, not only in animals, but in humans. And age reversal is essential, as significant age-related disruption has already occurred in most people due to changes in our gene expression profiles.

Gene expression patterns change with age. This influences the rate at which an individual ages, and also determines what senile disorders they are likely to contract. But innovative gene-editing methods based on a unique technology called CRISPR (clustered regularly interspaced short palindromic repeats) are now being successfully harnessed for use as an age-reversal therapy for humans.

In response to these breakthroughs, Life Extension® magazine sent biogerontologist Dr. Gregory M. Fahy to Harvard University to interview Dr. George Church, who is a leading developer of cutting-edge CRISPR techniques. Here, Dr. Church explains remarkable opportunities for transforming human aging that may begin to unfold sooner than most have imagined.

Continue reading “First phase 1 human aging reversal trials (GDF, Myostatin) in a year or two and George Church discusses how to affordably rejuvenate the whole body” »