Lifeboat Foundation

Why our metabolism slows down as we age and the diseases it contributes to.

Researchers discover reasons for our age-related metabolic slowdown and show that metabolic changes lead to disease and aging.

If scientists could precisely regulate gene expression, they could turn off the genes responsible for illness and disease and turn on those that enhance health and the immune system.

“This is why controlling gene expression is so fundamental,” said Northwestern University’s Julius Lucks. “Once you get a good handle on it, you can do anything.”

For Lucks, having a “good” handle on gene expression might be an understatement. He and his team have developed a powerful and versatile tool that achieves gene activation thousands of times better than nature.

A new PBS film educates viewers about gene therapy at a time when the once controversial field of research is starting to bear fruit.

The benefits of rejuvenation biotechnology to end age-related diseases could go beyond just the individual.

As I wrote in a different article, rejuvenation biotechnology promises a range of benefits for individuals. Lest anyone thinks that’s all rejuvenation has to offer, I reckon it’s worth discussing other ways that this technology would benefit larger groups of people—namely, your friends and family. If you are rejuvenated, that’s all good for you, but is there anything good coming out of it for your dear ones? Oh, yes.

Two burdens relieved with a single shot

Continue reading “Why Eradicating Age-related Disease Could Benefit You and Your Family” »

Izpisúa, Blasco, De Grey, and Magalhães meet in Madrid at the end of summer at the first “International Longevity and Cryopreservation Summit.” The conference lasts two days and is held in the CSIC, attracting prominent scientists, futurists and freaks, as conference organizer and Vidaplus President Txetxu Mazuelas, refers to them. The scientific world and the futuristic world inevitably clash. One of the most heated debates is on the cryopreservation of human beings – a kind of plan B that puts humans on ice while they work out the secret to eternal life.

Could we live to 140? 1,000? Is there a limit? Scientific research into extending the human lifespan is being backed by Silicon Valley giants such as Google and Facebook.

Lyme disease is exceedingly difficult to treat, due to its well-known shape-shifting (pleomorphic) abilities, with conventional antibiotics often failing to produce a long-term cure. Could the commonly used natural plant Stevia provide a safer, and more effective means to combat this increasingly prevalent infection?

A promising new preclinical study has revealed that whole stevia leaf extract possesses exceptional antibiotic activity against the exceedingly difficult to treat pathogen Borrelia Burgdorferi known to cause Lyme disease. The study found.

Genome editing technologies have revolutionized biomedical science, providing a fast and easy way to modify genes. However, the technique allowing scientists to carryout the most precise edits, doesn’t work in cells that are no longer dividing — which includes most neurons in the brain. This technology had limited use in brain research, until now. Research Fellow Jun Nishiyama, M.D., Ph.D., Research Scientist, Takayasu Mikuni, M.D., Ph.D., and Scientific Director, Ryohei Yasuda, Ph.D. at the Max Planck Florida Institute for Neuroscience (MPFI) have developed a new tool that, for the first time, allows precise genome editing in mature neurons, opening up vast new possibilities in neuroscience research.

This novel and powerful tool utilizes the newly discovered gene editing technology of CRISPR-Cas9, a viral defense mechanism originally found in bacteria. When placed inside a cell such as a neuron, the CRISPR-Cas9 system acts to damage DNA in a specifically targeted place. The cell then subsequently repairs this damage using predominantly two opposing methods; one being non-homologous end joining (NHEJ), which tends to be error prone, and homology directed repair (HDR), which is very precise and capable of undergoing specified gene insertions. HDR is the more desired method, allowing researchers flexibility to add, modify, or delete genes depending on the intended purpose.

Coaxing cells in the brain to preferentially make use of the HDR DNA repair mechanism has been rather challenging. HDR was originally thought to only be available as a repair route for actively proliferating cells in the body. When precursor brain cells mature into neurons, they are referred to as post-mitotic or nondividing cells, making the mature brain largely inaccessible to HDR — or so researchers previously thought. The team has now shown that it is possible for post-mitotic neurons of the brain to actively undergo HDR, terming the strategy “vSLENDR (viral mediated single-cell labeling of endogenous proteins by CRISPR-Cas9-mediated homology-directed repair).” The critical key to the success of this process is the combined use of CRISPR-Cas9 and a virus.

Researchers have developed a technique that enables gene editing on neurons — something previously thought to be impossible. This new tool will present amazing new opportunities for neuroscience research.

Technologies designed for editing the human genome are transforming biomedical science and providing us with relatively simple ways to modify and edit genes. However, precision editing has not been possible for cells that have stopped dividing, including mature neurons. This has meant that gene editing has been of limited use in neurological research — until now. Researchers at the Max Planck Florida Institute for Neuroscience (MPFI) have created a new tool that allows, for the first time ever, precise genome editing in mature neurons. This relieves previous constraints and presents amazing new opportunities for neuroscience research.

Speaking of concerns, I’m a bit concerned that the discussion about what might go wrong or how to prevent this or that hypothetical problem might draw attention away from another, possibly even more important question: Why do we strive to make rejuvenation a reality? There’s not much point in doing something if it doesn’t yield any benefits, especially if that something requires as much hard work as this cause does; so, what are the expected benefits of rejuvenation?

The benefits are many; some are obvious, and some are less so. The ones I’ll discuss in this article are the ones I see as obvious—tangible, immediate benefits for the people undergoing rejuvenation.