Lifeboat Foundation

Just like how letters are strung together to form words, our DNA is also strung together by letters to encode proteins. The genetic alphabet contains only 4 natural letters — A, C, G and T, which hold the blueprint for the production of proteins that make our bodies work. Now, researchers from the Institute of Bioengineering and Nanotechnology (IBN) of the Agency for Science, Technology and Research (A*STAR) have created a DNA technology with two new genetic letters that could better detect infectious diseases, such as dengue and Zika.

Genetic alphabet expansion technology is the introduction of artificial base pairs into DNA. The existing four genetic letters are naturally bound together in base pairs of A-T and G-C. These specific base pair formations are essential in DNA replication, which occurs in all living organisms. It is the process by which a DNA molecule is duplicated to produce two identical molecules.

“The expansion of the genetic alphabet is a significant scientific achievement. It sheds insights into DNA’s natural replication mechanism, which will help us to design unique DNA molecules and technologies. For example, our technology can be used to create novel diagnostics and therapeutic agents with superior efficacy,” said IBN Executive Director Professor Jackie Ying.

There are multiple software options that analyze your genetic data and make recommendations on which supplements you should be taking.

Defeating age-related diseases may create challenges for society, but is that worse than not doing anything?

In these six years, I’ve spent as a rejuvenation advocate, I’ve had to deal with the traditional objections raised against the idea of longer lifespans. These objections touch a variety of different topics, but they aren’t terribly many: we’re talking about maybe a dozen of them, and these days, I hardly ever hear an objection I haven’t discussed before.

However few or many, and deserving of specific answers, these objections may be, they can all be reduced down to a single, general form: “Rejuvenation biotechnologies would cause [insert problem here], so it’s best not to go there.” And just like there are specific answers for each specific objection, there are general answers for their general form—Aubrey de Grey’s famous “two more general answers”.

Continue reading “Rejuvenation May Bring Challenges to Society but are they Worse than Age-related Diseases?” »

Scientists are altering a powerful gene-editing technology in hopes of one day fighting diseases without making permanent changes to people’s DNA.

The trick: Edit RNA instead, the messenger that carries a gene’s instructions.

“If you edit RNA, you can have a reversible therapy,” important in case of side effects, said Feng Zhang of the Broad Institute of MIT and Harvard, a gene-editing pioneer whose team reported the new twist Wednesday in the journal Science.

One of the most defining scientific discoveries in recent decades is the development of induced pluripotent stem cells, which lets scientists revert adult cells back into an embryonic-like blank state and then manipulating them to become a particular kind of tissue.

But now a new model could do away with this time-consuming process, taking out the middle step and directly programming cells to become whatever we want them to be.

“Cells in our body always self-specialise,” explains bioinformatics researcher Indika Rajapakse from the University of Michigan.

Continue reading “New Algorithm Could Let Us Reprogram Any Cell Into Any Other Cell Type” »

The first results of two human clinical trials using stem cell therapy for age-related frailty have been published, and the results are very impressive indeed. The studies show that the approach used is effective in tackling multiple key age-related factors.

Aging research has made significant progress in the last few years, with senescent cell clearing therapies entering human trials this year, DNA repair in human trials, and a number of other exciting therapies nearing human testing. We are reaching the point where therapies that target aging processes are no longer a matter of speculation; they are now an undeniable matter of fact.

Toyota envisions smart cars and wearables saving lives in car crashes by working to predict heart attacks or diabetic blackouts among drivers.

A new vaccine targeting dozens of new strains of pneumonia could potentially save “hundreds of thousands of lives” according to researchers. Early studies show the new vaccine effectively protects against a variety of bacteria that causes pneumococcal disease including pneumonia, meningitis and sepsis.

Since the introduction in the early 2000s of vaccines targeting the most deadly forms of pneumonia, the World Health Organization has estimated global deaths of children from the disease have been cut in half. Alongside better nutrition and access to antibiotics, a vaccine against the 23 most deadly pneumonia-causing bacteria has been held as responsible for the millions of lives saved.

Now a team of scientists from the University at Buffalo and New York University’s Langone Medical Center has developed a new vaccine that targets another 50 strains of a bacterium called Streptococcus pneumoniae, the primary bacteria responsible for pneumococcal disease.

Over the past few years, there has been a tradition of longevity researchers and activists around the world to organize events on or around October 1 — the UN International Day of Older Persons, or Longevity Day. In recent years this has been extended to include the entire month of November as a Longevity Month where activists organize various activities and events to raise awareness for aging research.

This year we have continued this tradition with the Longevity Month “I am the Lifespan” event, where people tell us their story and how they got interested in aging research and doing something about age-related diseases. and it has been a great success so far. Lots of people have sent in their stories and we have been publishing them on our Facebook page the last few weeks. We wanted to share some of these stories with you and a little about the people behind them.