Lifeboat Foundation

The human microbiome, the huge collection of microbes that live inside and on our body, profoundly affects human health and disease. The human gut flora in particular, which harbor the densest number of microbes, not only break down nutrients and release molecules important for our survival but are also key players in the development of many diseases including infections, inflammatory bowel diseases, cancer, metabolic diseases, autoimmune diseases, and neuropsychiatric disorders.

Most of what we know about human–microbiome interactions is based on correlational studies between disease state and bacterial DNA contained in stool samples using genomic or metagenomic analysis. This is because studying direct interactions between the microbiome and intestinal tissue outside the human body represents a formidable challenge, in large part because even commensal bacteria tend to overgrow and kill human cells within a day when grown on culture dishes. Many of the commensal microbes in the intestine are also anaerobic, and so they require very low oxygen conditions to grow which can injure human cells.

A research team at Harvard’s Wyss Institute for Biologically Inspired Engineering led by the Institute’s Founding Director Donald Ingber has developed a solution to this problem using ‘organ-on-a-chip’ (Organ Chip) microfluidic culture technology. His team is now able to culture a stable complex human microbiome in direct contact with a vascularized human intestinal epithelium for at least 5 days in a human Intestine Chip in which an oxygen gradient is established that provides high levels to the endothelium and epithelium while maintaining hypoxic conditions in the intestinal lumen inhabited by the commensal bacteria. Their “anaerobic Intestine Chip” stably maintained a microbial diversity similar to that in human feces over days and a protective physiological barrier that was formed by human intestinal tissue. The study is published in Nature Biomedical Engineering.

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The zoonotic disease, known as “canine Brucellosis,” is spread through reproductive fluids. Instances were found at a small-dog breeding facility.

Scientists have modified the genes of viruses to nearly wipe out a drug-resistant bacteria.

Results from a recent study suggest that a revolutionary treatment may have the potential to slow, stop, or even reverse the progression of Parkinson disease.

Results from a February study of a revolutionary treatment suggest that it may be possible to slow, stop, or even reverse the progression of Parkinson disease, according to findings in the Journal of Parkinson’s Disease.

The 3-part, experimental study investigated whether using a novel delivery system to increase levels of glial cell line-derived neurotrophic factor (GDNF) can regenerate dying dopamine brain cells in patients with Parkinson disease and even reverse their condition. GDNF is a naturally occurring protein that promotes the survival of many types of neurons.

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Evidence that humans can genetically adapt to diving has been identified for the first time in a new study. The evidence suggests that the Bajau, a people group indigenous to parts of Indonesia, have genetically enlarged spleens which enable them to free dive to depths of up to 70m.

It has previously been hypothesised that the spleen plays an important role in enabling humans to free dive for prolonged periods but the relationship between spleen size and dive capacity has never before been examined in humans at the genetic level.

The findings, which are being published in the research journal Cell, could also have medical implications in relation to the condition known as Acute Hypoxia, which can cause complications in emergency medical care.

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The concept of fate is often used in the context of love and choosing a partner. In your book, you talk about a study that give a scientific explanation for the idea that “opposites attract”. A panel of men was asked to wear a T-shirt for several nights and days and they weren’t allowed to wear deodorant or eat anything too smelly. The T-shirts were presented to an array of women who were asked to sniff then and rate them in terms of attractiveness based purely on smell. It turns out that the females rated the males as more attractive if their MHC [major histocompatibility complex] systems were different from their own, because then their offspring would have a stronger immune system, a better range of armoury against potential infections. So women were kind of sniffing out Mr Right.

What else does neuroscience tell us about a successful relationship? If you image the brains of the couples who have been together for a long, long time and ask them to think about their partner, their brain will react in the same way as a drug addict’s. You can almost say this couple are addicted to each other.

You say “affection is a neurochemical event” – that’s not very romantic. Valentine’s Day with me is a lot of fun!

Continue reading “Neuroscientist Dr Hannah Critchlow: ‘Changing the way that you think is cognitively costly’” »

This amazing microchip can heal any part of your body with a single touch.

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Unity Biotech’s drug to treat an intractable arthritic condition is in late-stage human trials.

Scientist Michael Snyder tracked his own basic measurements for years. Now he’s released a study of over 100 people using similar data to make lifesaving discoveries about heart disease, cancer, and diabetes.