Lifeboat Foundation

Longevity companies have often risen and fallen with little ado. But if these financial experts are correct that biotech companies are poised to start “bringing unprecedented increases to the quality and length of human lifespans,” per CNBC, then we may start seeing serious results out of the industry.

“New Frontier”

Bank of America’s predictions would mean a six-fold increase in the amount of money in longevity companies. In a report to clients reviewed by CNBC, analysts wrote that the human lifespan may soon extend to 100 years.

Continue reading “Major Bank: The Immortality Industry Is the Next Hot Investment” »

Feeding mosquitoes sugar makes them less attracted to humans, a response that is regulated by the protein vitellogenin, according to a study publishing May 9 in the open-access journal PLOS Biology by Jessica Dittmer, Paolo Gabrieli and colleagues at the Università degli Studi di Pavia in Italy.

Female mosquitoes must feed on blood to provide energy and nutrients for their developing eggs, but they can also supplement their diet with sugars by drinking plant nectar or sap. The team fed young female tiger mosquitos (Aedes albopictus) sugar solutions, and found it reduced their attraction to human skin. Female energy levels constantly increase after feeding sugars, and they are not related to the insects’ motivation to find a host.

Transcriptome sequencing revealed a wave of gene expression changes associated with this reduction in host-seeking behaviour, which affected at least 23 genes including the vitellogenin gene Vg-2—known to play a role in ovary development. RNA interference experiments to knockdown the Vg-2 gene expression restored the mosquitos’ attraction to humans, confirming the gene’s key role in regulating feeding behaviour.

Continue reading “Egg yolk precursor protein regulates mosquitoes’ attraction to humans” »

A new open-access study from researchers at the Biomedical Research Centre in the United Kingdom shows how two antibiotics and Vitamin C can be combined to suppress cancer stem cells (CSCs) of the breast [1].

While antibiotics are not normally effective against cancer, and Vitamin C is more well-known for its role in supporting the immune system, this combination has been shown to attack cancer stem cells through a combination of mitochondrial suppression and oxidative attacks on the mitochondria, thus causing mitochondrial growth to falter.

Olive trees don’t just dot the landscape in Puglia, Italy; they define it. They are so important here, in the heel of Italy’s boot, that locals use words like “patrimony” and “cultural heritage” when describing them. But what is worrying olive growers here is a disease that’s killing olive trees by the millions.

Paul Cappelli, who’d been an advertising executive in New York City until a few years ago, left his job and moved to a home on the ancient Appian Way surrounded by olive trees, and entered the oil business. “Not the Texas oil business; I’m in the real oil business!” he said.

Today, Villa Cappelli produces about 10,000 liters of olive oil, 95 percent of it sold in the U.S.

Continue reading “A pathogen is destroying Italy’s olive trees” »

Longevity technology number one, according to the Longevity Impact Forum rating, proven by Patient zero.

Liz Parrish, CEO of BioViva USAa short clip from her gene therapy that she took in 2015 against biological aging. This is the first step to curing diseases like Alzheimer’s disease, heart disease, kidney failure and cancer. If we work toward this goal quickly we could save almost 8 billion people from inhumane and expensive deaths.
https://www.BioViva-Science.com
https://www.Integrated-Health-Systems.com

Continue reading “BioViva -- First Gene Therapy To Treat Biological Aging -- Patient Zero — Liz Parrish” »

In his 1971 State of the Union address, president Richard Nixon promised to kick off what would soon come to be known as the War on Cancer, asking congress for a $100 million appropriation to launch a campaign for finding a cure. “The time has come in America when the same kind of concentrated effort that split the atom and took man to the moon should be turned toward conquering this dread disease,” he said. “Let us make a total national commitment to achieve this goal.”

Welcome to the War on Aging, where death is optional.

We characterize a novel probe binding-site polymorphism detectable solely by melt curve analysis using the Roche LightCycler HSV 1/2 analyte-specific reagent real-time PCR assay. The frequencies of this novel (47°C) and previously described intermediate (60 to 62°C) melt curves were 0.016% and 4.9%, respectively.

The clinical spectrum of herpes simplex virus (HSV-1, HSV-2) infection ranges from subclinical mucosal shedding to vesicular or ulcerative lesions of skin and mucous membranes, hepatitis, keratitis, pneumonitis, sepsis, and meningoencephalitis. For laboratory diagnosis, laborious cell culture techniques have been largely supplanted with real-time PCR (qPCR) due to marked improvements in test sensitivity and turnaround time. Various laboratory-developed and commercially available qPCR products (analyte-specific reagents [ASR]; FDA approved) exist. In the United States, the LightCycler HSV 1/2 ASR real-time PCR assay (HSV qPCR; Roche Diagnostics, Indianapolis, IN) is commonplace, being used by about 30% of clinical laboratories according to a recent College of American Pathologists (CAP) participant summary.

Physicians making life-and-death decisions about organ transplants, cancer treatments or heart surgeries typically don’t give much thought to how artificial intelligence might help them. And that’s how researchers at Carnegie Mellon University say clinical AI tools should be designed—so doctors don’t need to think about them.

A surgeon might never feel the need to ask an AI for advice, much less allow it to make a clinical decision for them, said John Zimmerman, the Tang Family Professor of Artificial Intelligence and Human-Computer Interaction in CMU’s Human-Computer Interaction Institute (HCII). But an AI might guide decisions if it were embedded in the decision-making routines already used by the clinical team, providing AI-generated predictions and evaluations as part of the overall mix of information.

Zimmerman and his colleagues call this approach “Unremarkable AI.”

Continue reading “Researchers make transformational AI seem ‘unremarkable’” »

Biomedical application of quercetin (QT) as an effective flavonoid has limitations due to its low bioavailability. Superparamagnetic iron oxide nanoparticle (SPION) is a novel drug delivery system that enhances the bioavailability of quercetin. The effect of short time usage of quercetin on learning and memory function and its signaling pathways in the healthy rat is not well understood. The aim of this study was to investigate the effect of free quercetin and in conjugation with SPION on learning and memory in healthy rats and to find quercetin target proteins involved in learning and memory using Morris water maze (MWM) and computational methods respectively. Results of MWM show an improvement in learning and memory of rats treated with either quercetin or QT-SPION. Better learning and memory functions using QT-SPION reveal increased bioavailability of quercetin. Comparative molecular docking studies show the better binding affinity of quercetin to RSK2, MSK1, CytC, Cdc42, Apaf1, FADD, CRK proteins. Quercetin in comparison to specific inhibitors of each protein also demonstrates a better QT binding affinity. This suggests that quercetin binds to proteins leading to prevent neural cell apoptosis and improves learning and memory. Therefore, SPIONs could increase the bioavailability of quercetin and by this way improve learning and memory.